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Quantitative susceptibility mapping (QSM) is a powerful MRI technique that has shown great potential in quantifying tissue susceptibility in numerous neurological disorders. However, the intrinsic ill-posed dipole inversion problem greatly…

Image and Video Processing · Electrical Eng. & Systems 2019-10-31 Yicheng Chen , Angela Jakary , Sivakami Avadiappan , Christopher P. Hess , Janine M. Lupo

Quantitative susceptibility mapping (QSM) has been increasingly applied in longitudinal studies of neurodegenerative diseases and aging to assess temporal alterations in brain iron and myelin. The accuracy of such investigations depends on…

Quantitative Methods · Quantitative Biology 2026-05-05 Jiye Kim , Hwihun Jeong , Taechang Kim , Eunseon Jeong , Jinhee Jang , Yangsean Choi , Jongho Lee

Recently, deep neural network-powered quantitative susceptibility mapping (QSM), QSMnet, successfully performed ill conditioned dipole inversion in QSM and generated high-quality susceptibility maps. In this paper, the network, which was…

Image and Video Processing · Electrical Eng. & Systems 2019-10-15 Woojin Jung , Jaeyeon Yoon , Joon Yul Choi , Jae Myung Kim , Yoonho Nam , Eung Yeop Kim , Jongho Lee

Quantitative susceptibility mapping (QSM) has demonstrated great potential in quantifying tissue susceptibility in various brain diseases. However, the intrinsic ill-posed inverse problem relating the tissue phase to the underlying…

Computer Vision and Pattern Recognition · Computer Science 2021-05-21 Ruimin Feng , Jiayi Zhao , He Wang , Baofeng Yang , Jie Feng , Yuting Shi , Ming Zhang , Chunlei Liu , Yuyao Zhang , Jie Zhuang , Hongjiang Wei

Purpose: Quantitative Susceptibility Mapping (QSM) reconstruction is a challenging inverse problem driven by poor conditioning of the field to susceptibility transformation. State-of-art QSM reconstruction methods either suffer from image…

Medical Physics · Physics 2019-03-14 Juan Liu , Andrew S. Nencka , L. Tugan Muftuler , Brad Swearingen , Robin Karr , Kevin M. Koch

Motivation - The test-retest reliability of quantitative susceptibility mapping (QSM) is affected by parameters of the acquisition protocol such as the angulation of acquisition plane with respect to the B0 field direction and spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-11-26 Shuai Huang , Thomas Denney , Deqiang Qiu

Quantitative susceptibility mapping (QSM) is a MRI technique that estimates tissue magnetic susceptibility. The generation of QSM requires solving a challenging ill-posed field-to-source inversion problem. Recently, several deep learning…

Medical Physics · Physics 2022-06-28 Juan Liu , Kevin Koch

Quantitative susceptibility mapping (QSM) provides a valuable tool for quantifying susceptibility distributions in human brains; however, two types of opposing susceptibility sources (i.e., paramagnetic and diamagnetic), may coexist in a…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Min Li , Chen Chen , Zhenghao Li , Yin Liu , Shanshan Shan , Peng Wu , Pengfei Rong , Feng Liu , G. Bruce Pike , Alan H. Wilman , Hongfu Sun , Yang Gao

Quantitative Susceptibility Mapping (QSM) quantifies tissue magnetic susceptibility from magnetic-resonance phase data and plays a crucial role in brain microstructure imaging, iron-deposition assessment, and neurological-disease research.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-11 Xuan Cai , Ruo-Mi Guo , Xiao-Wen Luo , Jing Zhao , Silun Wang , Tao Tan , Yue Liu , Hongbin Han , Mengting Liu

Abnormal iron accumulation in the brain subcortical nuclei has been reported to be correlated to various neurodegenerative diseases, which can be measured through the magnetic susceptibility from the quantitative susceptibility mapping…

Image and Video Processing · Electrical Eng. & Systems 2020-08-04 Chao Chai , Pengchong Qiao , Bin Zhao , Huiying Wang , Guohua Liu , Hong Wu , E Mark Haacke , Wen Shen , Chen Cao , Xinchen Ye , Zhiyang Liu , Shuang Xia

Quantitative Susceptibility Mapping (QSM) dipole inversion is an ill-posed inverse problem for quantifying magnetic susceptibility distributions from MRI tissue phases. While supervised deep learning methods have shown success in specific…

Image and Video Processing · Electrical Eng. & Systems 2024-03-22 Zhuang Xiong , Wei Jiang , Yang Gao , Feng Liu , Hongfu Sun

Quantitative susceptibility mapping (QSM) is a post-processing technique for deriving tissue magnetic susceptibility distribution from MRI phase measurements. Deep learning (DL) algorithms hold great potential for solving the ill-posed QSM…

Image and Video Processing · Electrical Eng. & Systems 2024-03-27 Yang Gao , Zhuang Xiong , Shanshan Shan , Yin Liu , Pengfei Rong , Min Li , Alan H Wilman , G. Bruce Pike , Feng Liu , Hongfu Sun

Recently, deep learning methods have been proposed for quantitative susceptibility mapping (QSM) data processing: background field removal, field-to-source inversion, and single-step QSM reconstruction. However, the conventional padding…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Juan Liu

Purpose: Field-to-susceptibility inversion in quantitative susceptibility mapping (QSM) is ill-posed and needs numerical stabilization through either regularization or oversampling by acquiring data at three or more object orientations.…

Quantitative susceptibility mapping (QSM) inevitably suffers from streaking artifacts caused by zeros on the conical surface of the dipole kernel in k-space. This work proposes a novel and accurate QSM reconstruction method based on a…

Computer Vision and Pattern Recognition · Computer Science 2019-10-16 Hyun-Seo Ahn , Sung-Hong Park , Jong Chul Ye

The starting point in quantitative susceptibility mapping (QSM) is a theoretical model that is used to map susceptibility distributions from magnetic field measurements. It requires regularisation techniques to avoid artefacts in the…

Mathematical Physics · Physics 2021-09-07 Rob F. Remis , Peter M. van den Berg

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. Despite significant advances in fast multiplexed imaging sensors and deep-learning-based inverse…

Purpose: For quantitative susceptibility mapping (QSM), the lack of ground-truth in clinical settings makes it challenging to determine suitable parameters for the dipole inversion. We propose a probabilistic Bayesian approach for QSM with…

Image and Video Processing · Electrical Eng. & Systems 2023-06-01 Shuai Huang , James J. Lah , Jason W. Allen , Deqiang Qiu

Phase unwrapping is a classical ill-posed problem which aims to recover the true phase from wrapped phase. In this paper, we introduce a novel Convolutional Neural Network (CNN) that incorporates a Spatial Quad-Directional Long Short Term…

Machine Learning · Computer Science 2020-10-27 Malsha V. Perera , Ashwin De Silva

The data-driven approach of supervised learning methods has limited applicability in solving dipole inversion in Quantitative Susceptibility Mapping (QSM) with varying scan parameters across different objects. To address this generalization…

Image and Video Processing · Electrical Eng. & Systems 2023-08-21 Zhuang Xiong , Yang Gao , Yin Liu , Amir Fazlollahi , Peter Nestor , Feng Liu , Hongfu Sun