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Life science is entering a new era of petabyte-level sequencing data. Converting such big data to biological insights represents a huge challenge for computational analysis. To this end, we developed DeepMetabolism, a biology-guided deep…

Genomics · Quantitative Biology 2017-05-10 Weihua Guo , You Xu , Xueyang Feng

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Deep learning has dramatically improved the performance in many application areas such as image classification, object detection, speech recognition, drug discovery and etc since 2012. Where deep learning algorithms promise to discover the…

Image and Video Processing · Electrical Eng. & Systems 2020-03-25 X. F. Xu , S. Talbot , T. Selvaraja

Deep learning has become a powerful tool in computational biology, revolutionising the analysis and interpretation of biological data over time. In our article review, we delve into various aspects of deep learning in computational biology.…

State-of-the-art object detection and segmentation methods for microscopy images rely on supervised machine learning, which requires laborious manual annotation of training data. Here we present a self-supervised method based on time arrow…

Computer Vision and Pattern Recognition · Computer Science 2023-07-27 Benjamin Gallusser , Max Stieber , Martin Weigert

Large amounts of unlabelled data are commonplace for many applications in computational pathology, whereas labelled data is often expensive, both in time and cost, to acquire. We investigate the performance of unsupervised and supervised…

Computer Vision and Pattern Recognition · Computer Science 2019-07-27 Koen Dercksen , Wouter Bulten , Geert Litjens

Semi-supervised learning utilizes insights from unlabeled data to improve model generalization, thereby reducing reliance on large labeled datasets. Most existing studies focus on limited samples and fail to capture the overall data…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Xiuzhen Guo , Lianyuan Yu , Ji Shi , Na Lei , Hongxiao Wang

The integration of deep learning technologies in medical imaging aims to enhance the efficiency and accuracy of cancer diagnosis, particularly for pancreatic and breast cancers, which present significant diagnostic challenges due to their…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Minhee Jang , Juheon Son , Thanaporn Viriyasaranon , Junho Kim , Jang-Hwan Choi

Stable diffusion models have ushered in a new era of advancements in image generation, currently reigning as the state-of-the-art approach, exhibiting unparalleled performance. The process of diffusion, accompanied by denoising through…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Andras Horvath

DeepLab2 is a TensorFlow library for deep labeling, aiming to provide a state-of-the-art and easy-to-use TensorFlow codebase for general dense pixel prediction problems in computer vision. DeepLab2 includes all our recently developed…

The International Symposium on Biomedical Imaging (ISBI) held a grand challenge to evaluate computational systems for the automated detection of metastatic breast cancer in whole slide images of sentinel lymph node biopsies. Our team won…

Quantitative Methods · Quantitative Biology 2016-06-21 Dayong Wang , Aditya Khosla , Rishab Gargeya , Humayun Irshad , Andrew H. Beck

In recent years, machine learning has developed rapidly, enabling the development of applications with high levels of recognition accuracy relating to the use of speech and images. However, other types of data to which these models can be…

Machine Learning · Computer Science 2020-06-30 Kieran Woodward , Eiman Kanjo , Andreas Oikonomou

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are…

We address the problem of acoustic source separation in a deep learning framework we call "deep clustering." Rather than directly estimating signals or masking functions, we train a deep network to produce spectrogram embeddings that are…

Neural and Evolutionary Computing · Computer Science 2015-08-19 John R. Hershey , Zhuo Chen , Jonathan Le Roux , Shinji Watanabe

Label-efficient time series representation learning, which aims to learn effective representations with limited labeled data, is crucial for deploying deep learning models in real-world applications. To address the scarcity of labeled time…

Machine Learning · Computer Science 2024-07-25 Emadeldeen Eldele , Mohamed Ragab , Zhenghua Chen , Min Wu , Chee-Keong Kwoh , Xiaoli Li

Detection and differentiation of circulating tumor cells (CTCs) and non-CTCs in blood draws of cancer patients pose multiple challenges. While the gold standard relies on tedious manual evaluation of an automatically generated selection of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Hümeyra Husseini-Wüsthoff , Sabine Riethdorf , Andreas Schneeweiss , Andreas Trumpp , Klaus Pantel , Harriet Wikman , Maximilian Nielsen , René Werner

Early cancer detection remains one of the most critical challenges in modern healthcare, where delayed diagnosis significantly reduces survival outcomes. Recent advancements in artificial intelligence, particularly deep learning, have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Emmanuella Avwerosuoghene Oghenekaro

Semantic segmentation necessitates approaches that learn high-level characteristics while dealing with enormous amounts of data. Convolutional neural networks (CNNs) can learn unique and adaptive features to achieve this aim. However, due…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Hasan AlMarzouqi , Lyes Saad Saoud

Hematoxylin and Eosin (H&E)-stained images are commonly used to detect nuclear or cancerous regions in cells from images captured by a microscope. Identifying cancer cytoplasm is crucial for determining the type of cancer; hence, obtaining…

Image and Video Processing · Electrical Eng. & Systems 2025-07-08 Rebeka Sultana , Hibiki Horibe , Tomoaki Murakami , Ikuko Shimizu

In this paper, we present contemporary techniques for visualising the feature space of a deep learning image classification neural network. These techniques are viewed in the context of a feed-forward network trained to classify low…

Computer Vision and Pattern Recognition · Computer Science 2018-11-16 Ezra Webb , Cheng Lei , Chun-Jung Huang , Hirofumi Kobayashi , Hideharu Mikami , Keisuke Goda