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The movement of molecules inside living cells is a fundamental feature of biological processes. The ability to both observe and analyse the details of molecular diffusion in vivo at the single molecule and single cell level can add…

Quantitative Methods · Quantitative Biology 2012-11-21 Alex Robson , Kevin Burrage , Mark Leake

Morphological transitions of phase separation associated with the asymmetry of lipid composition were investigated using micrometer-sized vesicles of lipid bilayers made from a lipid mixture. The complete macro-phase-separated morphology…

Biological Physics · Physics 2015-04-14 Shunsuke F. Shimobayashi , Masatoshi Ichikawa , Takashi Taniguchi

We study a phenomenological electropermeabilization model in a periodic medium representing biological tissue. Starting from a cell-level model describing the electric potential and the degree of porosity, we perform dimension analysis to…

Analysis of PDEs · Mathematics 2026-02-03 Tobias Gebäck , Ioanna Motschan-Armen , Irina Pettersson

In a recent paper [1] we developed a theoretical model to describe current transients arising during electrochemical deposition experiments performed at the bottom of sub-micrometric cylindrical vessels with permeable walls. In the present…

Chemical Physics · Physics 2011-12-09 P. C. T. DÁjello , M. L. Sartorelli , L. Lauck

A theory of a lateral stress relaxation in a fluid bilayer membrane under a step-like pressure pulse is proposed. It is shown theoretically that transfer of lipid molecules into a strained region may lead to a substantial decrease of the…

Soft Condensed Matter · Physics 2007-05-23 S. I. Mukhin , S. V. Baoukina

Mathematically modeling complex transport phenomena at the molecular level can be a powerful tool for identifying transport mechanisms and predicting macroscopic properties. We use two different stochastic time series models, parameterized…

Soft Condensed Matter · Physics 2020-09-11 Benjamin J. Coscia , Michael R. Shirts

The design of biologically-inspired wireless communication systems using bacteria as the basic element of the system is initially motivated by a phenomenon called \emph{Quorum Sensing}. Due to high randomness in the individual behavior of a…

Information Theory · Computer Science 2016-11-17 Arash Einolghozati , Mohsen Sardari , Faramarz Fekri

The assembly of proteins in membranes plays a key role in many crucial cellular pathways. Despite their importance, characterizing transmembrane assembly remains challenging for experiments and simulations. Equilibrium molecular dynamics…

Soft Condensed Matter · Physics 2024-08-05 Emil Jackel , Gianmarco Lazzeri , Roberto Covino

Throughout our history, we, humans, have sought to better control and understand our environment. To this end, we have extended our natural senses with a host of sensors-tools that enable us to detect both the very large, such as the…

Biological Physics · Physics 2023-06-09 Kherim Willems

The spontaneous migration of droplets on conical fibers is studied experimentally by depositing silicone oil droplets onto conical glass fibers. Their motion is recorded using optical microscopy and analysed to extract the relevant…

Soft Condensed Matter · Physics 2020-09-01 Clementine Fournier , Carmen Lee , Rafael Schulman , Elie Raphael , Kari Dalnoki-Veress

In this paper we consider the diffusion of nanoparticles taken up by a semi-permeable spherical cell placed in the path of a diffusive particle field generated by an external planar source. The cell interior and exterior are characterized…

Biological Physics · Physics 2024-06-11 Stanley J. Miklavcic

We study material transport and permeation through a lamellar stack of multi-component lipid membranes by performing Monte Carlo simulations of a stacked two-dimensional Ising model in presence of permeants. In the model, permeants are…

Soft Condensed Matter · Physics 2017-12-29 Takuma Hoshino , Shigeyuki Komura , David Andelman

Diffusion probabilistic models have made their way into a number of high-profile applications since their inception. In particular, there has been a wave of research into using diffusion models in the prediction and design of biomolecular…

Biomolecules · Quantitative Biology 2024-06-05 Trevor Norton , Debswapna Bhattacharya

Giant unilamellar vesicles (GUVs) composed of as few as three lipid species can phase separate into small-scale lipid domains with stripes and dots patterns. These patterns have been experimentally characterized in terms of how their size…

Soft Condensed Matter · Physics 2025-05-21 Qiwei Yu , Andrej Košmrlj

Movements of molecular motors on cytoskeletal filaments are described by directed walks on a line. Detachment from this line is allowed to occur with a small probability. Motion in the surrounding fluid is described by symmetric random…

Statistical Mechanics · Physics 2007-05-23 Theo M. Nieuwenhuizen , Stefan Klumpp , Reinhard Lipowsky

Single-file diffusion is a ubiquitous physical process exploited by living and synthetic systems to exchange molecules with their environment. It is paramount quantifying the escape time needed for single files of particles to exit from…

Soft Condensed Matter · Physics 2016-07-25 Emanuele Locatelli , Matteo Pierno , Fulvio Baldovin , Enzo Orlandini , Yizhou Tan , Stefano Pagliara

Current fluctuations in pure lipid membranes have been shown to occur under the influence of transmembrane electric fields (electroporation) as well as a result from structural rearrangements of the lipid bilayer during phase transition…

Biological Physics · Physics 2015-05-13 B. Wunderlich , C . Leirer , A-L. Idzko , U. F. Keyser , A. Wixforth , V. M. Myles , T. Heimburg , M. F. Schneider

We report diffusion coeffcients of micron-scale liquid domains in giant unilamellar vesicles of phospholipids and cholesterol. The trajectory of each domain is tracked, and the mean square displacement grows linearly in time as expected for…

Soft Condensed Matter · Physics 2007-05-23 Pietro Cicuta , Sarah L. Keller , Sarah L. Veatch

This paper studies the mechanisms of dispersion in the laminar flow through the pore space of a $3$-dimensional porous medium. We focus on pre-asymptotic transport prior to the asymptotic hydrodynamic dispersion regime, in which solute…

Fluid Dynamics · Physics 2018-03-05 Marco Dentz , Matteo Icardi , Juan J. Hidalgo

We study the translocation of a flexible polymer through extended patterned pores using molecular dynamics (MD) simulations. We consider cylindrical and conical pore geometries that can be controlled by the angle of the pore apex $\alpha$.…

Soft Condensed Matter · Physics 2026-02-11 Andri Sharma , Abhishek Chaudhuri , Rajeev Kapri