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By dynamic planning, we refer to the ability of the human brain to infer and impose motor trajectories related to cognitive decisions. A recent paradigm, active inference, brings fundamental insights into the adaptation of biological…

Artificial Intelligence · Computer Science 2024-11-13 Matteo Priorelli , Ivilin Peev Stoianov

In this paper, we provide a theoretical framework that separates the control and learning tasks in a linear system. This separation allows us to combine offline model-based control with online learning approaches and thus circumvent current…

Optimization and Control · Mathematics 2024-03-26 Andreas A. Malikopoulos

To further advance our understanding of the brain, new concepts and theories are needed. In particular, the ability of the brain to create information flows must be reconciled with its propensity for synchronization and mass action. The…

Neurons and Cognition · Quantitative Biology 2014-07-04 Emmanuelle Tognoli , J. A. Scott Kelso

Improvements in technique in conjunction with an evolution of the theoretical and conceptual approach to neuronal networks provide a new perspective on living neurons in culture. Organization and connectivity are being measured…

Disordered Systems and Neural Networks · Physics 2010-08-02 Jean-Pierre Eckmann , Ofer Feinerman , Leor Gruendlinger , Elisha Moses , Jordi Soriano , Tsvi Tlusty

This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models…

Many natural and man-made network systems need to maintain certain patterns, such as working at equilibria or limit cycles, to function properly. Thus, the ability to stabilize such patterns is crucial. Most of the existing studies on…

Optimization and Control · Mathematics 2025-09-30 Alberto Maria Nobili , Yuzhen Qin , Carlo Alberto Avizzano , Danielle S. Bassett , Fabio Pasqualetti

By retracing my scientific journey that began 20 years ago, I highlight in this thesis the need to consider the organization of the brain, which is certainly globally hierarchical, but also highly distributed and mixed in the neuronal…

Neurons and Cognition · Quantitative Biology 2025-01-03 David Thura

Non-reciprocal interactions are a defining feature of many complex systems, biological, ecological, and technological, often pushing them far from equilibrium and enabling rich dynamical responses. These asymmetries can arise at multiple…

Biological Physics · Physics 2026-02-17 Anna Poggialini , Serena Di Santo , Pablo Villegas , Andrea Gabrielli , Miguel A. Muñoz

Neuromorphic computing seeks to replicate the remarkable efficiency, flexibility, and adaptability of the human brain in artificial systems. Unlike conventional digital approaches, which suffer from the Von Neumann bottleneck and depend on…

Artificial Intelligence · Computer Science 2025-11-04 Marcel van Gerven

In network science complex systems are represented as a mathematical graphs consisting of a set of nodes representing the components and a set of edges representing their interactions. The framework of networks has led to significant…

Physics and Society · Physics 2022-04-07 Alexandre Bovet , Hernán A. Makse

A fundamental understanding of the network architecture of the brain is necessary for the further development of theories explicating circuit function. Perhaps as a derivative of its initial application to abstract informational systems,…

Neurons and Cognition · Quantitative Biology 2018-07-13 Jennifer Stiso , Danielle Bassett

We study a mathematical model of biological neuronal networks composed by any finite number $N \geq 2$ of non necessarily identical cells. The model is a deterministic dynamical system governed by finite-dimensional impulsive differential…

Biological Physics · Physics 2013-11-19 Eleonora Catsigeras

A neuron transforms its input into output spikes, and this transformation is the basic unit of computation in the nervous system. The spiking response of the neuron to a complex, time-varying input can be predicted from the detailed…

Neurons and Cognition · Quantitative Biology 2011-12-19 Michael Famulare , Adrienne Fairhall

Linear Regression and neural networks are widely used to model data. Neural networks distinguish themselves from linear regression with their use of activation functions that enable modeling nonlinear functions. The standard argument for…

Machine Learning · Computer Science 2024-01-02 Anish Lakkapragada

Living systems implement and execute an extraordinary plethora of computational tasks. The inherent degree of large scale coordination emerges as a global property, from the intricate sea of microscopic interactions. The brain, with its…

Disordered Systems and Neural Networks · Physics 2018-01-03 Duccio Fanelli , Francesco Ginelli , Roberto Livi , Niccolò Zagli , Clement Zankoc

Functional networks provide a topological description of activity patterns in the brain, as they stem from the propagation of neural activity on the underlying anatomical or structural network of synaptic connections. This latter is well…

Disordered Systems and Neural Networks · Physics 2021-02-11 Ali Safari , Paolo Moretti , Ibai Diez , Jesus M. Cortes , Miguel Ángel Muñoz

Dynamical systems theory has long provided a foundation for understanding evolving phenomena across scientific domains. Yet, the application of this theory to complex real-world systems remains challenging due to issues in mathematical…

Machine Learning · Computer Science 2024-11-05 Samuel A. Moore , Brian P. Mann , Boyuan Chen

Neuroscience has long informed the development of artificial neural networks, but the success of modern architectures invites, in turn, the converse: can modern networks teach us lessons about brain function? Here, we examine the structure…

Neurons and Cognition · Quantitative Biology 2026-03-17 Peter Koenig , Mario Negrello

Recent advances in computational models of signal propagation and routing in the human brain have underscored the critical role of white matter structure. A complementary approach has utilized the framework of network control theory to…

Neurons and Cognition · Quantitative Biology 2021-03-15 Pragya Srivastava , Erfan Nozari , Jason Z. Kim , Harang Ju , Dale Zhou , Cassiano Becker , Fabio Pasqualetti , Danielle S. Bassett

Understanding the human brain remains the Holy Grail in biomedical science, and arguably in all of the sciences. Our brains represent the most complex systems in the world (and some contend the universe) comprising nearly one hundred…

Quantitative Methods · Quantitative Biology 2016-02-03 Sean L. Simpson , Paul J. Laurienti