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The shape of a molecule determines its physicochemical and biological properties. However, it is often underrepresented in standard molecular representation learning approaches. Here, we propose using the Euler Characteristic Transform…

Machine Learning · Computer Science 2025-07-08 Victor Toscano-Duran , Florian Rottach , Bastian Rieck

Accurate detection and segmentation of cell nuclei in volumetric (3D) fluorescence microscopy datasets is an important step in many biomedical research projects. Although many automated methods for these tasks exist, they often struggle for…

Computer Vision and Pattern Recognition · Computer Science 2020-06-16 Martin Weigert , Uwe Schmidt , Robert Haase , Ko Sugawara , Gene Myers

With the increase in the use of deep learning for computer-aided diagnosis in medical images, the criticism of the black-box nature of the deep learning models is also on the rise. The medical community needs interpretable models for both…

Image and Video Processing · Electrical Eng. & Systems 2020-12-21 Mookund Sureka , Abhijeet Patil , Deepak Anand , Amit Sethi

This paper features convolutional neural networks defined on hypercomplex algebras applied to classify lymphocytes in blood smear digital microscopic images. Such classification is helpful for the diagnosis of acute lymphoblast leukemia…

Computer Vision and Pattern Recognition · Computer Science 2024-01-05 Guilherme Vieira , Marcos Eduardo Valle

We propose a software platform that integrates methods and tools for multi-objective parameter auto- tuning in tissue image segmentation workflows. The goal of our work is to provide an approach for improving the accuracy of nucleus/cell…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-09 Luis F. R. Taveira , Tahsin Kurc , Alba C. M. A. Melo , Jun Kong , Erich Bremer , Joel H. Saltz , George Teodoro

Clear cell renal cell carcinoma (ccRCC) is one of the most common forms of intratumoral heterogeneity in the study of renal cancer. ccRCC originates from the epithelial lining of proximal convoluted renal tubules. These cells undergo…

Image and Video Processing · Electrical Eng. & Systems 2021-07-02 Shiba Kuanar , Vassilis Athitsos , Dwarikanath Mahapatra , Anand Rajan

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati

Automated detection of cervical cancer cells or cell clumps has the potential to significantly reduce error rate and increase productivity in cervical cancer screening. However, most traditional methods rely on the success of accurate cell…

Computer Vision and Pattern Recognition · Computer Science 2019-12-24 Yixiong Liang , Zhihong Tang , Meng Yan , Jialin Chen , Qing Liu , Yao Xiang

Galaxy morphology, a key tracer of the evolution of a galaxy's physical structure, has motivated extensive research on machine learning techniques for efficient and accurate galaxy classification. The emergence of quantum computers has…

Astrophysics of Galaxies · Physics 2023-11-08 Mohammad Hassan Hassanshahi , Marcin Jastrzebski , Sarah Malik , Ofer Lahav

Numerous phenomenological nuclear models have been proposed to describe specific observables within different regions of the nuclear chart. However, developing a unified model that describes the complex behavior of all nuclei remains an…

Nuclear Theory · Physics 2025-05-14 Jose M. Munoz , Silviu M. Udrescu , Ronald F. Garcia Ruiz

Nuclei segmentation is a fundamental but challenging task in the quantitative analysis of histopathology images. Although fully-supervised deep learning-based methods have made significant progress, a large number of labeled images are…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Xinyi Yu , Guanbin Li , Wei Lou , Siqi Liu , Xiang Wan , Yan Chen , Haofeng Li

The accurate classification of lymphoma subtypes using hematoxylin and eosin (H&E)-stained tissue is complicated by the wide range of morphological features these cancers can exhibit. We present LymphoML - an interpretable machine learning…

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Image and Video Processing · Electrical Eng. & Systems 2022-02-25 Satoshi Kondo , Satoshi Kasai

Automatic nuclei segmentation and classification play a vital role in digital pathology. However, previous works are mostly built on data with limited diversity and small sizes, making the results questionable or misleading in actual…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Kai Yao , Kaizhu Huang , Jie Sun , Amir Hussain

Multispectral images (e.g. visible and infrared) may be particularly useful when detecting objects with the same model in different environments (e.g. day/night outdoor scenes). To effectively use the different spectra, the main technical…

Computer Vision and Pattern Recognition · Computer Science 2020-09-29 Heng Zhang , Elisa Fromont , Sébastien Lefevre , Bruno Avignon

Brain tumor classification using MRI images is critical in medical diagnostics, where early and accurate detection significantly impacts patient outcomes. While recent advancements in deep learning (DL), particularly CNNs, have shown…

Image and Video Processing · Electrical Eng. & Systems 2025-03-03 Priyam Ganguly , Akhilbaran Ghosh

In image set classification, a considerable advance has been made by modeling the original image sets by second order statistics or linear subspace, which typically lie on the Riemannian manifold. Specifically, they are Symmetric Positive…

Computer Vision and Pattern Recognition · Computer Science 2018-05-31 Rui Wang , Xiao-Jun Wu , Kai-Xuan Chen , Josef Kittler

Multi-class cell nuclei detection is a fundamental prerequisite in the diagnosis of histopathology. It is critical to efficiently locate and identify cells with diverse morphology and distributions in digital pathological images. Most…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Junjia Huang , Haofeng Li , Xiang Wan , Guanbin Li

Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Simon Gutwein , Daria Lazic , Thomas Walter , Sabine Taschner-Mandl , Roxane Licandro

Identification and quantification of nuclei in colorectal cancer haematoxylin \& eosin (H\&E) stained histology images is crucial to prognosis and patient management. In computational pathology these tasks are referred to as nuclear…

Quantitative Methods · Quantitative Biology 2022-03-08 Muhammad Dawood , Raja Muhammad Saad Bashir , Srijay Deshpande , Manahil Raza , Adam Shephard
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