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The dynamics of adaptation is difficult to predict because it is highly stochastic even in large populations. The uncertainty emerges from number fluctuations, called genetic drift, arising in the small number of particularly fit…

Populations and Evolution · Quantitative Biology 2015-06-30 Oskar Hallatschek , Lukas Geyrhofer

Recent methods have been developed to map single-cell lineage statistics to population growth. Because population growth selects for exponentially rare phenotypes, these methods inherently depend on sampling large deviations from finite…

Statistical Mechanics · Physics 2025-01-16 Trevor GrandPre , Ethan Levien , Ariel Amir

Dispersal of species to find a more favorable habitat is important in population dynamics. Dispersal rates evolve in response to the relative success of different dispersal strategies. In a simplified deterministic treatment (J. Dockery, V.…

Populations and Evolution · Quantitative Biology 2009-07-28 David A. Kessler , Leonard M. Sander

Fluctuation dynamics of an experimentally measured observable offer a primary signal for nonequilibrium systems, along with dynamics of the mean. While universal speed limits for the mean have actively been studied recently, constraints for…

Statistical Mechanics · Physics 2024-11-08 Ryusuke Hamazaki

Biologically driven non-equilibrium fluctuations are often characterized by their non-Gaussianity or by an "effective temperature", which is frequency dependent and higher than the ambient temperature. We address these two measures…

Biological Physics · Physics 2011-06-16 Eyal Ben-Isaac , YongKeun Park , Gabriel Popescu , Frank L. H. Brown , Nir S. Gov , Yair Shokef

Gibbs and Boltzmann definitions of temperature agree only in the macroscopic limit. The ambiguity in identifying the equilibrium temperature of a finite sized `small' system exchanging energy with a bath is usually understood as a…

Biological Physics · Physics 2015-03-09 Purushottam D. Dixit

We consider a general class of Markovian models describing the growth in a randomly fluctuating environment of a clonal biological population having several phenotypes related by stochastic switching. Phenotypes differ e.g. by the level of…

Populations and Evolution · Quantitative Biology 2022-01-25 J. Unterberger

Given uncertainties in physical theory and numerical climate simulations, the historical temperature record is often used as a source of empirical information about climate change. Many historical trend analyses appear to deemphasize…

Applications · Statistics 2017-05-16 Andrew Poppick , Elisabeth J. Moyer , Michael L. Stein

McMullen et al. [1] comment that the numerical simulations that explicitly include random velocity fluctuations ``should exhibit a thermal-fluctuation-dominated range'' consistent with the literature, so that our results (J. Fluid Mech.…

Fluid Dynamics · Physics 2025-10-20 Shijun Liao , Shijie Qin

Thermodynamic parameters such as temperature and pressure can be defined from the statistical behavior of a system. Therefore, thermal fluctuation is an inseparable characteristic of these parameters which eventually finds its way into…

Computational Physics · Physics 2017-02-28 Alek Bedroya , Mahmud Bahmanabadi

This paper is devoted to provide a theoretical underpinning for ensemble forecasting with rapid fluctuations in body forcing and in boundary conditions. Ensemble averaging principles are proved under suitable `mixing' conditions on random…

Probability · Mathematics 2012-07-26 Wei Wang , Jian Ren , Jinqiao Duan , Guowei He

Nonlinear systems are capable of displaying complex behavior even if this is the result of a small number of interacting time scales. A widely studied case is when complex dynamics emerges out of a nonlinear system being forced by a simple…

Quantitative Methods · Quantitative Biology 2015-06-01 Leandro M. Alonso

In large asexual populations, multiple beneficial mutations arise in the population, compete, interfere with each other, and accumulate on the same genome, before any of them fix. The resulting dynamics, although studied by many authors, is…

Populations and Evolution · Quantitative Biology 2015-06-11 Daniel S. Fisher

The concept of fitness as a measure for a species's success in natural selection is central to the theory of evolution. We here investigate how reproduction rates which are not constant but vary in response to environmental fluctuations,…

Populations and Evolution · Quantitative Biology 2015-10-21 Anna Melbinger , Massimo Vergassola

Convective counterparts of variants of the nonlinear Fisher equation which describes reaction diffusion systems in population dynamics are studied with the help of an analytic prescription and shown to lead to interesting consequences for…

Populations and Evolution · Quantitative Biology 2007-05-23 Ignacio D. Peixoto , Luca Giuggioli , V. M. Kenkre

Using a population dynamics inspired by an ensemble of growing cells, a set of fluctuation theorems linking observables measured at the lineage and population levels are derived. One of these relations implies specific inequalities…

Populations and Evolution · Quantitative Biology 2021-11-08 Reinaldo García-García , Arthur Genthon , David Lacoste

Standard neutral population genetics theory with a strictly fixed population size has important limitations. An alternative model that allows independently fluctuating population sizes and reproduces the standard neutral evolution is…

Populations and Evolution · Quantitative Biology 2017-03-08 Thiparat Chotibut , David R. Nelson

Aleatoric uncertainty captures the inherent randomness of the data, such as measurement noise. In Bayesian regression, we often use a Gaussian observation model, where we control the level of aleatoric uncertainty with a noise variance…

Machine Learning · Computer Science 2022-03-31 Sanyam Kapoor , Wesley J. Maddox , Pavel Izmailov , Andrew Gordon Wilson

Empirical evidence shows that ensembles, such as bagging, boosting, random and rotation forests, generally perform better in terms of their generalization error than individual classifiers. To explain this performance, Schapire et al.…

Machine Learning · Statistics 2019-06-10 Waldyn Martinez , J. Brian Gray

Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in…

Populations and Evolution · Quantitative Biology 2018-08-15 Hong-Yan Shih , Harry Mickalide , David T. Fraebel , Nigel Goldenfeld , Seppe Kuehn
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