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The CoHSI (Conservation of Hartley-Shannon Information) distribution is at the heart of a wide-class of discrete systems, defining the length distribution of their components amongst other global properties. Discrete systems such as the…

Other Quantitative Biology · Quantitative Biology 2018-06-26 Les Hatton , Gregory Warr

We begin with the extraordinary observation that the length distribution of 80 million proteins in UniProt, the Universal Protein Resource, measured in amino acids, is qualitatively identical to the length distribution of large collections…

Other Quantitative Biology · Quantitative Biology 2017-09-13 Les Hatton , Gregory Warr

The Conservation of Energy plays a pivotal part in the development of the physical sciences. With the growth of computation and the study of other discrete token based systems such as the genome, it is useful to ask if there are…

Information Theory · Computer Science 2012-09-25 Les Hatton

The CoHSI (Conservation of Hartley-Shannon Information) distribution is at the heart of a wide-class of discrete systems, defining (amongst other properties) the length distribution of their components. Discrete systems such as the known…

Other Quantitative Biology · Quantitative Biology 2018-07-31 Les Hatton , Gregory Warr

The length distribution of proteins measured in amino acids follows the CoHSI (Conservation of Hartley-Shannon Information) probability distribution. In previous papers we have verified various predictions of this using the Uniprot database…

Other Quantitative Biology · Quantitative Biology 2018-10-23 Les Hatton , Gregory Warr

In previous papers we have described with strong experimental support, the organising role that CoHSI (Conservation of Hartley-Shannon Information) plays in determining important global properties of all known proteins, from defining the…

Other Quantitative Biology · Quantitative Biology 2018-11-07 Les Hatton , Gregory Warr

n-tuple power law widely exists in language, computer program code, DNA and music. After a vast amount of Zipf analyses of n-tuple power law from empirical data, we propose a model to explain the n-tuple power law feature existed in these…

Data Analysis, Statistics and Probability · Physics 2009-08-05 Xiaocong Gan , Dahui Wang , Zhangang Han

In a matching paper (arXiv:1207.5027), I proved that Conservation of Size and Information in a discrete token based system is overwhelmingly likely to lead to a power-law component size distribution with respect to the size of its unique…

Information Theory · Computer Science 2012-09-11 Les Hatton

The behavior and architecture of large scale discrete state systems found in computer software and hardware can be specified and analyzed using a particular class of primitive recursive functions. This paper begins with an illustration of…

Formal Languages and Automata Theory · Computer Science 2025-11-04 Victor Yodaiken

Shannon information has, in the past, been applied to quantify the genetic diversity of many natural populations. Here, we apply the Shannon concept to consecutive generations of alleles as they evolve over time. We suppose a genetic system…

Populations and Evolution · Quantitative Biology 2015-12-17 J. S. Glasenapp , B. R. Frieden , C. D. Cruz

Recent in vitro data show that neurons respond to input variance with varying sensitivities. Here, we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes, one that is more sensitive to input variance…

Neurons and Cognition · Quantitative Biology 2007-07-17 Brian Nils Lundstrom , Sungho Hong , Matthew H. Higgs , Adrienne L. Fairhall

Natural supersymmetry with light higgsinos is most likely to emerge from the string landscape since the volume of scan parameter space shrinks to tiny volumes for electroweak unnatural models. Rather general arguments favor a landscape…

High Energy Physics - Phenomenology · Physics 2024-08-06 Howard Baer , Vernon Barger , Kairui Zhang

We present and rigorously analyze the behavior of a distributed, stochastic algorithm for separation and integration in self-organizing particle systems, an abstraction of programmable matter. Such systems are composed of individual…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-06-06 Sarah Cannon , Joshua J. Daymude , Cem Gokmen , Dana Randall , Andréa W. Richa

We introduce a new family of quantum circuits in Continuous Variables and we show that, relying on the widely accepted conjecture that the polynomial hierarchy of complexity classes does not collapse, their output probability distribution…

Quantum Physics · Physics 2017-12-13 Ulysse Chabaud , Tom Douce , Damian Markham , Peter van Loock , Elham Kashefi , Giulia Ferrini

Given a small random sample of $n$-bit strings labeled by an unknown Boolean function, which properties of this function can be tested computationally efficiently? We show an equivalence between properties that are efficiently testable from…

Computational Complexity · Computer Science 2026-04-07 Cynthia Dwork , Pranay Tankala

Nonlinear system identification often involves a fundamental trade-off between interpretability and flexibility, often requiring the incorporation of physical constraints. We propose a unified data-driven framework that combines the…

Machine Learning · Computer Science 2025-09-16 Federico J. Gonzalez , Luis P. Lara

Predictive coding has emerged as an influential normative model of neural computation, with numerous extensions and applications. As such, much effort has been put into mapping PC faithfully onto the cortex, but there are issues that remain…

Neurons and Cognition · Quantitative Biology 2023-03-07 Siavash Golkar , Tiberiu Tesileanu , Yanis Bahroun , Anirvan M. Sengupta , Dmitri B. Chklovskii

Integrative learning of multiple datasets has the potential to mitigate the challenge of small $n$ and large $p$ that is often encountered in analysis of big biomedical data such as genomics data. Detection of weak yet important signals can…

Methodology · Statistics 2022-07-04 Changgee Chang , Zongyu Dai , Jihwan Oh , Qi Long

We introduce the notion of a template for discrete Morse theory. Templates provide a memory efficient approach to the computation of homological invariants (e.g., homology, persistent homology, Conley complexes) of cell complexes. We…

Algebraic Topology · Mathematics 2021-06-30 Shaun Harker , Konstantin Mischaikow , Kelly Spendlove

Shannon information (SI) and its special case, divergence, are defined for a DNA sequence in terms of probabilities of chemical words in the sequence and are computed for a set of complete genomes highly diverse in length and composition.…

Genomics · Quantitative Biology 2009-11-10 Hong-Da Chen , Chang-Heng Chang , Li-Ching Hsieh , Hoong-Chien Lee
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