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A nanoparticle detection scheme with single particle resolution is presented. The sensor contains only a taper fiber thus offering the advantages of compactness and installation flexibility. Sensing method is based on monitoring the…

Optics · Physics 2013-05-31 Jiangang Zhu , Sahin Kaya Ozdemir , Lan Yang

Optically addressable spin-based quantum sensors enable nanoscale measurements of temperature, magnetic field, pH, and other physical properties of a system. Advancing the sensors beyond proof-of-principle demonstrations in living cells and…

Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the…

Applied Physics · Physics 2017-08-02 Ozlem Yavas , Mikael Svedendahl , Paulina Dobosz , Vanesa Sanz , Romain Quidant

Screening of unknown particles, including viruses and nanoparticles, is key in medicine, industry and pollutant determination. However, existing techniques require sample a priori knowledge or modification (e.g. fluorescence). Here we…

Over the preceding years, nickel (Ni) and its compounds have been increasingly employed in various aspects of human social life, metallurgical/industrial manufactures, healthcare, and chemical processes. Although Ni is considered an…

Applied Physics · Physics 2025-07-08 Sudhanshu Naithani , Heena , Pooja Sharma , Samar Layek , Franck Thetiot , Tapas Goswami , Sushil Kumar

This work presents a quantum-limited optomechanical sensing platform for real-time detection and discrimination of chiral molecules, based on a multilayer hybrid plasmonic-mechanical resonator. Leveraging quantum zero-point motion and…

Optics · Physics 2025-07-29 Giuseppina Simone

We have demonstrated atomically thin, quantum capacitance-limited, field-effect transistors (FETs) that enable the detection of pH changes with ~75-fold higher sensitivity (4.4 V/pH) over the Nernst value of 59 mV/pH at room temperature…

Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the…

Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and…

Nonlinear optical microscopy techniques have emerged as a set of successful tools for biological imaging. Stimulated emission microscopy belongs to a small subset of pump-probe techniques which can image non-fluorescent samples without…

Ultrasensitive optical detection of nanometer-scaled particles is highly desirable for applications in early-stage diagnosis of human diseases, environmental monitoring, and homeland security, but remains extremely difficult due to ultralow…

Biosensing based on whispering-gallery mode (WGM) resonators has been continuously studied with great attention due to its excellent sensitivity guaranteeing the label-free detection. However, its practical impact is insignificant to date…

Applied Physics · Physics 2020-01-08 Yeseul Kim , Hansuek Lee

Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and…

The ultimate goal and the theoretical limit of weak signal detection is the ability to detect a single photon against a noisy background. [...] In this paper we show, that a combination of a quantum metamaterial (QMM)-based sensor matrix…

In this work a quantum imaging setup based on undetected squeezed photons is employed for metrological applications such as sensitive phase measurement and quantum imaging. In spite of the traditional quantum imaging with undetected…

Quantum Physics · Physics 2025-06-10 S. Samimi , Z. Ghasemi , H. Mohammadi

Single-molecule fluorescence techniques have revolutionized our ability to study proteins. However, the presence of a fluorescent label can alter the protein structure and/or modify its reaction with other species. To avoid the need for a…

Biological Physics · Physics 2022-04-07 Aleksandr Barulin , Prithu Roy , Jean-Benoît Claude , Jérôme Wenger

Small solid state qubits, most prominently single spins in solids, can be remarkable sensors for various physical quantities ranging from magnetic fields to temperature. They package the performance of their bulk semiconductor counterparts…

Quantum Physics · Physics 2019-06-12 Friedemann Reinhard

Current optical detection schemes for single molecules require light absorption, either to produce fluorescence or direct absorption signals. This severely limits the range of molecules that can be detected, because most molecules are…

Chemical Physics · Physics 2012-07-06 Peter Zijlstra , Pedro M. R. Paulo , Michel Orrit

We propose a theoretical scheme to enhance the signal-to-noise ratio in ultrasensitive detection with the help of quantum correlation. By introducing the auxiliary oscillator and treated as an added probe for weak field detection, the…

Quantum Physics · Physics 2019-06-12 Wen-Zhao Zhang , Li-Bo Chen , Jiong Cheng , Yun-Feng Jiang

Rapid detection of bacterial growth is crucial in clinical, food safety, and environmental contexts, yet conventional optical methods are limited by noise and require hours of incubation. Here, we present the first experimental…