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As proteins with similar structures often have similar functions, analysis of protein structures can help predict protein functions and is thus important. We consider the problem of protein structure classification, which computationally…

Machine Learning · Statistics 2019-10-08 Hongyu Guo , Khalique Newaz , Scott Emrich , Tijana Milenkovic , Jun Li

By general case we mean methods able to process simplicial sets and chain complexes not of finite type. A filtration of the object to be studied is the heart of both subjects persistent homology and spectral sequences. In this paper we…

Computational Geometry · Computer Science 2014-04-01 Ana Romero , Jónathan Heras , Julio Rubio , Francis Sergeraert

We use persistent homology along with the eigenfunctions of the Laplacian to study similarity amongst triangulated 2-manifolds. Our method relies on studying the lower-star filtration induced by the eigenfunctions of the Laplacian. This…

Machine Learning · Statistics 2019-04-25 Yunhao Zhang , Haowen Liu , Paul Rosen , Mustafa Hajij

Hypergraphs and simplical complexes both capture the higher-order interactions of complex systems, ranging from higher-order collaboration networks to brain networks. One open problem in the field is what should drive the choice of the…

Physics and Society · Physics 2022-09-28 Federica Baccini , Filippo Geraci , Ginestra Bianconi

We propose a study of multipartite entanglement through persistent homology, a tool used in topological data analysis. In persistent homology, a 1-parameter filtration of simplicial complexes called persistence complex is used to reveal…

Quantum Physics · Physics 2024-06-05 Gregory A. Hamilton , Felix Leditzky

Recently, multi-scale notions of local homology (a variant of persistent homology) have been used to study the local structure of spaces around a given point from a point cloud sample. Current reconstruction guarantees rely on constructing…

Computational Geometry · Computer Science 2013-04-24 Primoz Skraba , Bei Wang

We show that recent results on randomized dimension reduction schemes that exploit structural properties of data can be applied in the context of persistent homology. In the spirit of compressed sensing, the dimension reduction is…

Computational Geometry · Computer Science 2019-09-09 Martin Lotz

Latent space matching, which consists of matching distributions of features in latent space, is a crucial component for tasks such as adversarial attacks and defenses, domain adaptation, and generative modelling. Metrics for probability…

Machine Learning · Computer Science 2025-03-05 Hiu-Tung Wong , Darrick Lee , Hong Yan

Inspired by topological data analysis techniques, we introduce persistent homology observables and apply them in a geometric analysis of the dynamics of quantum field theories. As a prototype application, we consider data from a…

Quantum Gases · Physics 2021-09-23 Daniel Spitz , Jürgen Berges , Markus K. Oberthaler , Anna Wienhard

Persistent homology is a popular technique in topological data analysis that tracks the lifespans of homological features in a nested sequence of spaces. This data is typically presented in a multi-set called a persistence diagram or a…

Algebraic Topology · Mathematics 2025-11-26 Deni Salja

The protein folding problem must ultimately be solved on all length scales from the atomic up through a hierarchy of complicated structures. By analyzing the stability of the folding process using physics and mathematics, this paper shows…

Biological Physics · Physics 2015-05-28 Walter Simmons , Joel L. Weiner

Spatial transcriptomics (ST) measures gene expression at a set of spatial locations in a tissue. Communities of nearby cells that express similar genes form \textit{spatial domains}. Specialized ST clustering algorithms have been developed…

Quantitative Methods · Quantitative Biology 2025-11-12 Perry Beamer , Zixuan Cang

In graph representation learning, it is important that the complex geometric structure of the input graph, e.g. hidden relations among nodes, is well captured in embedding space. However, standard Euclidean embedding spaces have a limited…

Machine Learning · Computer Science 2023-07-11 Tuc Nguyen-Van , Dung D. Le , The-Anh Ta

Persistent homology is a natural tool for probing the topological characteristics of weighted graphs, essentially focusing on their $0$-dimensional homology. While this area has been substantially studied, we present a new approach to…

Algebraic Topology · Mathematics 2023-10-03 Omer Bobrowski , Primoz Skraba

We develop a method for analyzing spatial and spatiotemporal anomalies in geospatial data using topological data analysis (TDA). To do this, we use persistent homology (PH), which allows one to algorithmically detect geometric voids in a…

Physics and Society · Physics 2022-03-01 Abigail Hickok , Deanna Needell , Mason A. Porter

Appropriately representing elements in a database so that queries may be accurately matched is a central task in information retrieval; recently, this has been achieved by embedding the graphical structure of the database into a manifold in…

Machine Learning · Statistics 2023-07-10 Yueqi Cao , Athanasios Vlontzos , Luca Schmidtke , Bernhard Kainz , Anthea Monod

Single-parameter persistent homology, a key tool in topological data analysis, has been widely applied to data problems along with statistical techniques that quantify the significance of the results. In contrast, statistical techniques for…

Algebraic Topology · Mathematics 2020-12-14 Matthew Wright , Xiaojun Zheng

Recent years have seen substantial advances in the development of biofunctional materials using synthetic polymers. The growing problem of elusive sequence-functionality relations for most biomaterials has driven researchers to seek more…

Quantitative Methods · Quantitative Biology 2022-07-06 Yun Zhou , Boying Gong , Tao Jiang , Ting Xu , Haiyan Huang

One-dimensional persistent homology is arguably the most important and heavily used computational tool in topological data analysis. Additional information can be extracted from datasets by studying multi-dimensional persistence modules and…

Algebraic Topology · Mathematics 2023-08-31 Facundo Mémoli , Anastasios Stefanou , Ling Zhou

The persistent homology transform (PHT) represents a shape with a multiset of persistence diagrams parameterized by the sphere of directions in the ambient space. In this work, we describe a finite set of diagrams that discretize the PHT…

Computational Geometry · Computer Science 2026-05-26 Brittany Terese Fasy , Samuel Micka , David L. Millman , Anna Schenfisch , Lucia Williams
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