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In this paper we describe a combined combinatorial/numerical approach to studying equilibria and bifurcations in network models arising in Systems Biology. ODE models of the dynamics suffer from high dimensional parameters which presents a…

Dynamical Systems · Mathematics 2024-11-28 Shane Kepley , Konstantin Mischaikow , Elena Queirolo

A fundamental question in biology is how cell populations evolve into different subtypes based on homogeneous processes at the single cell level. Here we show that population bimodality can emerge even when biological processes are…

Molecular Networks · Quantitative Biology 2019-07-01 Jorge Fernandez-de-Cossio-Diaz , Roberto Mulet , Alexei Vazquez

In stochastic population dynamics, stochastic wandering can produce transition to an absorbing state. In particular, under Allee effects, low densities amplify the possibility of population collapse. We investigate this in an…

Populations and Evolution · Quantitative Biology 2026-01-13 Luis F. Gordillo , Priscilla E. Greenwood

We consider a linear size-structured population model with diffusion in the size-space. Individuals are recruited into the population at arbitrary sizes. The model is equipped with generalized Wentzell-Robin (or dynamic) boundary…

Analysis of PDEs · Mathematics 2019-03-25 J. Z. Farkas , P. Hinow

Spatial metapopulation models are fundamental to theoretical ecology, enabling to study how landscape structure influences global species dynamics. Traditional models, including recent generalizations, often rely on the deterministic limit…

Populations and Evolution · Quantitative Biology 2025-06-24 Alice Doimo , Giorgio Nicoletti , Davide Bernardi , Prajwal Padmanabha

Most population models assume that individuals within a given population are identical, that is, the fundamental role of variation is ignored. Inhomogeneous models of populations and communities allow for birth and death rates to vary among…

Populations and Evolution · Quantitative Biology 2007-05-23 Georgy P. Karev

Infinitely many distinct trait values may arise in populations bearing quantitative traits, and modeling their population dynamics is thus a formidable task. While classical models assume fixed or infinite population size, models in which…

Populations and Evolution · Quantitative Biology 2025-05-08 Ananda Shikhara Bhat

Stochastic particle--based models are useful tools for describing the collective movement of large crowds of pedestrians in crowded confined environments. Using descriptions based on the simple exclusion process, two populations of…

Statistical Mechanics · Physics 2020-08-26 Emilio N. M. Cirillo , Matteo Colangeli , Adrian Muntean , T. K. Thoa Thieu

We consider a stochastic version of the Wilson-Cowan model which accommodates for discrete populations of excitatory and inhibitory neurons. The model assumes a finite carrying capacity with the two populations being constant in size. The…

Disordered Systems and Neural Networks · Physics 2016-11-02 Clement Zankoc , Tommaso Biancalani , Duccio Fanelli , Roberto Livi

Multimodal optimization requires finding many optima rather than merely keeping a diverse population. Yet most niching-based evolutionary algorithms rely on distances or density estimators without explicitly recovering the underlying…

Neural and Evolutionary Computing · Computer Science 2026-05-19 Meng Xiang , Pei Yan

We analyse the long term behaviour of the measure-valued solutions of a class of linear renewal equations modelling physiologically structured populations. The renewal equations that we consider are characterised by a regularisation…

Analysis of PDEs · Mathematics 2022-06-01 Eugenia Franco , Odo Diekmann , Mats Gyllenberg

A class of coupled cell-bulk ODE-PDE models is formulated and analyzed in a two-dimensional domain, which is relevant to studying quorum sensing behavior on thin substrates. In this model, spatially segregated dynamically active signaling…

Pattern Formation and Solitons · Physics 2016-05-04 J. Gou , M. J. Ward

The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic…

Cell Behavior · Quantitative Biology 2016-06-22 Benjamin Pfeuty , Kunihiko Kaneko

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

Neurons and Cognition · Quantitative Biology 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

We study a spatially explicit harvesting model in periodic or bounded environments. The model is governed by a parabolic equation with a spatially dependent nonlinearity of Kolmogorov--Petrovsky--Piskunov type, and a negative external…

Analysis of PDEs · Mathematics 2010-06-15 Lionel Roques , Mickaël D. Chekroun

In this paper we study the dynamics of a fast-slow Fokker-Planck partial differential equation (PDE) viewed as the evolution equation for the density of a multiscale planar stochastic differential equation (SDE). Our key focus is on the…

Analysis of PDEs · Mathematics 2025-02-03 Christian Kuehn , Jan-Eric Sulzbach

We review and extend results for mutation, selection, genetic drift, and migration in a one-dimensional continuous population. The population is described by a continuous limit of the stepping stone model, which leads to the stochastic…

Populations and Evolution · Quantitative Biology 2011-04-14 K. S. Korolev , Mikkel Avlund , Oskar Hallatschek , David R. Nelson

We study the population profile in a simple discrete time model of population dynamics. Our model, which is closely related to certain ``bit-string'' models of evolution, incorporates competition for resources via a population dependent…

Statistical Mechanics · Physics 2009-10-31 Martin Howard , R. K. P. Zia

In particle systems, flocking refers to the phenomenon where particles' individual velocities eventually align. The Cucker-Smale model is a well-known mathematical framework that describes this behavior. Many continuous descriptions of the…

Analysis of PDEs · Mathematics 2024-07-29 Sebastian Zimper , Federico Cornalba , Nataša Djurdjevac Conrad , Ana Djurdjevac

We are interested in modeling some two-level population dynamics, resulting from the interplay of ecological interactions and phenotypic variation of individuals (or hosts) and the evolution of cells (or parasites) of two types living in…

Probability · Mathematics 2011-01-21 Sylvie Méléard , Sylvie Roelly