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Persistent homology is a powerful tool for characterizing the topology of a data set at various geometric scales. When applied to the description of molecular structures, persistent homology can capture the multiscale geometric features and…

Quantitative Methods · Quantitative Biology 2018-07-31 Zixuan Cang , Guo-Wei Wei

In this study, we present a novel molecular fingerprint generation method based on multiparameter persistent homology. This approach reveals the latent structures and relationships within molecular geometry, and detects topological features…

Biomolecules · Quantitative Biology 2023-11-21 Andac Demir , Bulent Kiziltan

Proteins are the most important biomolecules for living organisms. The understanding of protein structure, function, dynamics and transport is one of most challenging tasks in biological science. In the present work, persistent homology is,…

Biomolecules · Quantitative Biology 2014-12-10 Kelin Xia , Guo-Wei Wei

This work introduces a number of algebraic topology approaches, such as multicomponent persistent homology, multi-level persistent homology and electrostatic persistence for the representation, characterization, and description of small…

Quantitative Methods · Quantitative Biology 2018-02-07 Zixuan Cang , Lin Mu , Guowei Wei

Persistent homology captures the evolution of topological features of a model as a parameter changes. The most commonly used summary statistics of persistent homology are the barcode and the persistence diagram. Another summary statistic,…

Methodology · Statistics 2016-04-01 Violeta Kovacev-Nikolic , Peter Bubenik , Dragan Nikolić , Giseon Heo

We introduce a novel set of observables associated to the rapidly developing field of persistent homology for the quantitative characterization of nuclear collisions and their evolution. Persistent homology allows for the identification of…

Nuclear Theory · Physics 2023-01-04 Greg Hamilton , Travis Dore , Christopher Plumberg

Persistent homology, a technique from computational topology, has recently shown strong empirical performance in the context of graph classification. Being able to capture long range graph properties via higher-order topological features,…

Machine Learning · Computer Science 2024-12-20 Rubén Ballester , Bastian Rieck

A suitable feature representation that can both preserve the data intrinsic information and reduce data complexity and dimensionality is key to the performance of machine learning models. Deeply rooted in algebraic topology, persistent…

Algebraic Topology · Mathematics 2018-11-02 Chi Seng Pun , Kelin Xia , Si Xian Lee

Topological data analysis is becoming increasingly relevant to support the analysis of unstructured data sets. A common assumption in data analysis is that the data set is a sample---not necessarily a uniform one---of some high-dimensional…

Algebraic Topology · Mathematics 2021-01-20 Bastian Rieck , Markus Banagl , Filip Sadlo , Heike Leitte

In this paper, we systematically review weighted persistent homology (WPH) models and their applications in biomolecular data analysis. Essentially, the weight value, which reflects physical, chemical and biological properties, can be…

Biomolecules · Quantitative Biology 2019-03-08 Zhenyu Meng , D Vijay Anand , Yunpeng Lu , Jie Wu , Kelin Xia

Persistent homology is a popular tool in Topological Data Analysis. It provides numerical characteristics of data sets which reflect global geometric properties. In order to be useful in practice, for example for feature generation in…

Computational Geometry · Computer Science 2020-02-17 Boris Goldfarb

Persistent Homology (PH) is a fundamental tool in computational topology, designed to uncover the intrinsic geometric and topological features of data across multiple scales. Originating within the broader framework of Topological Data…

Algebraic Topology · Mathematics 2025-05-13 Aurelie Jodelle Kemme , Collins Amburo Agyingi

Topological data analysis and its main method, persistent homology, provide a toolkit for computing topological information of high-dimensional and noisy data sets. Kernels for one-parameter persistent homology have been established to…

Machine Learning · Computer Science 2019-06-06 René Corbet , Ulderico Fugacci , Michael Kerber , Claudia Landi , Bei Wang

Biomolecular structure comparison not only reveals evolutionary relationships, but also sheds light on biological functional properties. However, traditional definitions of structure or sequence similarity always involve superposition or…

Quantitative Methods · Quantitative Biology 2017-07-13 Kelin Xia

Persistent homology is a technique recently developed in algebraic and computational topology well-suited to analysing structure in complex, high-dimensional data. In this paper, we exposit the theory of persistent homology from first…

Applications · Statistics 2016-11-30 Matthew Pietrosanu

Understanding the protein folding process is an outstanding issue in biophysics; recent developments in molecular dynamics simulation have provided insights into this phenomenon. However, the large freedom of atomic motion hinders the…

Computational Physics · Physics 2020-06-18 Takashi Ichinomiya , Ippei Obayashi , Yasuaki Hiraoka

Persistent homology is a central methodology in topological data analysis that has been successfully implemented in many fields and is becoming increasingly popular and relevant. The output of persistent homology is a persistence diagram --…

Statistics Theory · Mathematics 2024-04-24 Konstantin Häberle , Barbara Bravi , Anthea Monod

Prediction and discovery of new materials with desired properties are at the forefront of quantum science and technology research. A major bottleneck in this field is the computational resources and time complexity related to finding new…

This paper introduces persistent homology, which is a powerful tool to characterize the shape of data using the mathematical concept of topology. We explain the fundamental idea of persistent homology from scratch using some examples. We…

Algebraic Topology · Mathematics 2022-05-25 Ippei Obayashi , Takenobu Nakamura , Yasuaki Hiraoka

This paper aims to discuss a method of quantifying the 'shape' of data, via a methodology called topological data analysis. The main tool within topological data analysis is persistent homology; this is a means of measuring the shape of…

Algebraic Topology · Mathematics 2022-09-14 Tristan Gowdridge , Nikolaos Devilis , Keith Worden
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