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The immune system is a real-time example of an evolving system that navigates the essentially infinite complexity of protein sequence space. How this system responds to disease and vaccination is discussed. Of particular focus is the case…

Cell Behavior · Quantitative Biology 2007-05-23 Michael W. Deem

CRISPR-Cas systems are an adaptive immunity that protects prokaryotes against foreign genetic elements. Genetic templates acquired during past infection events enable DNA-interacting enzymes to recognize foreign DNA for destruction. Due to…

Genomics · Quantitative Biology 2022-02-16 Hyunjin Shim

This study explores the emergence of counter-inferential behavior in natural and artificial cognitive systems, that is, patterns in which agents misattribute empirical success or suppress adaptation, leading to epistemic rigidity or…

Artificial Intelligence · Computer Science 2025-06-10 Serge Dolgikh

Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor…

Cell Behavior · Quantitative Biology 2013-05-17 Kathleen P. Wilkie , Philip Hahnfeldt

Biological antifreezes protect cold-water organisms from freezing. An example are the antifreeze proteins (AFPs) that attach to the surface of ice crystals and arrest growth. The mechanism for growth arrest has not been heretofore…

Materials Science · Physics 2009-11-10 Leonard M. Sander , Alexei V. Tkachenko

Danger requires a strong rapid response. Speedy triggers are prone to false signals. False alarms can be costly, requiring strong negative regulators to oppose the initial triggers. Strongly opposed forces can easily be perturbed, leading…

Populations and Evolution · Quantitative Biology 2023-12-27 Steven A. Frank

The interplay between the non-Hermitian skin effect and the imaginary gap of lossy lattices results in the edge burst, a boundary-induced dynamical phenomenon in which an exceptionally large portion of particle loss occurs at the edge.…

Quantum Physics · Physics 2023-12-19 Yu-Min Hu , Wen-Tan Xue , Fei Song , Zhong Wang

It has recently been shown that the non-Hermitian skin effect can be suppressed by magnetic fields. In this work, using a two-dimensional tight-binding lattice, we demonstrate that a pseudomagnetic field can also lead to the suppression of…

Mesoscale and Nanoscale Physics · Physics 2024-06-18 Hau Tian Teo , Subhaskar Mandal , Yang Long , Haoran Xue , Baile Zhang

Solid organ transplantation has by now become a common medical procedure. Owing to the introduction of new immunosuppressive drugs, the allograft loss due to acute rejection has been reduced significantly over time. Tragically, the number…

Tissues and Organs · Quantitative Biology 2024-08-22 Vladimir M. Subbotin , Michael V. Subotin

This letter describes a 40.68 MHz wireless power transfer receiver for implantable applications focused on minimizing tissue heating. The system features a novel power radiated efficiency optimization strategy and a fast-settling active…

Systems and Control · Electrical Eng. & Systems 2025-06-10 Ronald Wijermars , Yi-Han Ou-Yang , Sijun Du , Dante Gabriel Muratore

An elastic membrane that is forced to reside in a container smaller than its natural size will deform and, upon further volume reduction, eventually crumple. The crumpled state is characterized by the localization of energy in a complex…

Materials Science · Physics 2011-03-30 Paula Mellado , Shengfeng Cheng , Andres Concha

A mutation in a protein-coding gene in DNA can alter the protein structure coded by the same gene. Structurally altered proteins usually lose their functions and sometimes gain an undesirable function instead. These types of mutations and…

Quantitative Methods · Quantitative Biology 2017-08-29 Kaan Aygen , Berkay Celik , Umut Eser

The mechanisms by which organs acquire their functional structure and realize its maintenance (or homeostasis) over time are still largely unknown. In this paper, we investigate this question on adipose tissue. Adipose tissue can represent…

We consider physics behind the FLASH modality of cancer radiation treatment where extremely short treatment times are achieved with ultra high dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing…

Medical Physics · Physics 2026-03-19 Diana Shvydka , Victor Karpov , Nilendu Gupta

Neutron skin is an exotic phenomena in unstable nuclei. The various effects in nuclear reactions caused by the neutron skin and also its relation with the properties of nuclear structure are reviewed in this article. Based on numerous…

Nuclear Theory · Physics 2024-09-12 Meng-Qi Ding , De-Qing Fang , Yu-Gang Ma

Medical non-adherence increasingly is recognized as a major medical health problem. Approximately 50% of patients do not take their medications as prescribed and such poor adherence has been shown to result in complications, death, and…

Human-Computer Interaction · Computer Science 2017-08-10 Anna Iurchenko

Surface modification of polymeric biomaterials using plasma has emerged as an effective strategy to optimize the cell-material interface without compromising the structural properties of the material. This work presents a critical review of…

Plasma Physics · Physics 2025-04-08 Jairo Rondøn , Angel Gonzalez-Lizardo

Jerne's idiotypic network theory postulates that the immune response involves inter-antibody stimulation and suppression as well as matching to antigens. The theory has proved the most popular Artificial Immune System (ais) model for…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Amanda Whitbrook , Uwe Aickelin , Jonathan Garibaldi

We present linear ensembles of dangling bond chains on a hydrogen terminated Si(100) surface, patterned in the closest spaced arrangement allowed by the surface lattice. Local density of states maps over a range of voltages extending…

Mesoscale and Nanoscale Physics · Physics 2016-07-21 John A. Wood , Mohammad Rashidi , Mohammad Koleini , Jason L. Pitters , Robert A. Wolkow

New wireless mobile technology has been released every ten years, improving previous generations' facilities. Even though 5G supports many services on demand nowadays, its higher radiation increases the queries about the safety of humans…

Networking and Internet Architecture · Computer Science 2023-10-17 N. Annalakshmi , S. Umarani
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