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Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

Applied Physics · Physics 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Quantum sensing is an emerging field with the potential to outperform classical methods in both precision and spatial resolution. However, the sensitivity of the underlying quantum platform also makes the sensors highly susceptible to their…

Quantum Physics · Physics 2025-12-15 Miriam Resch , Dennis Herb , Mirko Rossini , Joachim Ankerhold , Dominik Maile

Squeezed light are optical beams with variance below the Shot Noise Level. They are a key resource for quantum technologies based on photons, they can be used to achieve better precision measurements, improve security in quantum key…

Quantum Physics · Physics 2019-04-17 Robert Cernansky , Alberto Politi

Quantum computers allow for direct simulation of the quantum interference and entanglement used in modern interferometry experiments with applications ranging from biological sensing to gravitational wave detection. Inspired by recent…

Quantum Physics · Physics 2022-09-20 Cindy Tran , Tanaporn Na Narong , Eric S. Cooper

Optical microscopy has a diffraction limited resolution of about 250 nm. Fluorescence methods (e.g. PALM, STORM, STED) beat this, but they are still limited to 10 s of nm, and the images are an indirect pointillist representation of only…

Quantum sensing is commonly described as a constrained optimization problem: maximize the information gained about an unknown quantity using a limited number of particles. Important sensors including gravitational-wave interferometers and…

Quantum Physics · Physics 2020-08-05 Morgan W. Mitchell

In order to relate nanoparticle properties to function, fast and detailed particle characterization, is needed. The ability to characterize nanoparticle samples using optical microscopy techniques has drastically improved over the past few…

All surface plasmon resonance (SPR) devices on single-mode optical fibers' (SMF) end facets, as reported up to date, are limited by severely broad and shallow resonance spectra. The consequent poor performance when they are used as…

Optics · Physics 2016-08-26 Xiaolong He , Hui Yi , Jing Long , Xin Zhou , Jie Yang , Tian Yang

Optical bio-markers have been used extensively for intracellular imaging with high spatial and temporal resolution. Extending the modality of these probes is a key driver in cell biology. In recent years, the NV centre in nanodiamond has…

Nanophotonic objects like plasmonic nanoparticles and colloidal quantum dots can complement the functionality of molecular dyes in biomedical optics. However, their operation is usually governed by spontaneous processes, which results in…

The quantum statistical fluctuations of the electromagnetic field establish a limit, known as the shot-noise limit, on the sensitivity of optical measurements performed with classical technologies. However, quantum technologies are not…

The development of next generation medicines demand more sensitive and reliable label free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of…

Applied Physics · Physics 2019-05-22 Serena Rollo , Dipti Rani , Renaud Leturcq , Wouter Olthuis , César Pascual García

One of the most important processes in the fight against current and future pandemics is the rapid diagnosis and initiation of treatment of viruses in humans. In these times, the development of high-sensitivity tests and diagnostic kits is…

Optics · Physics 2022-12-13 Junfei Wang , Zhenyu Xu , Domna G. Kotsifaki

Label-free quantitative phase imaging is a vital tool for optical microscopy and metrology applications. A hair-thin multimode fiber stands out as a very attractive platform for minimally invasive imaging. Here we propose and experimentally…

We show that a single moving quantum sensor provides complete access to spatially correlated scalar fields. We demonstrate that with either trajectory or internal state control, one can selectively measure any linear functional, e.g. a…

Quantum Physics · Physics 2025-12-19 Paul Aigner , Wolfgang Dür

The detection of quantal exocytic events from neurons and neuroendocrine cells is a challenging task in neuroscience. One of the most promising platforms for the development of a new generation of biosensors is diamond, due to its…

Instrumentation and Detectors · Physics 2016-08-30 F. Picollo , A. Battiato , E. Carbone , L. Croin , E. Enrico , J. Forneris , S. Gosso , P. Olivero , A. Pasquarelli , V. Carabelli

Silicon-based photonic biosensors, such as microring resonators and Mach-Zehnder interferometers, offer significant potential for the detection of analytes at low concentrations. To enhance response time and improve the limit of detection…

Optics · Physics 2024-07-01 Anders Henriksson , Peter Neubauer , Mario Birkholz

Accessing fluid infiltration in nanogranular coatings is an outstanding challenge, of relevance for applications ranging from nanomedicine to catalysis. A sensing platform, allowing to quantify the amount of fluid infiltrated in a…

The biomechanical properties of cells and tissues play an important role in our fundamental understanding of the structures and functions of biological systems at both the cellular and subcellular levels. Recently, Brillouin microscopy,…

We present low-temperature measurements of low-loss superconducting nanowire-embedded resonators in the low-power limit relevant for quantum circuits. The superconducting resonators are embedded with superconducting nanowires with widths…

Superconductivity · Physics 2017-08-09 Jonathan Burnett , James Sagar , Oscar W. Kennedy , Paul A. Warburton , Jonathan C. Fenton