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This work aims at improving the quality of structural variant prediction from the mapped reads of a sequenced genome. We suggest a new model based on cluster editing in weighted graphs and introduce a new heuristic algorithm that allows to…

Data Structures and Algorithms · Computer Science 2013-10-15 Thomas Bellitto , Tobias Marschall , Alexander Schönhuth , Gunnar W. Klau

Continuous-time series is essential for different modern application areas, e.g. healthcare, automobile, energy, finance, Internet of things (IoT) and other related areas. Different application needs to process as well as analyse a massive…

Machine Learning · Computer Science 2024-09-17 Mansura Habiba , Barak A. Pearlmutter , Mehrdad Maleki

Features play a crucial role in computer vision. Initially designed to detect salient elements by means of handcrafted algorithms, features are now often learned by different layers in Convolutional Neural Networks (CNNs). This paper…

Computer Vision and Pattern Recognition · Computer Science 2021-11-18 Loris Nanni , Stefano Ghidoni , Sheryl Brahnam

Survival analysis consists of studying the elapsed time until an event of interest, such as the death or recovery of a patient in medical studies. This work explores the potential of neural networks in survival analysis from clinical and…

Statistics Theory · Mathematics 2021-05-19 Mathilde Sautreuil , Sarah Lemler , Paul-Henry Cournède

Convolutional Neural Networks (CNNs) have gained a significant attraction in the recent years due to their increasing real-world applications. Their performance is highly dependent to the network structure and the selected optimization…

Neural and Evolutionary Computing · Computer Science 2019-10-01 Parsa Esfahanian , Mohammad Akhavan

This paper focuses on the analysis of the application effectiveness of the integration of deep learning and computer vision technologies. Deep learning achieves a historic breakthrough by constructing hierarchical neural networks, enabling…

Computer Vision and Pattern Recognition · Computer Science 2023-12-21 Bo Liu , Liqiang Yu , Chang Che , Qunwei Lin , Hao Hu , Xinyu Zhao

The ability to predict the evolution of a pathogen would significantly improve the ability to control, prevent, and treat disease. Despite significant progress in other problem spaces, deep learning has yet to contribute to the issue of…

Quantitative Methods · Quantitative Biology 2020-08-28 Daniel S. Berman , Craig Howser , Thomas Mehoke , Jared D. Evans

Next-generation sequencing (NGS) is a pivotal technique in genome sequencing due to its high throughput, rapid results, cost-effectiveness, and enhanced accuracy. Its significance extends across various domains, playing a crucial role in…

Genomics · Quantitative Biology 2025-04-28 Fathima Nuzla Ismail , Shanika Amarasoma

Artificial neural networks have recently shown great results in many disciplines and a variety of applications, including natural language understanding, speech processing, games and image data generation. One particular application in…

Computer Vision and Pattern Recognition · Computer Science 2018-03-07 Felix Altenberger , Claus Lenz

Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical…

Machine Learning · Computer Science 2025-09-08 Matouš Soldát , Jiří Kléma

Diffusion Models represent a significant advancement in generative modeling, employing a dual-phase process that first degrades domain-specific information via Gaussian noise and restores it through a trainable model. This framework enables…

Neural and Evolutionary Computing · Computer Science 2024-11-21 Benedikt Hartl , Yanbo Zhang , Hananel Hazan , Michael Levin

Computational analysis methods including machine learning have a significant impact in the fields of genomics and medicine. High-throughput gene expression analysis methods such as microarray technology and RNA sequencing produce enormous…

Genomics · Quantitative Biology 2022-09-28 Nikita Bhandari , Rahee Walambe , Ketan Kotecha , Satyajeet Khare

Next Generation Sequencing can sample the whole genome (WGS) or the 1-2% of the genome that codes for proteins called the whole exome (WES). Machine learning approaches to variant calling achieve high accuracy in WGS data, but the reduced…

Genomics · Quantitative Biology 2019-11-19 Ren Yi , Pi-Chuan Chang , Gunjan Baid , Andrew Carroll

As sequencing technologies become more affordable and genomic databases expand continuously, the reuse of publicly available sequencing data emerges as a powerful strategy for studying microbial pathogens. Indeed, raw sequencing reads…

Quantitative Methods · Quantitative Biology 2025-05-16 Damien Richard , Nils Poulicard

Natural Language Processing (NLP) helps empower intelligent machines by enhancing a better understanding of the human language for linguistic-based human-computer communication. Recent developments in computational power and the advent of…

Computation and Language · Computer Science 2021-03-02 Amirsina Torfi , Rouzbeh A. Shirvani , Yaser Keneshloo , Nader Tavaf , Edward A. Fox

Smart Manufacturing refers to optimization techniques that are implemented in production operations by utilizing advanced analytics approaches. With the widespread increase in deploying Industrial Internet of Things (IIoT) sensors in…

Machine Learning · Computer Science 2020-09-01 Mohammadhossein Ghahramani , Yan Qiao , MengChu Zhou , Adrian OHagan , James Sweeney

In the last few years, quantum computing and machine learning fostered rapid developments in their respective areas of application, introducing new perspectives on how information processing systems can be realized and programmed. The…

The growing complexity of machinery and the increasing demand for operational efficiency and safety have driven the development of advanced fault diagnosis techniques. Among these, convolutional neural networks (CNNs) have emerged as a…

Gene selection plays a pivotal role in oncology research for improving outcome prediction accuracy and facilitating cost-effective genomic profiling for cancer patients. This paper introduces two gene selection strategies for deep…

Genomics · Quantitative Biology 2024-03-05 Akhila Krishna , Ravi Kant Gupta , Pranav Jeevan , Amit Sethi

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang