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Persistent homology is a method for computing the topological features present in a given data. Recently, there has been much interest in the integration of persistent homology as a computational step in neural networks or deep learning. In…

Machine Learning · Computer Science 2020-11-17 Padraig Corcoran , Bailin Deng

Persistent homology is an effective method for extracting topological information, represented as persistent diagrams, of spatial structure data. Hence it is well-suited for the study of protein structures. Attempts to incorporate…

Machine Learning · Computer Science 2024-08-01 An Wu , Yu Pan , Fuqi Zhou , Jinghui Yan , Chuanlu Liu

This article studies the robust version of persistent homology based on trimming methodology to capture the geometric feature through support of the data in presence of outliers. Precisely speaking, the proposed methodology works when the…

Methodology · Statistics 2026-01-01 Tuhin Subhra Mahato , Subhra Sankar Dhar

Quantification and classification of protein structures, such as knotted proteins, often requires noise-free and complete data. Here we develop a mathematical pipeline that systematically analyzes protein structures. We showcase this…

Hyperuniformity, the suppression of density fluctuations at large length scales, is observed across a wide variety of domains, from cosmology to condensed matter and biological systems. Although the standard definition of hyperuniformity…

Statistical Mechanics · Physics 2024-05-07 Marco Salvalaglio , Dominic J. Skinner , Jörn Dunkel , Axel Voigt

In this paper, we introduce multiscale persistent functions for biomolecular structure characterization. The essential idea is to combine our multiscale rigidity functions with persistent homology analysis, so as to construct a series of…

Biomolecules · Quantitative Biology 2016-12-28 Kelin Xia , Zhiming Li , Lin Mu

Persistent homology has been devised as a promising tool for the topological simplification of complex data. However, it is computationally intractable for large data sets. In this work, we introduce multiresolution persistent homology for…

Biomolecules · Quantitative Biology 2015-04-02 Kelin Xia , Zhixiong Zhao , Guo-Wei Wei

High-accuracy prediction of the physical properties of amorphous materials is challenging in condensed-matter physics. A promising method to achieve this is machine-learning potentials, which is an alternative to computationally demanding…

Machine Learning · Computer Science 2023-05-23 Emi Minamitani , Ippei Obayashi , Koji Shimizu , Satoshi Watanabe

Identifying molecular signatures from complex disease patients with underlying symptomatic similarities is a significant challenge in the analysis of high dimensional multi-omics data. Topological data analysis (TDA) provides a way of…

Genomics · Quantitative Biology 2024-04-23 Davide Gurnari , Aldo Guzmán-Sáenz , Filippo Utro , Aritra Bose , Saugata Basu , Laxmi Parida

Topological data analysis (TDA) is an area of data science that focuses on using invariants from algebraic topology to provide multiscale shape descriptors for geometric data sets such as point clouds. One of the most important such…

Computational Geometry · Computer Science 2023-06-21 David Loiseaux , Mathieu Carrière , Andrew J. Blumberg

Persistent homology provides a robust methodology to infer topological structures from point cloud data. Here we explore the persistent homology of point clouds embedded into a probabilistic setting, exploiting the theory of point…

Probability · Mathematics 2023-08-07 Daniel Spitz , Anna Wienhard

Persistent homology is a popular and useful tool for analysing finite metric spaces, revealing features that can be used to distinguish sets of unlabeled points and as input into machine learning pipelines. The famous stability theorem of…

Computational Geometry · Computer Science 2024-05-10 Philip Smith , Vitaliy Kurlin

Topological data analysis is a relatively new branch of machine learning that excels in studying high dimensional data, and is theoretically known to be robust against noise. Meanwhile, data objects with mixed numeric and categorical…

Algebraic Topology · Mathematics 2020-06-15 Chengyuan Wu , Carol Anne Hargreaves

Within the context of topological data analysis, the problems of identifying topological significance and matching signals across datasets are important and useful inferential tasks in many applications. The limitation of existing solutions…

Algebraic Topology · Mathematics 2024-06-26 Inés García-Redondo , Anthea Monod , Anna Song

Classifying images often requires manual identification of qualitative features. Machine learning approaches including convolutional neural networks can achieve accuracy comparable to human classifiers, but require extensive data and…

Atomic Physics · Physics 2022-09-05 Daniel Leykam , Irving Rondon , Dimitris G Angelakis

Persistent homology is a multiscale method for analyzing the shape of sets and functions from point cloud data arising from an unknown distribution supported on those sets. When the size of the sample is large, direct computation of the…

The local arrangement of atoms is one of the most important predictors of mechanical and functional properties of materials. However, algorithms for identifying the geometrical arrangements of atoms in complex materials systems are lacking.…

Materials Science · Physics 2019-04-15 Arash Dehghan Banadaki , Jason J. Maldonis , Paul M. Voyles , Srikanth Patala

Topological data analysis can extract effective information from higher-dimensional data. Its mathematical basis is persistent homology. The persistent homology can calculate topological features at different spatiotemporal scales of the…

Algebraic Topology · Mathematics 2023-09-29 Dinghua Shi , Zhifeng Chen , Chuang Ma , Guanrong Chen

Complex networks encountered in biology are often characterized by significant structural diversity. Whether it be differences in the three-dimensional structure of allosteric proteins, or the variation among the micro-scale structures of…

Physics and Society · Physics 2020-08-19 Jason W. Rocks , Andrea J. Liu , Eleni Katifori

Topological Data Analysis (TDA) is a novel statistical technique, particularly powerful for the analysis of large and high dimensional data sets. Much of TDA is based on the tool of persistent homology, represented visually via persistence…

Applications · Statistics 2017-11-07 Sarit Agami , Robert J. Adler