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Enabling clinicians and researchers to directly interact with global genomic data resources by removing technological barriers is vital for medical genomics. AskBeacon enables Large Language Models to be applied to securely shared cohorts…

Background: Open innovation highlights the potential benefits of external collaboration and knowledge-sharing, often exemplified through Open Source Software (OSS). The public sector has thus far mainly focused on the sharing of Open…

Software Engineering · Computer Science 2022-08-04 Johan Linåker , Per Runeson

Co-speech gestures, gestures that accompany speech, play an important role in human communication. Automatic co-speech gesture generation is thus a key enabling technology for embodied conversational agents (ECAs), since humans expect ECAs…

Human-Computer Interaction · Computer Science 2021-02-24 Taras Kucherenko , Patrik Jonell , Youngwoo Yoon , Pieter Wolfert , Gustav Eje Henter

Gene expression analysis holds the key to many biomedical discoveries, yet extracting insights from raw transcriptomic data remains formidable due to the complexity of multiple large, semi-structured files and the need for extensive domain…

Artificial Intelligence · Computer Science 2026-05-19 Haoyang Liu , Yijiang Li , Haohan Wang

Across the life sciences, an ongoing effort over the last 50 years has made data and methods more reproducible and transparent. This openness has led to transformative insights and vastly accelerated scientific progress. For example,…

Neurons and Cognition · Quantitative Biology 2026-02-25 Colleen J. Gillon , Cody Baker , Ryan Ly , Edoardo Balzani , Bingni W. Brunton , Manuel Schottdorf , Satrajit Ghosh , Nima Dehghani

The transition to Open Science necessitates robust and reliable metadata. While national initiatives, such as the French Open Science Monitor, aim to track this evolution using open data, reliance on proprietary databases persists in many…

Digital Libraries · Computer Science 2025-06-18 Eric Jeangirard

The parallel and distributed processing are becoming de facto industry standard, and a large part of the current research is targeted on how to make computing scalable and distributed, dynamically, without allocating the resources on…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-04-10 Rajendra Purohit , K R Chowdhary , S D Purohit

Open Source Software (OSS) is forming the spines of technology infrastructures, attracting millions of talents to contribute. Notably, it is challenging and critical to consider both the developers' interests and the semantic features of…

Software Engineering · Computer Science 2023-04-26 Yiqiao Jin , Yunsheng Bai , Yanqiao Zhu , Yizhou Sun , Wei Wang

The use of deep learning models in computational biology has increased massively in recent years, and it is expected to continue with the current advances in the fields such as Natural Language Processing. These models, although able to…

Software practitioners are discussing GenAI transformations in software project management openly and widely. To understand the state of affairs, we performed a grey literature review using 47 publicly available practitioner sources…

Software Engineering · Computer Science 2026-01-26 Lakshana Iruni Assalaarachchi , Zainab Masood , Rashina Hoda , John Grundy

Genome sequence analysis plays a pivotal role in enabling many medical and scientific advancements in personalized medicine, outbreak tracing, and forensics. However, the analysis of genome sequencing data is currently bottlenecked by the…

Hardware Architecture · Computer Science 2021-11-04 Damla Senol Cali

Atomic-level simulations are widely used to study biomolecules and their dynamics. A common goal in such studies is to compare simulations of a molecular system under several conditions -- for example, with various mutations or bound…

Biomolecules · Quantitative Biology 2025-01-07 Martin Vögele , Neil J. Thomson , Sang T. Truong , Jasper McAvity , Ulrich Zachariae , Ron O. Dror

Open data refers to data that is freely available for reuse. Although there has been rapid increase in availability of open data to public in the last decade, this has not translated into better decision-support tools for them. We propose…

Artificial Intelligence · Computer Science 2019-01-14 Biplav Srivastava

The emergence of "big data" offers unprecedented opportunities for not only accelerating scientific advances but also enabling new modes of discovery. Scientific progress in many disciplines is increasingly enabled by our ability to examine…

Computers and Society · Computer Science 2017-07-03 Vasant G. Honavar , Mark D. Hill , Katherine Yelick

Sociotechnical research increasingly includes the social sub-networks that emerge from large-scale sociotechnical infrastructure, including the infrastructure for building open source software. This paper addresses these numerous…

Computers and Society · Computer Science 2024-03-14 Sean P. Goggins , Kevin Lumbard , Matt Germonprez , Caifan Du , Karthik Ram , James Howison

In the era of data-driven science, conducting computational experiments that involve analysing large datasets using heterogeneous computational clusters, is part of the everyday routine for many scientists. Moreover, to ensure the…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-03-23 Thanasis Vergoulis , Konstantinos Zagganas , Loukas Kavouras , Martin Reczko , Stelios Sartzetakis , Theodore Dalamagas

A computationally simple genome-wide association study (GWAS) algorithm for estimating the main and epistatic effects of markers or single nucleotide polymorphisms (SNPs) is proposed. It is based on the intuitive assumption that changes of…

Quantitative Methods · Quantitative Biology 2017-08-08 Lev V. Utkin , Irina L. Utkina

Objective: Our objective is to explore how public entities in the role of platform providers can address this issue by enabling collaboration within their OGD ecosystems, both in terms of the OGD published on the underpinning platform, as…

Software Engineering · Computer Science 2022-08-02 Johan Linåker , Per Runeson

Benchmarking involves designing, running and disseminating rigorous performance assessments of methods, most often for data analysis and software tools, but the process can also be applied to experimental systems. Ideally, a benchmarking…

Other Quantitative Biology · Quantitative Biology 2026-02-12 Izaskun Mallona , Almut Luetge , Ben Carrillo , Daniel Incicau , Reto Gerber , Aidan Meara , Anthony Sonrel , Charlotte Soneson , Mark D. Robinson

Background: Data mining and analyzing of public Git software repositories is a growing research field. The tools used for studies that investigate a single project or a group of projects have been refined, but it is not clear whether the…

Software Engineering · Computer Science 2020-08-18 Adam Tutko , Austin Henley , Audris Mockus
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