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Protein mutations can have profound effects on biological function, making accurate prediction of property changes critical for drug discovery, protein engineering, and precision medicine. Current approaches rely on fine-tuning…

Machine Learning · Computer Science 2025-10-27 Srivathsan Badrinarayanan , Yue Su , Janghoon Ock , Alan Pham , Sanya Ahuja , Amir Barati Farimani

Metamorphic Testing (MT) is a testing technique that can effectively alleviate the oracle problem. MT uses Metamorphic Relations (MRs) to determine if a test case passes or fails. MRs specify how the outputs should vary in response to…

Software Engineering · Computer Science 2023-05-19 Alejandra Duque-Torres , Dietmar Pfahl , Claus Klammer , Stefan Fischer

This paper presents an automated tool called Morphy for datamorphic testing. It classifies software test artefacts into test entities and test morphisms, which are mappings on testing entities. In addition to datamorphisms, metamorphisms…

Software Engineering · Computer Science 2019-12-23 Hong Zhu , Ian Bayley , Dongmei Liu , Xiaoyu Zheng

This article discusses the challenges of testing software systems with increasingly integrated AI and LLM functionalities. LLMs are powerful but unreliable, and labeled ground truth for testing rarely scales. Metamorphic Testing solves this…

Software Engineering · Computer Science 2026-03-27 Valerio Terragni

Metamorphic Testing (MT) addresses the test oracle problem by examining the relations between inputs and outputs of test executions. Such relations are known as Metamorphic Relations (MRs). In current practice, identifying and selecting…

Software Engineering · Computer Science 2022-07-28 Alejandra Duque-Torres , Dietmar Pfahl , Rudolf Ramler , Claus Klammer

Metamorphic testing has become one mainstream technique to address the notorious oracle problem in software testing, thanks to its great successes in revealing real-life bugs in a wide variety of software systems. Metamorphic relations, the…

Software Engineering · Computer Science 2024-06-12 Rui Li , Huai Liu , Pak-Lok Poon , Dave Towey , Chang-Ai Sun , Zheng Zheng , Zhi Quan Zhou , Tsong Yueh Chen

Deepfakes utilise Artificial Intelligence (AI) techniques to create synthetic media where the likeness of one person is replaced with another. There are growing concerns that deepfakes can be maliciously used to create misleading and…

Computer Vision and Pattern Recognition · Computer Science 2022-06-02 Nyee Thoang Lim , Meng Yi Kuan , Muxin Pu , Mei Kuan Lim , Chun Yong Chong

Metamorphic testing is a popular approach that aims to alleviate the oracle problem in software testing. At the core of this approach are Metamorphic Relations (MRs), specifying properties that hold among multiple test inputs and…

Software Engineering · Computer Science 2024-06-06 Jon Ayerdi , Valerio Terragni , Gunel Jahangirova , Aitor Arrieta , Paolo Tonella

Regression is one of the most commonly used statistical techniques. However, testing regression systems is a great challenge because of the absence of test oracle in general. In this paper, we show that Metamorphic Testing is an effective…

Methodology · Statistics 2021-08-24 Quang-Hung Luu , Man F. Lau , Sebastian P. H. Ng , Tsong Yueh Chen

Metamorphic testing is a well known approach to tackle the oracle problem in software testing. This technique requires the use of source test cases that serve as seeds for the generation of follow-up test cases. Systematic design of test…

Software Engineering · Computer Science 2018-02-22 Prashanta Saha , Upulee Kanewala

Unsupervised machine learning is the training of an artificial intelligence system using information that is neither classified nor labeled, with a view to modeling the underlying structure or distribution in a dataset. Since unsupervised…

Software Engineering · Computer Science 2020-03-18 Xiaoyuan Xie , Zhiyi Zhang , Tsong Yueh Chen , Yang Liu , Pak-Lok Poon , Baowen Xu

Metamorphic testing seeks to validate software in the absence of test oracles. Our application domain is ocean modeling, where test oracles often do not exist, but where symmetries of the simulated physical systems are known. In this short…

Software Engineering · Computer Science 2020-09-04 Dilip J. Hiremath , Martin Claus , Wilhelm Hasselbring , Willi Rath

In many industrial domains, the Functional Mock-up Interface (FMI) is used to exchange simulation models as Functional Mock-up Units (FMUs) across different partners using various modelling tools. This opens up the possibilities for…

The remarkable success of AlphaFold2 in providing accurate atomic-level prediction of protein structures from their amino acid sequence has transformed approaches to the protein folding problem. However, its core paradigm of mapping one…

Applications · Statistics 2025-12-12 Yongkai Chen , Samuel WK Wong , SC Kou

This paper presents a data-driven framework to improve the trustworthiness of US tax preparation software systems. Given the legal implications of bugs in such software on its users, ensuring compliance and trustworthiness of tax…

Software Engineering · Computer Science 2023-02-14 Saeid Tizpaz-Niari , Verya Monjezi , Morgan Wagner , Shiva Darian , Krystia Reed , Ashutosh Trivedi

Security testing aims at verifying that the software meets its security properties. In modern Web systems, however, this often entails the verification of the outputs generated when exercising the system with a very large set of inputs.…

Software Engineering · Computer Science 2023-03-09 Nazanin Bayati Chaleshtari , Fabrizio Pastore , Arda Goknil , Lionel C. Briand

Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Recently, due to their capacity and representation ability, pre-trained protein language models have achieved state-of-the-art performance in…

Biomolecules · Quantitative Biology 2024-02-06 Ziyi Zhou , Liang Zhang , Yuanxi Yu , Mingchen Li , Liang Hong , Pan Tan

Metamorphic testing seeks to verify software in the absence of test oracles. Our application domain is ocean system modeling, where test oracles rarely exist, but where symmetries of the simulated physical systems are known. The input data…

Software Engineering · Computer Science 2021-03-18 Dilip Jagadeeshwarswamy Hiremath , Martin Claus , Wilhelm Hasselbring , Willi Rath

With the sharp rise in software dependability and failure cost, high quality has been in great demand. However, guaranteeing high quality in software systems which have grown in size and complexity coupled with the constraints imposed on…

Software Engineering · Computer Science 2016-01-08 Bassey Isong , Obeten Ekabua

Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conformation, overlooking the conformational…

Biomolecules · Quantitative Biology 2025-06-18 Advaith Maddipatla , Nadav Bojan Sellam , Meital Bojan , Sanketh Vedula , Paul Schanda , Ailie Marx , Alex M. Bronstein