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The inherent stochasticity of cellular processes leads to significant cell-to-cell variation in protein abundance. Although this noise has already been characterized and modeled, its broader implications and significance remain unclear. In…

Biological Physics · Physics 2023-07-10 Teresa W. Lo , Han Kyou James Choi , Dean Huang , Paul A. Wiggins

Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness…

Populations and Evolution · Quantitative Biology 2009-11-13 Kunihiko Kaneko

In the theory of random dynamical systems (RDS), individuals with different initial states follow a same law of motion that is stochastically changing with time | called extrinsic noise. In the present work, intrin- sic noises for each…

Probability · Mathematics 2018-06-21 Adrian Jarret

When cells collide, they often exhibit "contact inhibition of locomotion" (CIL), a behavior in which cells repolarize and migrate away from the site of contact. Experimental CIL outcomes are highly variable - why? Here, we develop a minimal…

Cell Behavior · Quantitative Biology 2026-04-22 Mariia Kryvoruchko , Brian A. Camley

The approximation and convergence properties of implicit neural representations (INRs) are known to be highly sensitive to parameter initialization strategies. While several data-driven initialization methods demonstrate significant…

Computer Vision and Pattern Recognition · Computer Science 2026-04-01 Kushal Vyas , Alper Kayabasi , Daniel Kim , Vishwanath Saragadam , Ashok Veeraraghavan , Guha Balakrishnan

Demographic noise has profound effects on evolutionary and population dynamics, as well as on chemical reaction systems and models of epidemiology. Such noise is intrinsic and due to the discreteness of the dynamics in finite populations.…

Physics and Society · Physics 2015-05-14 Tobias Galla

A central challenge in computational modeling of dynamic biological systems is parameter inference from experimental time course measurements. However, one would not only like to infer kinetic parameters but also study their variability…

Recently, the mysterious In-Context Learning (ICL) ability exhibited by Transformer architectures, especially in large language models (LLMs), has sparked significant research interest. However, the resilience of Transformers' in-context…

Computation and Language · Computer Science 2024-05-02 Chen Cheng , Xinzhi Yu , Haodong Wen , Jingsong Sun , Guanzhang Yue , Yihao Zhang , Zeming Wei

Intent Classification (IC) and Slot Labeling (SL) models, which form the basis of dialogue systems, often encounter noisy data in real-word environments. In this work, we investigate how robust IC/SL models are to noisy data. We collect and…

Computation and Language · Computer Science 2021-11-03 Sailik Sengupta , Jason Krone , Saab Mansour

Sensory neurons give highly variable responses to stimulation, which can limit the amount of stimulus information available to downstream circuits. Much work has investigated the factors that affect the amount of information encoded in…

Neurons and Cognition · Quantitative Biology 2017-04-20 Joel Zylberberg , Alexandre Pouget , Peter E. Latham , Eric Shea-Brown

Recurrent neural networks (RNNs) are complex dynamical systems, capable of ongoing activity without any driving input. The long-term behavior of free-running RNNs, described by periodic, chaotic and fixed point attractors, is controlled by…

Neurons and Cognition · Quantitative Biology 2021-08-06 Claus Metzner , Patrick Krauss

Identifying the right tools to express the stochastic aspects of neural activity has proven to be one of the biggest challenges in computational neuroscience. Even if there is no definitive answer to this issue, the most common procedure to…

Neurons and Cognition · Quantitative Biology 2016-02-12 Grégory Dumont , Jacques Henry , Carmen Oana Tarniceriu

Studies about the constructive aspects of noise and fluctuations in different non-linear systems have shown that the addition of external noise to systems with an intrinsic noise may result in a less noisy response. Recently, the…

Materials Science · Physics 2009-11-13 D. Persano Adorno , N. Pizzolato , B. Spagnolo

The archetypal system demonstrating stochastic resonance is nothing more than a threshold triggered device. It consists of a periodic modulated input and noise. Every time an output crosses the threshold the signal is recorded. Such a…

Statistical Mechanics · Physics 2014-01-10 Krzysztof Szczepaniec , Bartlomiej Dybiec

Living cells are continually exposed to environmental signals that vary in time. These signals are detected and processed by biochemical networks, which are often highly stochastic. To understand how cells cope with a fluctuating…

Molecular Networks · Quantitative Biology 2012-06-01 Wiet de Ronde , Filipe Tostevin , Pieter Rein ten Wolde

Neural networks have gained importance as the machine learning models that achieve state-of-the-art performance on large-scale image classification, object detection and natural language processing tasks. In this paper, we consider noisy…

Information Theory · Computer Science 2021-02-02 Chuteng Zhou , Quntao Zhuang , Matthew Mattina , Paul N. Whatmough

Noise is usually regarded as adversarial to extract the effective dynamics from time series, such that the conventional data-driven approaches usually aim at learning the dynamics by mitigating the noisy effect. However, noise can have a…

Adaptation and Self-Organizing Systems · Physics 2023-09-12 Zequn Lin , Zhaofan Lu , Zengru Di , Ying Tang

Deep Neural Networks (DNNs) have revolutionized a wide range of industries, from healthcare and finance to automotive, by offering unparalleled capabilities in data analysis and decision-making. Despite their transforming impact, DNNs face…

Machine Learning · Computer Science 2024-02-08 Zhenyu Liu , Garrett Gagnon , Swagath Venkataramani , Liu Liu

Stochastic resonance (SR) - a counter-intuitive phenomenon in which the signal due to a weak periodic force in a nonlinear system can be {\it enhanced} by the addition of external noise - is reviewed. A theoretical approach based on linear…

Noisy saltatory spike propagation along myelinated axons is studied within a stochastic Hodgkin-Huxley model. The intrinsic noise (whose strength is inverse proportional to the nodal membrane size) arising from fluctuations of the number of…

Biological Physics · Physics 2010-09-01 Yunyun Li , Gerhard Schmid , Peter Hanggi