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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and early detection remains a major clinical challenge due to the absence of specific symptoms and reliable biomarkers. In this work, we propose a new multimodal…

Symbolic regression is a machine learning technique, and it has seen many advancements in recent years, especially in genetic programming approaches (GPSR). Furthermore, it has been known for many years that constant optimization of…

Machine Learning · Computer Science 2024-12-04 L. G. A dos Reis , V. L. P. S. Caminha , T. J. P. Penna

Motivation: Proteomic mass spectrometry analysis is becoming routine in clinical diagnostics, for example to monitor cancer biomarkers using blood samples. However, differential proteomics and identification of peaks relevant for class…

Genomics · Quantitative Biology 2015-10-06 Sebastian Gibb , Korbinian Strimmer

Selective labels occur when label observations are subject to a decision-making process; e.g., diagnoses that depend on the administration of laboratory tests. We study a clinically-inspired selective label problem called disparate…

Machine Learning · Computer Science 2024-06-28 Trenton Chang , Jenna Wiens

Advances in methods of biological data collection are driving the rapid growth of comprehensive datasets across clinical and research settings. These datasets provide the opportunity to monitor biological systems in greater depth and at…

Molecular Networks · Quantitative Biology 2025-01-20 Joshua Pickard , Cooper Stansbury , Amit Surana , Lindsey Muir , Anthony Bloch , Indika Rajapakse

miRNA and gene expression profiles have been proved useful for classifying cancer samples. Efficient classifiers have been recently sought and developed. A number of attempts to classify cancer samples using miRNA/gene expression profiles…

Computational Engineering, Finance, and Science · Computer Science 2014-01-21 Rania Ibrahim , Noha A. Yousri , Mohamed A. Ismail , Nagwa M. El-Makky

Researchers in the behavioral and social sciences use linear discriminant analysis (LDA) for predictions of group membership (classification) and for identifying the variables most relevant to group separation among a set of continuous…

Methodology · Statistics 2025-05-28 Ricarda Graf , Marina Zeldovich , Sarah Friedrich

For a medical diagnosis, health professionals use different kinds of pathological ways to make a decision for medical reports in terms of patients medical condition. In the modern era, because of the advantage of computers and technologies,…

Machine Learning · Statistics 2021-06-08 Fahad B. Mostafa , Md Easin Hasan

Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically consider a limited number of hypotheses, most of which are…

Genomics · Quantitative Biology 2007-05-23 Zhong Li , Aris Floratos , David Wang , Andrea Califano

Detecting interaction effects (IEs) in meta-regression is challenging, especially when few studies are available and many plausible interactions are considered. In many meta-analyses, interpretability is essential, which limits the use of…

Other Statistics · Statistics 2026-03-09 Jan-Bernd Igelmann , Paula Lorenz , Markus Pauly

Automatic analysis of bioacoustic signals is a fundamental tool to evaluate the vitality of our planet. Frogs and bees, for instance, may act like biological sensors providing information about environmental changes. This task is…

Quantitative Methods · Quantitative Biology 2021-03-19 Bernardo B. Gatto , Juan G. Colonna , Eulanda M. dos Santos , Alessandro L. Koerich , Kazuhiro Fukui

Identification of taxa can significantly be assisted by statistical classification based on trait measurements in two major ways; either individually or by phylogenetic (clustering) methods. In this paper we present a general Bayesian…

Applications · Statistics 2021-09-17 Måns Karlsson , Ola Hössjer

Our aim in this paper is to analyse the phenotypic effects (evolvability) of diverse coding conversion operators in an instance of the states based evolutionary algorithm (SEA). Since the representation of solutions or the selection of the…

Neural and Evolutionary Computing · Computer Science 2009-05-19 Maroun Bercachi , Philippe Collard , Manuel Clergue , Sebastien Verel

Machine learning--based anomaly detection (AD) methods are promising tools for extending the coverage of searches for physics beyond the Standard Model (BSM). One class of AD methods that has received significant attention is resonant…

Accurate and efficient cell detection is crucial in many biomedical image analysis tasks. We evaluate the performance of several Deep Learning (DL) methods for cell detection in Papanicolaou-stained cytological Whole Slide Images (WSIs),…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Marco Acerbis , Nataša Sladoje , Joakim Lindblad

Two-dimensional (2D) Multiple Signal Classification algorithm is a powerful technique for high-resolution direction-of-arrival (DOA) estimation in array signal processing. However, the exhaustive search over the 2D an-gular domain leads to…

Signal Processing · Electrical Eng. & Systems 2025-07-29 Bo Zhou , Kaijie Xu , Yinghui Quan , Mengdao Xing

Breast cancer is not preventable because of its unknown causes. However, its early diagnosis increases patients' recovery chances. Machine learning (ML) can be utilized to improve treatment outcomes in healthcare operations while…

Machine Learning · Computer Science 2024-08-09 Kamyab Karimi , Ali Ghodratnama , Reza Tavakkoli-Moghaddam

Genome-wide association studies have become increasingly common due to advances in technology and have permitted the identification of differences in single nucleotide polymorphism (SNP) alleles that are associated with diseases. However,…

Quantitative Methods · Quantitative Biology 2015-09-24 Rosemary Braun , Kenneth Buetow

Principal Component Analysis (PCA) has been used to study the pathogenesis of diseases. To enhance the interpretability of classical PCA, various improved PCA methods have been proposed to date. Among these, a typical method is the…

Machine Learning · Computer Science 2019-05-29 Chun-Mei Feng , Yong Xu , Jin-Xing Liu , Ying-Lian Gao , Chun-Hou Zheng

The ability to quickly and accurately identify microbial species in a sample, known as metagenomic profiling, is critical across various fields, from healthcare to environmental science. This paper introduces a novel method to profile…

Genomics · Quantitative Biology 2025-04-10 Riselda Kodra , Hadjer Benmeziane , Irem Boybat , William Andrew Simon