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Next-generation sequencing technologies now constitute a method of choice to measure gene expression. Data to analyze are read counts, commonly modeled using Negative Binomial distributions. A relevant issue associated with this…

Methodology · Statistics 2014-11-10 Elisabetta Bonafede , Franck Picard , Stéphane Robin , Cinzia Viroli

Parameter-transfer is a well-known and versatile approach for meta-learning, with applications including few-shot learning, federated learning, and reinforcement learning. However, parameter-transfer algorithms often require sharing models…

Machine Learning · Computer Science 2020-02-24 Jeffrey Li , Mikhail Khodak , Sebastian Caldas , Ameet Talwalkar

Phenotypic drug discovery has attracted widespread attention because of its potential to identify bioactive molecules. Transcriptomic profiling provides a comprehensive reflection of phenotypic changes in cellular responses to external…

Machine Learning · Computer Science 2025-01-16 Hui Liu , Shikai Jin

While modern machine learning models rely on increasingly large training datasets, data is often limited in privacy-sensitive domains. Generative models trained with differential privacy (DP) on sensitive data can sidestep this challenge,…

Machine Learning · Statistics 2024-01-02 Tim Dockhorn , Tianshi Cao , Arash Vahdat , Karsten Kreis

Accurate phenotype prediction from RNA sequencing (RNA-seq) data is essential for diagnosis, biomarker discovery, and personalized medicine. Deep learning models have demonstrated strong potential to outperform classical machine learning…

Machine Learning · Computer Science 2026-03-10 Kevin Dradjat , Massinissa Hamidi , Blaise Hanczar

Differential privacy allows bounding the influence that training data records have on a machine learning model. To use differential privacy in machine learning, data scientists must choose privacy parameters $(\epsilon,\delta)$. Choosing…

Cryptography and Security · Computer Science 2021-07-21 Daniel Bernau , Günther Eibl , Philip W. Grassal , Hannah Keller , Florian Kerschbaum

Gene expression analysis is a critical method for cancer classification, enabling precise diagnoses through the identification of unique molecular signatures associated with various tumors. Identifying cancer-specific genes from gene…

Quantitative Methods · Quantitative Biology 2024-10-11 Farzana Tabassum , Sabrina Islam , Siana Rizwan , Masrur Sobhan , Tasnim Ahmed , Sabbir Ahmed , Tareque Mohmud Chowdhury

With the increasing demands for privacy protection, many privacy-preserving machine learning systems were proposed in recent years. However, most of them cannot be put into production due to their slow training and inference speed caused by…

Cryptography and Security · Computer Science 2020-08-19 Fei Zheng

Differentially private learning on real-world data poses challenges for standard machine learning practice: privacy guarantees are difficult to interpret, hyperparameter tuning on private data reduces the privacy budget, and ad-hoc privacy…

Machine Learning · Statistics 2018-12-10 Koen Lennart van der Veen , Ruben Seggers , Peter Bloem , Giorgio Patrini

Transfer learning through the use of pre-trained models has become a growing trend for the machine learning community. Consequently, numerous pre-trained models are released online to facilitate further research. However, it raises…

Machine Learning · Computer Science 2022-07-26 Zhuowen Yuan , Fan Wu , Yunhui Long , Chaowei Xiao , Bo Li

Deep learning models have demonstrated superior performance in several application problems, such as image classification and speech processing. However, creating a deep learning model using health record data requires addressing certain…

Machine Learning · Computer Science 2021-12-14 Amirsina Torfi , Edward A. Fox , Chandan K. Reddy

The proliferation of deep learning applications in healthcare calls for data aggregation across various institutions, a practice often associated with significant privacy concerns. This concern intensifies in medical image analysis, where…

Machine Learning · Computer Science 2023-07-03 Kishore Babu Nampalle , Pradeep Singh , Uppala Vivek Narayan , Balasubramanian Raman

Linear programming is a fundamental tool in a wide range of decision systems. However, without privacy protections, sharing the solution to a linear program may reveal information about the underlying data used to formulate it, which may be…

Optimization and Control · Mathematics 2025-11-11 Alexander Benvenuti , Brendan Bialy , Miriam Dennis , Matthew Hale

Privacy-preserving distributed machine learning becomes increasingly important due to the recent rapid growth of data. This paper focuses on a class of regularized empirical risk minimization (ERM) machine learning problems, and develops…

Machine Learning · Computer Science 2016-03-11 Tao Zhang , Quanyan Zhu

Protecting sensitive information against data exploiting attacks is an emerging research area in data mining. Over the past, several different methods have been introduced to protect individual privacy from such attacks while maximizing…

Cryptography and Security · Computer Science 2021-07-29 Hung Nguyen , Di Zhuang , Pei-Yuan Wu , Morris Chang

A major challenge for machine learning is increasing the availability of data while respecting the privacy of individuals. Here we combine the provable privacy guarantees of the differential privacy framework with the flexibility of…

Machine Learning · Statistics 2019-01-18 Michael Thomas Smith , Max Zwiessele , Neil D. Lawrence

Privacy preservation has become a critical concern in high-dimensional data analysis due to the growing prevalence of data-driven applications. Since its proposal, sliced inverse regression has emerged as a widely utilized statistical…

Machine Learning · Statistics 2025-04-08 Xintao Xia , Linjun Zhang , Zhanrui Cai

Privacy-preserving genomic data sharing is prominent to increase the pace of genomic research, and hence to pave the way towards personalized genomic medicine. In this paper, we introduce ($\epsilon , T$)-dependent local differential…

Cryptography and Security · Computer Science 2021-02-16 Emre Yilmaz , Tianxi Ji , Erman Ayday , Pan Li

We introduce an end-to-end private deep learning framework, applied to the task of predicting 30-day readmission from electronic health records. By using differential privacy during training and homomorphic encryption during inference, we…

Cryptography and Security · Computer Science 2018-11-27 Edward Chou , Thao Nguyen , Josh Beal , Albert Haque , Li Fei-Fei

Broad adoption of machine learning techniques has increased privacy concerns for models trained on sensitive data such as medical records. Existing techniques for training differentially private (DP) models give rigorous privacy guarantees,…

Machine Learning · Statistics 2019-10-04 Zhengli Zhao , Nicolas Papernot , Sameer Singh , Neoklis Polyzotis , Augustus Odena
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