Phenomenological modeling of diverse and heterogeneous synaptic dynamics at natural density
Abstract
This chapter sheds light on the synaptic organization of the brain from the perspective of computational neuroscience. It provides an introductory overview on how to account for empirical data in mathematical models, implement such models in software, and perform simulations reflecting experiments. This path is demonstrated with respect to four key aspects of synaptic signaling: the connectivity of brain networks, synaptic transmission, synaptic plasticity, and the heterogeneity across synapses. Each step and aspect of the modeling and simulation workflow comes with its own challenges and pitfalls, which are highlighted and addressed.
Keywords
Cite
@article{arxiv.2212.05354,
title = {Phenomenological modeling of diverse and heterogeneous synaptic dynamics at natural density},
author = {Agnes Korcsak-Gorzo and Charl Linssen and Jasper Albers and Stefan Dasbach and Renato Duarte and Susanne Kunkel and Abigail Morrison and Johanna Senk and Jonas Stapmanns and Tom Tetzlaff and Markus Diesmann and Sacha J. van Albada},
journal= {arXiv preprint arXiv:2212.05354},
year = {2024}
}
Comments
38 pages, 5 figures, LaTeX; added two figures, clarified and extended formulations, updated format, added references