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Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data…

While reduction in feature size makes computation cheaper in terms of latency, area, and power consumption, performance of emerging data-intensive applications is determined by data movement. These trends have introduced the concept of…

Hardware Architecture · Computer Science 2018-03-19 Bahar Asgari , Saibal Mukhopadhyay , Sudhakar Yalamanchili

Processing-in-memory (PIM) reduces data movement by executing near memory, but our large-scale characterization on real PIM hardware shows that end-to-end performance is often limited by disjoint host and device address spaces that force…

Emerging Technologies · Computer Science 2025-11-20 I-Ting Lee , Bao-Kai Wang , Liang-Chi Chen , Wen Sheng Lim , Da-Wei Chang , Yu-Ming Chang , Chieng-Chung Ho

In-DRAM Processing-In-Memory (DRAM-PIM) has emerged as a promising approach to accelerate memory-intensive workloads by mitigating data transfer overhead between DRAM and the host processor. Bit-serial DRAM-PIM architectures, further…

Hardware Architecture · Computer Science 2025-12-11 Siyuan Ma , Jiajun Hu , Jeeho Ryoo , Aman Arora , Lizy Kurian John

Computing-In-Memory (CIM) offers a potential solution to the memory wall issue and can achieve high energy efficiency by minimizing data movement, making it a promising architecture for edge AI devices. Lightweight models like MobileNet and…

Hardware Architecture · Computer Science 2025-08-21 Choongseok Song , Doo Seok Jeong

Processing-in-memory (PIM) architectures have demonstrated great potential in accelerating numerous deep learning tasks. Particularly, resistive random-access memory (RRAM) devices provide a promising hardware substrate to build PIM…

Hardware Architecture · Computer Science 2022-02-01 Weidong Cao , Yilong Zhao , Adith Boloor , Yinhe Han , Xuan Zhang , Li Jiang

Memory system is often the main bottleneck in chipmultiprocessor (CMP) systems in terms of latency, bandwidth and efficiency, and recently additionally facing capacity and power problems in an era of big data. A lot of research works have…

Hardware Architecture · Computer Science 2014-04-10 Licheng Chen , Tianyue Lu , Yanan Wang , Mingyu Chen , Yuan Ruan , Zehan Cui , Yongbing Huang , Mingyang Chen , Jiutian Zhang , Yungang Bao

Computing is bottlenecked by data. Large amounts of application data overwhelm storage capability, communication capability, and computation capability of the modern machines we design today. We argue that an intelligent architecture should…

Hardware Architecture · Computer Science 2020-12-24 Onur Mutlu

Modern Artificial Intelligence (AI) applications are increasingly utilizing multi-tenant deep neural networks (DNNs), which lead to a significant rise in computing complexity and the need for computing parallelism. ReRAM-based…

Emerging Technologies · Computer Science 2024-08-12 Bojing Li , Duo Zhong , Xiang Chen , Chenchen Liu

The quest for energy-efficient, scalable neuromorphic computing has elevated compute-in-memory (CIM) architectures to the forefront of hardware innovation. While memristive memories have been extensively explored for synaptic implementation…

Materials Science · Physics 2025-08-20 Kapil Bhardwaj , Ella Paasio , Sayani Majumdar

The widespread adoption of Large Language Models (LLMs) has exponentially increased the demand for efficient serving systems. With growing requests and context lengths, key-value (KV)-related operations, including attention computation and…

Hardware Architecture · Computer Science 2026-02-13 Lian Liu , Shixin Zhao , Yutian Zhou , Yintao He , Mengdi Wang , Yinhe Han , Ying Wang

The widespread adoption of cloud-based solutions introduces privacy and security concerns. Techniques such as homomorphic encryption (HE) mitigate this problem by allowing computation over encrypted data without the need for decryption.…

Cryptography and Security · Computer Science 2024-12-13 Mpoki Mwaisela , Joel Hari , Peterson Yuhala , Jämes Ménétrey , Pascal Felber , Valerio Schiavoni

Sequence alignment is a memory bound computation whose performance in modern systems is limited by the memory bandwidth bottleneck. Processing-in-memory architectures alleviate this bottleneck by providing the memory with computing…

Hardware Architecture · Computer Science 2023-03-28 Safaa Diab , Amir Nassereldine , Mohammed Alser , Juan Gómez-Luna , Onur Mutlu , Izzat El Hajj

In-memory computing is an emerging computing paradigm that overcomes the limitations of exiting Von-Neumann computing architectures such as the memory-wall bottleneck. In such paradigm, the computations are performed directly on the data…

Emerging Technologies · Computer Science 2022-04-14 Mohammed E. Fouda , Hasan Erdem Yantir , Ahmed M. Eltawil , Fadi Kurdahi

Our goal in this dissertation is to provide tools, programming models, and system support for PIM architectures (with a focus on DRAM-based solutions), to ease the adoption of PIM in current and future systems. To this end, we make at least…

Hardware Architecture · Computer Science 2025-08-28 Geraldo F. Oliveira

Training machine learning (ML) algorithms is a computationally intensive process, which is frequently memory-bound due to repeatedly accessing large training datasets. As a result, processor-centric systems (e.g., CPU, GPU) suffer from…

Hardware Architecture · Computer Science 2023-09-07 Juan Gómez-Luna , Yuxin Guo , Sylvan Brocard , Julien Legriel , Remy Cimadomo , Geraldo F. Oliveira , Gagandeep Singh , Onur Mutlu

Response time requirements for big data processing systems are shrinking. To meet this strict response time requirement, many big data systems store all or most of their data in main memory to reduce the access latency. Main memory…

Hardware Architecture · Computer Science 2016-08-29 Jason Lowe-Power , Mark D. Hill , David A. Wood

Triangles are the basic substructure of networks and triangle counting (TC) has been a fundamental graph computing problem in numerous fields such as social network analysis. Nevertheless, like other graph computing problems, due to the…

Hardware Architecture · Computer Science 2021-12-02 Xueyan Wang , Jianlei Yang , Yinglin Zhao , Xiaotao Jia , Rong Yin , Xuhang Chen , Gang Qu , Weisheng Zhao

Homomorphic encryption (HE) enables computation over encrypted data, offering strong privacy guarantees for untrusted computing environments. Practical adoption remains limited by high computational complexity, large ciphertext sizes, and…

Processing-in-memory (PIM), as a novel computing paradigm, provides significant performance benefits from the aspect of effective data movement reduction. SRAM-based PIM has been demonstrated as one of the most promising candidates due to…

Hardware Architecture · Computer Science 2023-11-01 Cenlin Duan , Jianlei Yang , Xiaolin He , Yingjie Qi , Yikun Wang , Yiou Wang , Ziyan He , Bonan Yan , Xueyan Wang , Xiaotao Jia , Weitao Pan , Weisheng Zhao