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Spatial transcriptomics studies are becoming increasingly large and commonplace, necessitating simultaneous analysis of a large number of spatially resolved variables. Correspondingly, a diverse range of methodologies have been proposed to…

Quantitative Methods · Quantitative Biology 2025-09-09 James Boyle , Gregory Hamm , Eleanor Williams , Robin JG Hartman , Magnus Soderburg , Ian Henry , Michael Casey

High-accuracy prediction of the physical properties of amorphous materials is challenging in condensed-matter physics. A promising method to achieve this is machine-learning potentials, which is an alternative to computationally demanding…

Machine Learning · Computer Science 2023-05-23 Emi Minamitani , Ippei Obayashi , Koji Shimizu , Satoshi Watanabe

Let $K$ be a finite simplicial, cubical, delta or CW complex. The persistence map $\mathrm{PH}$ takes a filter $f:K \rightarrow \mathbb{R}$ as input and returns the barcodes $\mathrm{PH}(f)$ of the associated sublevel set persistent…

Computational Geometry · Computer Science 2021-10-29 Jacob Leygonie , Gregory Henselman-Petrusek

In this paper we develop the theory of weighted persistent homology. In 1990, Robert J. Dawson was the first to study in depth the homology of weighted simplicial complexes. We generalize the definitions of weighted simplicial complex and…

Algebraic Topology · Mathematics 2019-04-09 Shiquan Ren , Chengyuan Wu , Jie Wu

Persistent homology has been studied to better understand the structural properties and topology features of weighted networks. It can reveal hidden layers of information about the higher-order structures formed by non-pairwise interactions…

Combinatorics · Mathematics 2025-06-25 Udit Raj , Slobodan Maletić , Sudeepto Bhattacharya

Topological data analysis uses tools from topology -- the mathematical area that studies shapes -- to create representations of data. In particular, in persistent homology, one studies one-parameter families of spaces associated with data,…

Machine Learning · Computer Science 2020-12-01 Guido Montúfar , Nina Otter , Yuguang Wang

Persistent homology has recently emerged as a powerful technique in topological data analysis for analyzing the emergence and disappearance of topological features throughout a filtered space, shown via persistence diagrams. Additionally,…

Algebraic Topology · Mathematics 2016-12-16 Nicholas A. Scoville , Karthik Yegnesh

Persistent homology captures the evolution of topological features of a model as a parameter changes. The most commonly used summary statistics of persistent homology are the barcode and the persistence diagram. Another summary statistic,…

Methodology · Statistics 2016-04-01 Violeta Kovacev-Nikolic , Peter Bubenik , Dragan Nikolić , Giseon Heo

As complex networks find applications in a growing range of disciplines, the diversity of naturally occurring and model networks being studied is exploding. The adoption of a well-developed collection of network taxonomies is a natural…

Combinatorics · Mathematics 2016-01-25 Ann Sizemore , Chad Giusti , Danielle Bassett

Hyperuniform particle arrangements are characterized by a local number variance that grows more slowly than the volume of the observation window. We generalize this concept to describe particle systems in which particles carry weights:…

Statistical Mechanics · Physics 2026-03-04 Salvatore Torquato , Jaeuk Kim , Michael A. Klatt , Roberto Car , Paul J. Steinhardt

Protein-ligand binding is a fundamental biological process that is paramount to many other biological processes, such as signal transduction, metabolic pathways, enzyme construction, cell secretion, gene expression, etc. Accurate prediction…

Quantitative Methods · Quantitative Biology 2017-04-03 Zixuan Cang , Guo-Wei Wei

In topological data analysis, persistent homology is used to study the "shape of data". Persistent homology computations are completely characterized by a set of intervals called a bar code. It is often said that the long intervals…

Computational Geometry · Computer Science 2025-02-19 Peter Bubenik , Michael Hull , Dhruv Patel , Benjamin Whittle

Recent studies have actively employed persistent homology (PH), a topological data analysis technique, to analyze the topological information in time series data. Many successful studies have utilized graph representations of time series…

Algebraic Topology · Mathematics 2025-12-15 Eunwoo Heo , Jae-Hun Jung

Hyperuniformity, the suppression of density fluctuations at large length scales, is observed across a wide variety of domains, from cosmology to condensed matter and biological systems. Although the standard definition of hyperuniformity…

Statistical Mechanics · Physics 2024-05-07 Marco Salvalaglio , Dominic J. Skinner , Jörn Dunkel , Axel Voigt

Persistent homology (PH) is one of the most popular tools in topological data analysis (TDA), while graph theory has had a significant impact on data science. Our earlier work introduced the persistent spectral graph (PSG) theory as a…

Algebraic Topology · Mathematics 2020-12-22 Rui Wang , Rundong Zhao , Emily Ribando-Gros , Jiahui Chen , Yiying Tong , Guo-Wei Wei

The aim of this article is to describe a new perspective on functoriality of persistent homology and explain its intrinsic symmetry that is often overlooked. A data set for us is a finite collection of functions, called measurements, with a…

Algebraic Topology · Mathematics 2020-05-26 Wojciech Chacholski , Alessandro De Gregorio , Nicola Quercioli , Francesca Tombari

Determining whether two graphs are isomorphic is a fundamental problem with practical applications in areas such as molecular chemistry or social network analysis, yet it remains a challenging task, with exact solutions often being…

Persistent homology (PH) has been widely applied to graph data to extract topological features. However, little attention has been paid to how different distance functions on a graph affect the resulting persistence barcodes and their…

Algebraic Topology · Mathematics 2026-02-17 Eunwoo Heo , Byeongchan Choi , Jae-Hun Jung

In this paper we introduce a statistic, the persistent homology transform (PHT), to model surfaces in $\mathbb{R}^3$ and shapes in $\mathbb{R}^2$. This statistic is a collection of persistence diagrams - multiscale topological summaries…

Statistics Theory · Mathematics 2014-07-16 Katharine Turner , Sayan Mukherjee , Doug M Boyer

We use topological data analysis to study "functional networks" that we construct from time-series data from both experimental and synthetic sources. We use persistent homology with a weight rank clique filtration to gain insights into…

Quantitative Methods · Quantitative Biology 2017-05-24 Bernadette J. Stolz , Heather A. Harrington , Mason A. Porter