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Variability in staining protocols, such as different slide preparation techniques, chemicals, and scanner configurations, can result in a diverse set of whole slide images (WSIs). This distribution shift can negatively impact the…

Image and Video Processing · Electrical Eng. & Systems 2023-04-25 Kudaibergen Abutalip , Numan Saeed , Mustaqeem Khan , Abdulmotaleb El Saddik

Stain variation is a unique challenge associated with automated analysis of digital pathology. Numerous methods have been developed to improve the robustness of machine learning methods to stain variation, but comparative studies have…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Michael Yeung , Todd Watts , Sean YW Tan , Pedro F. Ferreira , Andrew D. Scott , Sonia Nielles-Vallespin , Guang Yang

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Siyu , Lin , Haowen Zhou , Richard J. Cote , Mark Watson , Ramaswamy Govindan , Changhuei Yang

Computer assisted diagnosis in digital pathology is becoming ubiquitous as it can provide more efficient and objective healthcare diagnostics. Recent advances have shown that the convolutional Neural Network (CNN) architectures, a…

Image and Video Processing · Electrical Eng. & Systems 2022-01-05 Sruthi Krishna , Suganthi S. S , Shivsubramani Krishnamoorthy , Arnav Bhavsar

In digital pathology, different staining procedures and scanners cause substantial color variations in whole-slide images (WSIs), especially across different laboratories. These color shifts result in a poor generalization of deep…

Image and Video Processing · Electrical Eng. & Systems 2021-07-27 Sophia J. Wagner , Nadieh Khalili , Raghav Sharma , Melanie Boxberg , Carsten Marr , Walter de Back , Tingying Peng

Stain variations often decrease the generalization ability of deep learning based approaches in digital histopathology analysis. Two separate proposals, namely stain normalization (SN) and stain augmentation (SA), have been spotlighted to…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Yiqing Shen , Yulin Luo , Dinggang Shen , Jing Ke

Convolutional neural networks (CNNs) have demonstrated remarkable success in vision-related tasks. However, their susceptibility to failing when inputs deviate from the training distribution is well-documented. Recent studies suggest that…

Computer Vision and Pattern Recognition · Computer Science 2023-07-14 Pradyumna Elavarthi , James Lee , Anca Ralescu

Stain color variation in histological images, caused by a variety of factors, is a challenge not only for the visual diagnosis of pathologists but also for cell segmentation algorithms. To eliminate the color variation, many stain…

Image and Video Processing · Electrical Eng. & Systems 2022-10-27 Huaqian Wu , Nicolas Souedet , Camille Mabillon , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

Performance of deep learning algorithms decreases drastically if the data distributions of the training and testing sets are different. Due to variations in staining protocols, reagent brands, and habits of technicians, color variation in…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Abhijeet Patil , Mohd. Talha , Aniket Bhatia , Nikhil Cherian Kurian , Sammed Mangale , Sunil Patel , Amit Sethi

We introduce style augmentation, a new form of data augmentation based on random style transfer, for improving the robustness of convolutional neural networks (CNN) over both classification and regression based tasks. During training, our…

Computer Vision and Pattern Recognition · Computer Science 2019-04-15 Philip T. Jackson , Amir Atapour-Abarghouei , Stephen Bonner , Toby Breckon , Boguslaw Obara

Computational pathology is a domain that aims to develop algorithms to automatically analyze large digitized histopathology images, called whole slide images (WSI). WSIs are produced scanning thin tissue samples that are stained to make…

Image and Video Processing · Electrical Eng. & Systems 2022-01-20 Niccoló Marini , Manfredo Atzori , Sebastian Otálora , Stephane Marchand-Maillet , Henning Müller

Normalizing unwanted color variations due to differences in staining processes and scanner responses has been shown to aid machine learning in computational pathology. Of the several popular techniques for color normalization, structure…

Computer Vision and Pattern Recognition · Computer Science 2019-01-11 Goutham Ramakrishnan , Deepak Anand , Amit Sethi

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

Convolutional Neural Networks (CNNs) serve as the workhorse of deep learning, finding applications in various fields that rely on images. Given sufficient data, they exhibit the capacity to learn a wide range of concepts across diverse…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Saorj Kumar , Prince Asiamah , Oluwatoyin Jolaoso , Ugochukwu Esiowu

Convolutional Neural Networks (CNNs) show impressive performance in the standard classification setting where training and testing data are drawn i.i.d. from a given domain. However, CNNs do not readily generalize to new domains with…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Nathan Somavarapu , Chih-Yao Ma , Zsolt Kira

Image colorization achieves more and more realistic results with the increasing computation power of recent deep learning techniques. It becomes more difficult to identify the fake colorized images by human eyes. In this work, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Weize Quan , Dong-Ming Yan , Kai Wang , Xiaopeng Zhang , Denis Pellerin

Deep learning is popularly used for analyzing pathology images, but variations in image properties can limit the effectiveness of the models. The study aims to develop a method that transfers the variability present in the training set to…

Image and Video Processing · Electrical Eng. & Systems 2024-09-12 M. Muneeb Arshad , Hasan Sajid , M. Jawad Khan

In this paper, we develop a complete pipeline for stain normalization, segmentation, and classification of nuclei in hematoxylin and eosin (H&E) stained breast cancer histopathology images. In the first step, we use a CNN-based stain…

Computer Vision and Pattern Recognition · Computer Science 2018-11-12 Edwin Yuan , Junkyo Suh

Convolutional Neural Networks (CNN) offer state of the art performance in various computer vision tasks. Many of those tasks require different subtypes of affine invariances (scale, rotational, translational) to image transformations.…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Facundo Manuel Quiroga , Franco Ronchetti , Laura Lanzarini , Aurelio Fernandez-Bariviera
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