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Related papers: Molecular Docking with Gaussian Boson Sampling

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We present a highly efficient molecular dynamics scheme for calculating the concentration profile of dopants implanted in group-IV alloy, and III-V zinc blende structure materials. Our program incorporates methods for reducing computational…

Materials Science · Physics 2009-10-31 Keith M. Beardmore , Niels Gronbech-Jensen

Gaussian states, operations, and measurements are central building blocks for continuous-variable quantum information processing which paves the way for abundant applications, especially including network-based quantum computation and…

Quantum Physics · Physics 2021-07-06 Mengzhen Zhang

Machine learning is widely applied in modern society, but has yet to capitalise on the unique benefits offered by quantum resources. Boson sampling -- a quantum-interference based sampling protocol -- is a resource that is classically hard…

Determining the optimal number and identity of structural clusters from an ensemble of molecular configurations continues to be a challenge. Recent structural clustering methods have focused on the use of internal coordinates due to the…

Chemical Physics · Physics 2023-01-11 Heidi Klem , Glen M. Hocky , Martin McCullagh

The behaviour of molecules in space is to a large extent governed by where they freeze out or sublimate. The molecular binding energy is thus an important parameter for many astrochemical studies. This parameter is usually determined with…

Astrophysics of Galaxies · Physics 2022-10-05 Torben Villadsen , Niels F. W. Ligterink , Mie Andersen

Molecular docking that predicts the bound structures of small molecules (ligands) to their protein targets, plays a vital role in drug discovery. However, existing docking methods often face limitations: they either overlook crucial…

Quantitative Methods · Quantitative Biology 2025-02-24 Zizhuo Zhang , Lijun Wu , Kaiyuan Gao , Jiangchao Yao , Tao Qin , Bo Han

Recent claims of achieving exponential quantum advantage have attracted attention to Gaussian boson sampling (GBS), a potential application of which is dense subgraph finding. We investigate the effects of sources of error including loss…

Quantum Physics · Physics 2023-02-01 Naomi R. Solomons , Oliver F. Thomas , Dara P. S. McCutcheon

Boson sampling is a specific quantum computation, which is likely hard to implement efficiently on a classical computer. The task is to sample the output photon number distribution of a linear optical interferometric network, which is fed…

The development of tailored materials for specific applications is an active field of research in chemistry, material science and drug discovery. The number of possible molecules that can be obtained from a set of atomic species grow…

Gaussian boson sampling (GBS) is a model of nonuniversal quantum computation that claims to demonstrate quantum supremacy with current technologies. This model entails sampling photocounting events from a multimode Gaussian state at the…

Quantum Physics · Physics 2024-10-22 I. S. Yeremenko , M. A. Dmytruk , A. A. Semenov

Boson sampling has emerged as an important tool to demonstrate the difference between quantum and classical computers and has attracted the interest of experimentalists and theoreticians. In this work we study Boson sampling from general,…

Quantum Physics · Physics 2024-03-27 Craig S. Hamilton , Igor Jex

Protein-ligand docking is an in silico tool used to screen potential drug compounds for their ability to bind to a given protein receptor within a drug-discovery campaign. Experimental drug screening is expensive and time consuming, and it…

There is a large body of evidence for the potential of greater computational power using information carriers that are quantum mechanical over those governed by the laws of classical mechanics. But the question of the exact nature of the…

Quantum Physics · Physics 2017-08-23 A. P. Lund , Michael J. Bremner , T. C. Ralph

Selecting an effective docking algorithm is highly context-dependent, and no single method performs reliably across structural, chemical, or protocol regimes. We introduce MolAS, a lightweight algorithm selection system that predicts…

Quantitative Methods · Quantitative Biology 2025-12-03 Jiabao Brad Wang , Siyuan Cao , Hongxuan Wu , Yiliang Yuan , Mustafa Misir

Sampling the distribution of bosons that have undergone a random unitary evolution is strongly believed to be a computationally hard problem. Key to outperforming classical simulations of this task is to increase both the number of input…

Important objectives in cancer research are the prediction of a patient's risk based on molecular measurements such as gene expression data and the identification of new prognostic biomarkers (e.g. genes). In clinical practice, this is…

Applications · Statistics 2020-04-17 Katrin Madjar , Manuela Zucknick , Katja Ickstadt , Jörg Rahnenführer

Boson sampling is a problem intractable for classical computers, but can be naturally solved on a specialized photonic quantum simulator which requires less resources than building a universal quantum computer. The biggest challenge to…

When a highly charged globular macromolecule, such as a dendritic polyelectrolyte or charged nanogel, is immersed into a physiological electrolyte solution, monovalent and divalent counterions from the solution bind to the macromolecule in…

Soft Condensed Matter · Physics 2020-08-26 Rohit Nikam , Xiao Xu , Matej Kanduč , Joachim Dzubiella

Demonstration of quantum advantage for classical machine learning tasks remains a central goal for quantum technologies and artificial intelligence. Two major bottlenecks to this goal are the high dimensionality of practical datasets and…

Quantum Physics · Physics 2025-10-16 Mohammad Sharifian , Abolfazl Bayat

Analyzing the properties of complex quantum systems is crucial for further development of quantum devices, yet this task is typically challenging and demanding with respect to required amount of measurements. A special attention to this…