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Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology. Protein…

Biomolecules · Quantitative Biology 2015-10-06 Zixuan Cang , Lin Mu , Kedi Wu , Kristopher Opron , Kelin Xia , Guo-Wei Wei

Machine learning for point clouds has been attracting much attention, with many applications in various fields, such as shape recognition and material science. For enhancing the accuracy of such machine learning methods, it is often…

Machine Learning · Computer Science 2023-12-29 Naoki Nishikawa , Yuichi Ike , Kenji Yamanishi

This paper is a survey of persistent homology, primarily as it is used in topological data analysis. It includes the theory of persistence modules, as well as stability theorems for persistence barcodes, generalized persistence,…

Algebraic Topology · Mathematics 2020-04-03 Gunnar Carlsson

Persistent homology, a powerful mathematical tool for data analysis, summarizes the shape of data through tracking topological features across changes in different scales. Classical algorithms for persistent homology are often constrained…

Quantum Physics · Physics 2024-02-28 Bernardo Ameneyro , George Siopsis , Vasileios Maroulas

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington

Long lived topological features are distinguished from short lived ones (considered as topological noise) in simplicial complexes constructed from complex networks. A new topological invariant, persistent homology, is determined and…

Mathematical Physics · Physics 2009-11-13 Danijela Horak , Slobodan Maletic , Milan Rajkovic

Persistent homology is a topological feature used in a variety of applications such as generating features for data analysis and penalizing optimization problems. We develop an approach to accelerate persistent homology computations…

Algebraic Topology · Mathematics 2023-01-19 Yuan Luo , Bradley J. Nelson

Persistent homology is a popular and powerful tool for capturing topological features of data. Advances in algorithms for computing persistent homology have reduced the computation time drastically -- as long as the algorithm does not…

Computational Geometry · Computer Science 2013-10-03 Ulrich Bauer , Michael Kerber , Jan Reininghaus

Through the use of examples, we explain one way in which applied topology has evolved since the birth of persistent homology in the early 2000s. The first applications of topology to data emphasized the global shape of a dataset, such as…

Algebraic Topology · Mathematics 2021-04-23 Henry Adams , Michael Moy

Persistent homology is an important methodology in topological data analysis which adapts theory from algebraic topology to data settings. Computing persistent homology produces persistence diagrams, which have been successfully used in…

Machine Learning · Statistics 2026-01-13 Yueqi Cao , Anthea Monod

Persistent homology has emerged as a popular technique for the topological simplification of big data, including biomolecular data. Multidimensional persistence bears considerable promise to bridge the gap between geometry and topology.…

Biomolecules · Quantitative Biology 2014-12-25 Kelin Xia , Guo-Wei Wei

Many datasets can be viewed as a noisy sampling of an underlying space, and tools from topological data analysis can characterize this structure for the purpose of knowledge discovery. One such tool is persistent homology, which provides a…

Computational topology provides a tool, persistent homology, to extract quantitative descriptors from structured objects (images, graphs, point clouds, etc). These descriptors can then be involved in optimization problems, typically as a…

Computational Geometry · Computer Science 2026-03-27 Mathieu Carriere , Yuichi Ike , Théo Lacombe , Naoki Nishikawa

Persistent homology is a widely used tool in Topological Data Analysis that encodes multiscale topological information as a multi-set of points in the plane called a persistence diagram. It is difficult to apply statistical theory directly…

Statistics Theory · Mathematics 2013-12-03 Frédéric Chazal , Brittany Terese Fasy , Fabrizio Lecci , Alessandro Rinaldo , Larry Wasserman

Finding an optimal parameter of a black-box function is important for searching stable material structures and finding optimal neural network structures, and Bayesian optimization algorithms are widely used for the purpose. However, most of…

Machine Learning · Computer Science 2019-02-27 Tatsuya Shiraishi , Tam Le , Hisashi Kashima , Makoto Yamada

Persistent (co)homology is a central construction in topological data analysis, where it is used to quantify prominence of features in data to produce stable descriptors suitable for downstream analysis. Persistence is challenging to…

Computational Geometry · Computer Science 2024-10-23 Arnur Nigmetov , Dmitriy Morozov

In topological data analysis, persistent homology is used to study the "shape of data". Persistent homology computations are completely characterized by a set of intervals called a bar code. It is often said that the long intervals…

Computational Geometry · Computer Science 2025-02-19 Peter Bubenik , Michael Hull , Dhruv Patel , Benjamin Whittle

Persistent Homology is a powerful tool in Topological Data Analysis (TDA) to capture topological properties of data succinctly at different spatial resolutions. For graphical data, shape, and structure of the neighborhood of individual data…

Social and Information Networks · Computer Science 2018-11-12 Sumit Bhatia , Bapi Chatterjee , Deepak Nathani , Manohar Kaul

Persistent homology is a cornerstone of topological data analysis, offering a multiscale summary of topology with robustness to nuisance transformations, such as rotations and small deformations. Persistent homology has seen broad use…

Methodology · Statistics 2025-11-19 Zitian Wu , Arkaprava Roy , Leo L. Duan

In many applications concerning the comparison of data expressed by $\mathbb{R}^m$-valued functions defined on a topological space $X$, the invariance with respect to a given group $G$ of self-homeomorphisms of $X$ is required. While…

Algebraic Topology · Mathematics 2016-01-29 Patrizio Frosini , Grzegorz Jablonski