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Complex field imaging, which captures both the amplitude and phase information of input optical fields or objects, can offer rich structural insights into samples, such as their absorption and refractive index distributions. However,…

Optics · Physics 2024-05-30 Jingxi Li , Yuhang Li , Tianyi Gan , Che-Yung Shen , Mona Jarrahi , Aydogan Ozcan

In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase…

Optics · Physics 2020-12-17 Xi Chen , Mikhail E. Kandel , Gabriel Popescu

Quantum spectroscopy seeks to probe chemical systems using nonclassical light, which has properties that are qualitatively and quantitatively different than conventional light sources. One promising technique uses intensity-correlated twin…

The ability to resolve and quantify features at submicrometer scales from a single-shot image is crucial for real-time uncovering intricate structures in unlabeled biological samples and analyzing them at the subcellular level. We introduce…

Optics · Physics 2025-01-22 Jaromír Běhal , Miroslav Ježek

Mid-infrared spectroscopic imaging (MIRSI) is an emerging class of label-free techniques being leveraged for digital histopathology. Modern histopathologic identification of ovarian cancer involves tissue staining followed by morphological…

I present a concise, first principles metrological framework for imaging dielectric biomaterials by probing the full phase space (Wigner) distribution of a quantum electromagnetic field. Building on a rigorous multilayer Maxwell and Cole…

Optics · Physics 2025-09-03 Alessandro Settimi

Fourier ptychographic microscopy (FPM) is a pivotal computational imaging technique that achieves phase and amplitude reconstruction with high resolution and wide field of view, using low numerical aperture objectives and LED array…

Optical microscopy has been employed to derive salient characteristics of an object in various fields, including cell biology, flow cytometry, biopsy, and neuroscience. In particular, measuring the phase of light scattered from an object…

Optics · Physics 2025-03-18 Jeonghun Oh , Herve Hugonnet , Weisun Park , YongKeun Park

High-resolution chemical imaging within deep tissues and intact spheroids remains a grand challenge. Here, we introduce mid-wave infrared photothermal (MWIP) microscopy operating in the underexplored 2000-2500 nm spectral window for…

Quantum imaging employs the nonclassical correlation of photons to break through the noise limitation of classical imaging, realizing high sensitivity, high SNR imaging and multifunctional image processing. To enhance the flexibility and…

Investigation of cell structure is hardly imaginable without bright-field microscopy. Numerous modifications such as depth-wise scanning or videoenhancement make this method being state-of-the-art. This raises a question what maximal…

Image and Video Processing · Electrical Eng. & Systems 2020-10-29 Kirill Lonhus , Renata Rychtarikova , Ganna Platonova , Dalibor Stys

We present an algorithm for coherent diffractive imaging with phaseless measurements. It treats the forward model as a combination of coherent and incoherent waves. The algorithm reconstructs absorption and phase contrast that quantifies…

Computational Physics · Physics 2022-08-25 Miguel Moscoso , Alexei Novikov , George Papanicolaou , Chrysoula Tsogka

Quantitative susceptibility mapping (QSM) utilizes MRI signal phase to infer estimates of local tissue magnetism (magnetic susceptibility), which has been shown useful to provide novel image contrast and as biomarkers of abnormal tissue.…

Medical Physics · Physics 2019-04-16 Juan Liu , Kevin M. Koch

Quasiparticle interference (QPI) of the electronic states has been widely applied in scanning tunneling microscopy (STM) to analyze the electronic band structure of materials. Single-defect induced QPI reveals defect-dependent interaction…

Materials Science · Physics 2020-07-08 Wenhao Zhang , Kunliang Bu , Fangzhou Ai , Zongxiu Wu , Ying Fei , Yuan Zheng , Jianhua Du , Minghu Fang , Yi Yin

The ability to perform high-precision optical measurements is paramount to science and engineering. Laser interferometry enables interaction-free sensing with a precision ultimately limited by shot noise. Quantum optical sensors can surpass…

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Spectral imaging in the mid-infrared (MIR) range provides simultaneous morphological and chemical information of a wide variety of samples. However, current MIR technologies struggle to produce high-definition images over a broad spectral…

Accurate assessment of burn severity at injury onset remains a major clinical challenge due to the lack of objective methods for detecting subsurface tissue damage. This limitation is critical in battlefield and mass-casualty settings,…

Image and Video Processing · Electrical Eng. & Systems 2025-11-26 Nathaniel Hanson , Mateusz Wolak , Jonathan Richardson , Patrick Walker , David M. Burmeister , Chakameh Jafari

Interferometric scattering microscopy has been a very promising technology for highly sensitive label-free imaging of a broad spectrum of biological nanoparticles from proteins to viruses in a high-throughput manner. Although it can reveal…

Optics · Physics 2021-08-11 Celalettin Yurdakul , Haonan Zong , Yeran Bai , Ji-Xin Cheng , M. Selim Unlu

In this work, a general theoretical framework is presented to explain the formation of the phase signal in an X-ray microscope integrated with a grating interferometer, which simultaneously enables the high spatial resolution imaging and…

Optics · Physics 2022-09-28 Jiecheng Yang , Yongshuai Ge , Dong Liang , Hairong Zheng