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We present the first theoretical convergence analysis of machine learning training under fully homomorphic encryption (FHE), combined with a differentially private (DP) training algorithm tailored to encrypted computation. Our approach…

Machine Learning · Computer Science 2026-05-28 Yvonne Zhou , Mingyu Liang , Ivan Brugere , Danial Dervovic , Yue Guo , Antigoni Polychroniadou , Min Wu , Dana Dachman-Soled

Fully Homomorphic Encryption (FHE) enables the processing of encrypted data without decrypting it. FHE has garnered significant attention over the past decade as it supports secure outsourcing of data processing to remote cloud services.…

Graph Convolutional Neural Networks (GCNs) have gained widespread popularity in various fields like personal healthcare and financial systems, due to their remarkable performance. Despite the growing demand for cloud-based GCN services,…

Cryptography and Security · Computer Science 2025-06-13 Zhaoxuan Kan , Husheng Han , Shangyi Shi , Tenghui Hua , Hang Lu , Xiaowei Li , Jianan Mu , Xing Hu

The problems of large-scale multiple testing are often encountered in modern scientific researches. Conventional multiple testing procedures usually suffer considerable loss of testing efficiency due to the lack of consideration of…

Methodology · Statistics 2022-12-21 Pengfei Wang , Zhaofeng Tian

Homomorphic Encryption (HE) enables users to securely outsource both the storage and computation of sensitive data to untrusted servers. Not only does HE offer an attractive solution for security in cloud systems, but lattice-based HE…

Cryptography and Security · Computer Science 2022-09-07 Kaustubh Shivdikar , Gilbert Jonatan , Evelio Mora , Neal Livesay , Rashmi Agrawal , Ajay Joshi , Jose Abellan , John Kim , David Kaeli

With the increasing affordability and availability of patient data, hospitals tend to outsource their data to cloud service providers (CSPs) for the purpose of storage and analytics. However, the concern of data privacy significantly limits…

Cryptography and Security · Computer Science 2021-08-31 Xiaojie Zhu , Erman Ayday , Roman Vitenberg

Polygenic risk scores (PRSs) aggregate genetic effect estimates to predict disease susceptibility, yet clinical deployment often exposes raw genotype data to third-party compute infrastructure. Prior homomorphic-encryption approaches, still…

Genomics · Quantitative Biology 2026-05-22 Kimon Antonios Provatas , Christos Galanopoulos , Ilias Georgakopoulos-Soares

Fully homomorphic encryption (FHE) enables private inference by evaluating neural networks on encrypted data. In this way, we can delegate the computation to a third party server without ever revealing the user's data. Currently, the CKKS…

Cryptography and Security · Computer Science 2026-05-25 Philipp Kern , Lorenzo Rovida , Samuel Teuber , Edoardo Manino , Carsten Sinz , Alberto Leporati

Large language models (LLMs) power modern AI applications, but processing sensitive data on untrusted servers raises privacy concerns. Homomorphic encryption (HE) enables computation on encrypted data for secure inference. However, neural…

Machine Learning · Computer Science 2025-11-19 Matan Avitan , Moran Baruch , Nir Drucker , Itamar Zimerman , Yoav Goldberg

Fully Homomorphic Encryption (FHE) is one of the most promising technologies for privacy protection as it allows an arbitrary number of function computations over encrypted data. However, the computational cost of these FHE systems limits…

Cryptography and Security · Computer Science 2020-05-06 Toufique Morshed , Md Momin Al Aziz , Noman Mohammed

Although genome-wide association studies (GWAS) have proven powerful for comprehending the genetic architecture of complex traits, they are challenged by a high dimension of single-nucleotide polymorphisms (SNPs) as predictors, the presence…

Applications · Statistics 2015-09-15 Jiahan Li , Zhong Wang , Runze Li , Rongling Wu

Genome-wide association studies (GWA studies or GWAS) investigate the relationships between genetic variants such as single-nucleotide polymorphisms (SNPs) and individual traits. Recently, incorporating biological priors together with…

Machine Learning · Statistics 2017-09-13 Tao Yang , Paul Thompson , Sihai Zhao , Jieping Ye

Embeddings, which compress information in raw text into semantics-preserving low-dimensional vectors, have been widely adopted for their efficacy. However, recent research has shown that embeddings can potentially leak private information…

Computation and Language · Computer Science 2022-10-07 Garam Lee , Minsoo Kim , Jai Hyun Park , Seung-won Hwang , Jung Hee Cheon

Logistic Regression (LR) is the most widely used machine learning model in industry for its efficiency, robustness, and interpretability. Due to the problem of data isolation and the requirement of high model performance, many applications…

Cryptography and Security · Computer Science 2021-06-01 Chaochao Chen , Jun Zhou , Li Wang , Xibin Wu , Wenjing Fang , Jin Tan , Lei Wang , Alex X. Liu , Hao Wang , Cheng Hong

Fully Homomorphic Encryption (FHE) is a relatively recent advancement in the field of privacy-preserving technologies. FHE allows for the arbitrary depth computation of both addition and multiplication, and thus the application of…

Machine Learning · Computer Science 2021-07-29 George Onoufriou , Paul Mayfield , Georgios Leontidis

With the rapid increase in cloud computing, concerns surrounding data privacy, security, and confidentiality also have been increased significantly. Not only cloud providers are susceptible to internal and external hacks, but also in some…

Cryptography and Security · Computer Science 2020-01-27 M. Sadegh Riazi , Kim Laine , Blake Pelton , Wei Dai

Preserving the privacy and security of big data in the context of cloud computing, while maintaining a certain level of efficiency of its processing remains to be a subject, open for improvement. One of the most popular applications…

Cryptography and Security · Computer Science 2022-02-02 Ş. S. Mağara , C. Yıldırım , F. Yaman , B. Dilekoğlu , F. R. Tutaş , E. Öztürk , K. Kaya , Ö. Taştan , E. Savaş

Recently Homomorphic Encryption (HE) is used to implement Privacy-Preserving Neural Networks (PPNNs) that perform inferences directly on encrypted data without decryption. Prior PPNNs adopt mobile network architectures such as SqueezeNet…

Cryptography and Security · Computer Science 2021-06-02 Qian Lou , Lei Jiang

Homomorphic Encryption (HE) is a cryptographic tool that allows performing computation under encryption, which is used by many privacy-preserving machine learning solutions, for example, to perform secure classification. Modern deep…

Cryptography and Security · Computer Science 2024-11-05 Nir Drucker , Itamar Zimerman

Privacy-preserving machine learning has become an important long-term pursuit in this era of artificial intelligence (AI). Fully Homomorphic Encryption (FHE) is a uniquely promising solution, offering provable privacy and security…

Cryptography and Security · Computer Science 2026-03-30 Cory Brynds , Parker McLeod , Lauren Caccamise , Asmita Pal , Dewan Saiham , Sazadur Rahman , Joshua San Miguel , Di Wu