Related papers: The self-tuned sensitivity of circadian clocks
Time awareness is critical to a broad range of emerging applications -- in Cyber-Physical Systems and Internet of Things -- running on commodity platforms and operating systems. Traditionally, time is synchronized across devices through a…
The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a…
Biochemical circadian rhythm oscillations play an important role in many signalling mechanisms. In this work, we explore some of the biophysical mechanisms responsible for sustaining robust oscillations by constructing a minimal but…
The gene networks that comprise the circadian clock modulate biological function across a range of scales, from gene expression to performance and adaptive behaviour. The clock functions by generating endogenous rhythms that can be…
Adapting to regularities of the environment is critical for biological organisms to anticipate events and plan. A prominent example is the circadian rhythm corresponding to the internalization by organisms of the $24$-hour period of the…
Decoherence of quantum systems due to uncontrolled fluctuations of the environment presents fundamental obstacles in quantum science. `Clock' transitions which are insensitive to such fluctuations are used to improve coherence, however,…
The cyanobacterium Synechococcus elongatus uses both a protein phosphorylation cycle and a transcription-translation cycle to generate circadian rhythms that are highly robust against biochemical noise. We use stochastic simulations to…
Being able to measure time, whether directly or indirectly, is a significant advantage for an organism. It permits it to predict regular events, and prepare for them on time. Thus, clocks are ubiquitous in biology. In the present paper, we…
Circadian rhythms are biological rhythms of approximately 24 h that persist even under constant conditions without environmental daily cues. The molecular circadian clock machinery generates the physiological rhythms, which can be…
Periodic forcing of nonlinear oscillators leads to a large number of dynamic behaviors. The coupling of the cell-cycle to the circadian clock provides a biological realization of such forcing. Using high throughput single-cell microscopy,…
Observations that rates of molecular evolution vary widely within and among lineages have cast doubts upon the existence of a single molecular clock. Differences in the timing of evolutionary events estimated from genetic and fossil…
Biological systems display impressive capabilities in effectively responding to environmental signals in real time. There is increasing evidence that organisms may indeed be employing near optimal Bayesian calculations in their…
Adaptation is used by biological sensory systems to respond to a wide range of environmental signals, by adapting their response properties to the statistics of the stimulus in order to maximize information transmission. We derive rules of…
Sensory adaptation enables organisms to adjust their perception in a changing environment. A paradigm is bacterial chemotaxis, where the output activity of chemoreceptors is adapted to different baseline concentrations via receptor…
We consider the External Clock Synchronization problem in dynamic sensor networks. Initially, sensors obtain inaccurate estimations of an external time reference and subsequently collaborate in order to synchronize their internal clocks…
Cells generally convert nutrient resources to useful products via energy transduction. Accordingly, the thermodynamic efficiency of this conversion process is one of the most essential characteristics of living organisms. However, although…
Clock synchronization is critically important in positioning, navigation and timing systems. While its performance has been intensively studied in a wide range of disciplines, much less is known for the fundamental thermodynamics of clock…
According to thermodynamics, the inevitable increase of entropy allows the past to be distinguished from the future. From this perspective, any clock must incorporate an irreversible process that allows this flow of entropy to be tracked.…
We examine the stochastic dynamics of two enzymes that are mechanically coupled to each other, e.g., through an elastic substrate or a fluid medium. The enzymes undergo conformational changes during their catalytic cycle, which itself is…
Much work has been done to investigate social jetlag, a misalignment between the biological clock and the social agenda caused by exposition to different light inputs, that causes several health issues. To investigate synchronization and…