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In the context of the genome rearrangement problem, we analyze two well known models, namely the block transposition and the prefix block transposition models, by exploiting the connection with the notion of permutation pattern. More…

Combinatorics · Mathematics 2018-08-09 Giulio Cerbai , Luca Ferrari

Modellers of large scale genome rearrangement events, in which segments of DNA are inverted, moved, swapped, or even inserted or deleted, have found a natural syntax in the language of permutations. Despite this, there has been a wide range…

Other Quantitative Biology · Quantitative Biology 2016-10-04 Sangeeta Bhatia , Pedro Feijão , Andrew R. Francis

Genome rearrangement distances are an established method in genome comparison. Works in this area may include various rearrangement operations representing large-scale mutations, gene orientation information, the number of nucleotides in…

Data Structures and Algorithms · Computer Science 2026-01-01 Gabriel Siqueira , Alexsandro Oliveira Alexandrino , Zanoni Dias

Genome rearrangement has been an active area of research in computational comparative genomics for the last three decades. While initially mostly an interesting algorithmic endeavor, now the practical application by applying rearrangement…

Computational Complexity · Computer Science 2025-07-23 Luís Cunha , Thiago Lopes , Uéverton Souza , Leonard Bohnenkämper , Marília D. V. Braga , Jens Stoye

Genome rearrangements are events where large blocks of DNA exchange places during evolution. The analysis of these events is a promising tool for understanding evolutionary genomics, providing data for phylogenetic reconstruction based on…

Computational Complexity · Computer Science 2023-11-30 Luís Cunha , Ignasi Sau , Uéverton Souza

Considering a pair of genomes, the goal of rearrangement distance problems is to estimate how distant these genomes are from each other based on genome rearrangements. Seminal works in genome rearrangements assumed that both genomes being…

Data Structures and Algorithms · Computer Science 2024-05-21 Alexsandro Oliveira Alexandrino

A Genome rearrangement problem studies large-scale mutations on a set of DNAs in living organisms. Various rearrangements like reversals, transpositions, translocations, fissions, fusions, and combinations and different variations have been…

Discrete Mathematics · Computer Science 2022-05-11 Pramod P Nair

Understanding the dynamics of genome rearrangements is a major issue of phylogenetics. Phylogenetics is the study of species evolution. A major goal of the field is to establish evolutionary relationships within groups of species, in order…

Data Structures and Algorithms · Computer Science 2014-10-22 Antoine Thomas

Early literature on genome rearrangement modelling views the problem of computing evolutionary distances as an inherently combinatorial one. In particular, attention was given to estimating distances using the minimum number of events…

Populations and Evolution · Quantitative Biology 2023-01-12 Joshua Stevenson , Venta Terauds , Jeremy Sumner

There is a deep connection between permutations and trees. Certain sub-structures of permutations, called sub-permutations, bijectively map to sub-trees of binary increasing trees. This opens a powerful tool set to study enumerative and…

Combinatorics · Mathematics 2014-07-02 Filippo Disanto , Thomas Wiehe

In this paper we present a simple framework to study various distance problems of permutations, including the transposition and block-interchange distance of permutations as well as the reversal distance of signed permutations. These…

Combinatorics · Mathematics 2015-03-17 Ricky X. F. Chen , Christian M. Reidys

One of the main challenges in Computational Biology is to find the evolutionary distance between two organisms. In the field of comparative genomics, one way to estimate such distance is to find a minimum cost sequence of rearrangements…

Computational Complexity · Computer Science 2022-02-18 Alexsandro Oliveira Alexandrino , Andre Rodrigues Oliveira , Ulisses Dias , Zanoni Dias

Inversions, also sometimes called reversals, are a major contributor to variation among bacterial genomes, with studies suggesting that those involving small numbers of regions are more likely than larger inversions. Deletions may arise in…

Rings and Algebras · Mathematics 2023-07-11 Chad Clark , Julius Jonušas , James D. Mitchell , Andrew Francis

Perfect sorting by reversals, a problem originating in computational genomics, is the process of sorting a signed permutation to either the identity or to the reversed identity permutation, by a sequence of reversals that do not break any…

Discrete Mathematics · Computer Science 2012-01-05 Mathilde Bouvel , Cedric Chauve , Marni Mishna , Dominique Rossin

We consider two related problems arising from a question of R. Graham on quasirandom phenomena in permutation patterns. A ``pattern'' in a permutation $\sigma$ is the order type of the restriction of $\sigma : [n] \to [n]$ to a subset $S…

Combinatorics · Mathematics 2008-01-29 Joshua Cooper , Andrew Petrarca

In this paper, we present an algorithm that enumerates a certain class of signed permutations, referred to as grid signed permutation classes. In the case of permutations, the corresponding grid classes are of interest because they are…

Combinatorics · Mathematics 2023-06-02 Saúl A. Blanco , Daniel E. Skora

Of the many modern approaches to calculating evolutionary distance via models of genome rearrangement, most are tied to a particular set of genomic modelling assumptions and to a restricted class of allowed rearrangements. The "position…

Populations and Evolution · Quantitative Biology 2021-11-15 Venta Terauds , Joshua Stevenson , Jeremy Sumner

This dissertation presents a multifaceted look into the structural decomposition of permutation classes. The theory of permutation patterns is a rich and varied field, and is a prime example of how an accessible and intuitive definition…

Combinatorics · Mathematics 2014-10-13 Cheyne Homberger

We define a map between the set of permutations that avoid either the four patterns $3214,3241,4213,4231$ or $3124,3142,4123,4132$, and the set of Dyck prefixes. This map, when restricted to either of the two classes, turns out to be a…

Combinatorics · Mathematics 2013-01-10 Marilena Barnabei , Flavio Bonetti , Matteo Silimbani

A permutation may be represented by a collection of paths in the plane. We consider a natural class of such representations, which we call tangles, in which the paths consist of straight segments at 45 degree angles, and the permutation is…

Discrete Mathematics · Computer Science 2013-06-19 Sergey Bereg , Alexander E. Holroyd , Lev Nachmanson , Sergey Pupyrev
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