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In this study, we present a novel molecular fingerprint generation method based on multiparameter persistent homology. This approach reveals the latent structures and relationships within molecular geometry, and detects topological features…

Biomolecules · Quantitative Biology 2023-11-21 Andac Demir , Bulent Kiziltan

Inspired by persistent homology in topological data analysis, we introduce the homological eigenvalues of the graph $p$-Laplacian $\Delta_p$, which allows us to analyse and classify non-variational eigenvalues. We show the stability of…

Spectral Theory · Mathematics 2023-11-28 Dong Zhang

Persistent Laplacians are matrix operators that track how the shape and structure of data transform across scales and are popularly adopted in biology, physics, and machine learning. Their eigenvalues are concise descriptors of geometric…

Machine Learning · Computer Science 2025-06-27 Le Vu Anh , Mehmet Dik , Nguyen Viet Anh

We develop here an algorithmic framework for constructing consistent multiscale Laplacian eigenfunctions (vectors) on data. Consequently, we address the unsupervised machine learning task of finding scalar functions capturing consistent…

Spectral Theory · Mathematics 2019-11-04 Joshua L. Mike , Jose A. Perea

Persistent homology is a cornerstone of topological data analysis, offering a multiscale summary of topology with robustness to nuisance transformations, such as rotations and small deformations. Persistent homology has seen broad use…

Methodology · Statistics 2025-11-19 Zitian Wu , Arkaprava Roy , Leo L. Duan

Topological Data Analysis (TDA) offers a suite of computational tools that provide quantified shape features in high dimensional data that can be used by modern statistical and predictive machine learning (ML) models. In particular,…

Cryptography and Security · Computer Science 2023-07-06 Dominic Gold , Koray Karabina , Francis C. Motta

Topological data analysis is becoming increasingly relevant to support the analysis of unstructured data sets. A common assumption in data analysis is that the data set is a sample---not necessarily a uniform one---of some high-dimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Markus Banagl , Filip Sadlo , Heike Leitte

Nonlinear dimensionality reduction methods provide a valuable means to visualize and interpret high-dimensional data. However, many popular methods can fail dramatically, even on simple two-dimensional manifolds, due to problems such as…

Machine Learning · Statistics 2020-07-08 Daniel Ting , Michael I. Jordan

This paper studies the homotopy-type of bi-filtrations of compact manifolds induced as the pre-image of filtrations of the plane for generic smooth functions f : M --> R^2. The primary goal of the paper is to allow for a simple description…

Algebraic Topology · Mathematics 2023-09-13 Ryan Budney , Tomasz Kaczynski

A central problem in data-driven scientific inquiry is how to interpret structure in noisy, high-dimensional data. Topological data analysis (TDA) provides a solution via persistent homology, which encodes features of interest as…

Algebraic Topology · Mathematics 2026-02-04 Christian Lentz , Gregory Henselman-Petrusek , Lori Ziegelmeier

Echoing recent calls to counter reliability and robustness concerns in machine learning via multiverse analysis, we present PRESTO, a principled framework for mapping the multiverse of machine-learning models that rely on latent…

Machine Learning · Computer Science 2024-06-04 Jeremy Wayland , Corinna Coupette , Bastian Rieck

A ReLU neural network leads to a finite polyhedral decomposition of input space and a corresponding finite dual graph. We show that while this dual graph is a coarse quantization of input space, it is sufficiently robust that it can be…

Algebraic Topology · Mathematics 2023-07-03 Yajing Liu , Christina M Cole , Chris Peterson , Michael Kirby

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

Computational topology provides a tool, persistent homology, to extract quantitative descriptors from structured objects (images, graphs, point clouds, etc). These descriptors can then be involved in optimization problems, typically as a…

Computational Geometry · Computer Science 2026-03-27 Mathieu Carriere , Yuichi Ike , Théo Lacombe , Naoki Nishikawa

We introduce a method for training neural networks to perform image or volume segmentation in which prior knowledge about the topology of the segmented object can be explicitly provided and then incorporated into the training process. By…

Computer Vision and Pattern Recognition · Computer Science 2020-09-21 James R. Clough , Nicholas Byrne , Ilkay Oksuz , Veronika A. Zimmer , Julia A. Schnabel , Andrew P. King

This paper introduces an unsupervised method to estimate the class separability of text datasets from a topological point of view. Using persistent homology, we demonstrate how tracking the evolution of embedding manifolds during training…

Machine Learning · Computer Science 2024-06-19 Kostis Gourgoulias , Najah Ghalyan , Maxime Labonne , Yash Satsangi , Sean Moran , Joseph Sabelja

This paper uses the technology of weighted and regular triangulations to study discrete versions of the Laplacian on piecewise Euclidean manifolds. Regular triangulations are studied in some detail, including flip algorithms. The Laplacian…

Metric Geometry · Mathematics 2007-05-23 David Glickenstein

Persistence homology is a tool used to measure topological features that are present in data sets and functions. Persistence pairs births and deaths of these features as we iterate through the sublevel sets of the data or function of…

Computational Geometry · Computer Science 2010-02-10 Brittany Terese Fasy

Capturing the dynamics of active particles, i.e., small self-propelled agents that both deform and are deformed by a fluid in which they move is a formidable problem as it requires coupling fine scale hydrodynamics with large scale…

Soft Condensed Matter · Physics 2025-09-09 Sadra Saremi , Amirhossein Ahmadkhan Kordbacheh

Through the use of examples, we explain one way in which applied topology has evolved since the birth of persistent homology in the early 2000s. The first applications of topology to data emphasized the global shape of a dataset, such as…

Algebraic Topology · Mathematics 2021-04-23 Henry Adams , Michael Moy
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