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Mechanical properties of the tissue engineering scaffolds are known to play a crucial role in tissue regeneration. Here, we have utilized discrete network and finite element models to study fibrous scaffold mechanics and its dependence on…

Soft Condensed Matter · Physics 2025-01-15 Dhruba Jyoti Mech , Mohd Suhail Rizvi

Biological tissues exhibit diverse mechanical and rheological behaviors during morphogenesis. While much is known about tissue phase transitions controlled by structural order and cell mechanics, key questions regarding how tissue-scale…

Soft Condensed Matter · Physics 2026-04-29 Pengyu Yu , Fridtjof Brauns , M. Cristina Marchetti

We investigate the structure and equilibrium linear-response dynamics of suspensions of hard colloidal dumbbells using Brownian Dynamics computer simulations. The focus lies on the dense fluid and plastic crystal states of the colloids with…

Soft Condensed Matter · Physics 2015-07-10 Nils Heptner , Joachim Dzubiella

The design of complex materials and the formation of specific patterns often arise from the properties of the individual building blocks. In this respect, colloidal systems offer a unique opportunity because nowadays they can be synthesized…

Soft Condensed Matter · Physics 2022-03-01 Fabrizio Camerin , Emanuela Zaccarelli

An adhesively stressed thin film of a soft hydrogel confined between two rigid flat substrates auto-roughens with its dominant wavelength exhibiting pronounced dependence on the film thickness (H). A linear stability analysis confirmed that…

Soft Condensed Matter · Physics 2014-01-29 Aditi Chakrabarti , Manoj K. Chaudhury

How can dense biological tissue maintain sharp boundaries between coexisting cell populations? We explore this question within a simple vertex model for cells, focusing on the role of topology and tissue surface tension. We show that the…

Soft Condensed Matter · Physics 2018-02-07 Daniel M. Sussman , J. M. Schwarz , M. Cristina Marchetti , M. Lisa Manning

Thin-shell structures, found in biological systems such as beetle carapaces and widely used in aerospace, civil, and mechanical engineering, achieve remarkable strength-to-mass ratio given their slenderness and curved geometries. However,…

Applied Physics · Physics 2025-07-01 Ilyes Krida , Jacob Tang , Daniel Floryan , Tian Chen

Biomembranes and vesicles consisting of multiple phases can attain a multitude of shapes, undergoing complex shape transitions. We study a Cahn--Hilliard model on an evolving hypersurface coupled to Navier--Stokes equations on the surface…

Numerical Analysis · Mathematics 2019-11-01 John W. Barrett , Harald Garcke , Robert Nürnberg

Stochastic homogeneous hyperelastic solids are characterised by strain-energy densities where the parameters are random variables defined by probability density functions. These models allow for the propagation of uncertainties from input…

Classical Physics · Physics 2019-08-13 L. Angela Mihai , Danielle Fitt , Thomas E. Woolley , Alain Goriely

Time-dependent properties of the speckled intensity patterns created by scattering coherent radiation from materials undergoing spinodal decomposition are investigated by numerical integration of the Cahn-Hilliard-Cook equation. For binary…

Statistical Mechanics · Physics 2009-10-31 Gregory Brown , Per Arne Rikvold , Mark Sutton , Martin Grant

Cellular solids are known to exhibit size effects, i.e., differences in the apparent effective elastic moduli, when the specimen size becomes comparable to the cell size. The present contribution employs direct numerical simulations (DNS)…

Computational Physics · Physics 2021-01-05 Rinh Dinh Pham , Geralf Hütter

Cell deformability is an essential determinant for tissue-scale mechanical nature, such as fluidity and rigidity, and is thus crucial for understanding tissue homeostasis and stable developmental processes. However, numerical simulations…

Tissues and Organs · Quantitative Biology 2023-03-08 Nen Saito , Shuji Ishihara

The hallmark of topological phases is their robust boundary signature whose intriguing properties---such as the one-way transport on the chiral edge of a Chern insulator and the sudden disappearance of surface states forming open Fermi arcs…

Mesoscale and Nanoscale Physics · Physics 2017-09-08 Flore K. Kunst , Maximilian Trescher , Emil J. Bergholtz

Biological tissues exhibit complex behaviors with their dynamics often resembling inert soft matter such as liquids, polymers, colloids, and liquid crystals. These analogies enable physics-based approaches for investigations of emergent…

Holding a shell in their hands, one can apply six loads: three by pulling and shearing, and three by bending and twisting. Here, it is shown that the shell resists exactly three load cases and comply with the other three, provided the shell…

Mathematical Physics · Physics 2026-03-03 Hussein Nassar

Numerical modeling of strength and non-destructive testing of complex structures such as buildings, space rockets or oil reservoirs often involves calculations on extremely large grids. The modeling of elastic wave processes in solids…

Numerical Analysis · Mathematics 2025-09-12 Katerina Beklemysheva , Egor Michel , Andrey Ovsiannikov

Topology optimization is an important basis for the design of components. Here, the optimal structure is found within a design space subject to boundary conditions. Thereby, the specific material law has a strong impact on the final design.…

Computational Engineering, Finance, and Science · Computer Science 2024-04-29 Miriam Kick , Philipp Junker

The paper presents a new method for shape and topology optimization based on an efficient and scalable boundary integral formulation for elasticity. To optimize topology, our approach uses iterative extraction of isosurfaces of a…

Optimization and Control · Mathematics 2016-12-14 Igor Ostanin , Ivan Tsybulin , Mikhail Litsarev , Ivan Oseledets , Denis Zorin

Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Synthetic devices mimicking these structures could sensitively monitor these cellular functions…

Additive manufacturing methods together with topology optimization have enabled the creation of multiscale structures with controlled spatially-varying material microstructure. However, topology optimization or inverse design of such…

Materials Science · Physics 2024-08-28 Harikrishnan Vijayakumaran , Jonathan B. Russ , Glaucio H. Paulino , Miguel A. Bessa