Related papers: Serostatus Testing & Dengue Vaccine Cost-Benefit T…
Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern. With 390 million infections annually and 96 million showing clinical symptoms, severe dengue can lead to life-threatening conditions like dengue…
Cancer Screening has been widely recognized as an effective strategy for preventing the disease. Despite its effectiveness, determining when to start screening is complicated, because starting too early increases the number of screenings…
The COVID-19 pandemic poses challenges for continuing economic activity while reducing health risks. While these challenges can be mitigated through testing, testing budget is often limited. Here we study how institutions, such as nursing…
Dengue is a serious health problem in the Philippines. In 2016, the Department of Health of the country launched a dengue vaccination campaign using Dengvaxia. However, the campaign was mired with controversy and the use of Dengvaxia was…
There are multiple testing methods to ascertain an infection in an individual and they vary in their performances, cost and delay. Unfortunately, better performing tests are sometimes costlier and time consuming and can only be done for a…
Test-negative designs (TNDs), a form of case-cohort study, are widely used to evaluate infectious disease interventions, notably for influenza and, more recently, COVID-19 vaccines. TNDs rely on recruiting individuals who are tested for the…
The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness against the risk of acquiring infectious diseases in real-world settings, such as Influenza, Rotavirus, Dengue fever, and more recently…
The test-negative design (TND) is widely used to evaluate vaccine effectiveness in real-world settings. In a TND study, individuals with similar symptoms who seek care are tested, and effectiveness is estimated by comparing vaccination…
As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of…
Effective and efficient scheduling of vaccine distribution can significantly impact vaccine uptake, which is critical to controlling the spread of infectious diseases. Ineffective scheduling can lead to waste, delays, and low vaccine…
If people at risk of HIV infection are tested annually and started on treatment as soon as they are found to be HIV-positive it should be possible to reduce the case reproduction number for HIV to less than one, eliminate transmission and…
Regular tuberculosis (TB) screening is required for healthcare employees since they can come into contact with infected patients. TB is a serious, contagious, and potentially deadly disease. Early detection of the disease, even when it is…
Improved hygiene and infant vaccinations have led to age specific variations in hepatitis A antibody prevalence in Korea, with lower rates among individuals in their 20s to 40s. Given that the fatality rate of hepatitis A increases for…
In 2019, the World Health Organization identified dengue as one of the top ten global health threats. For the control of dengue, the Applying Wolbachia to Eliminate Dengue (AWED) study group conducted a cluster-randomized trial in…
During an infectious disease outbreak, policymakers must balance medical costs with social and economic burdens and seek interventions that minimize both. To support this decision-making process, we developed a framework that integrates…
Testing is a crucial control mechanism in the beginning phase of an epidemic when the vaccines are not yet available. It enables the public health authority to detect and isolate the infected cases from the population, thereby limiting the…
In this paper, we extend the classical SIRS (Susceptible-Infectious-Recovered-Susceptible) model from mathematical epidemiology by incorporating a vaccinated compartment, V, accounting for an imperfect vaccine with waning efficacy over…
Dengue is the most prevalent arthropod-borne viral disease. Clinical symptoms of dengue virus (DENV) infection range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few…
Dengue viral infections show unique infection patterns arising from its four serot- ypes, (DENV-1,2,3,4). Its effects range from simple fever in primary infections to potentially fatal secondary infections. We analytically and numerically…
Testing is a crucial control mechanism for an epidemic outbreak because it enables the health authority to detect and isolate the infected cases, thereby limiting the disease transmission to susceptible people, when no effective treatment…