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Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning…

Medical Physics · Physics 2025-08-12 Hao Peng , Yuanyuan Zhang , Steve Jiang , Robert Timmerman , John Minna

The performance of differentially private machine learning can be boosted significantly by leveraging the transfer learning capabilities of non-private models pretrained on large public datasets. We critically review this approach. We…

Machine Learning · Computer Science 2024-07-18 Florian Tramèr , Gautam Kamath , Nicholas Carlini

Pre-training large transformer models with in-domain data improves domain adaptation and helps gain performance on the domain-specific downstream tasks. However, sharing models pre-trained on potentially sensitive data is prone to…

Computation and Language · Computer Science 2025-08-14 Ying Yin , Ivan Habernal

Deep learning based electroencephalography (EEG) signal processing methods are known to suffer from poor test-time generalization due to the changes in data distribution. This becomes a more challenging problem when privacy-preserving…

Private data analysis suffers a costly curse of dimensionality. However, the data often has an underlying low-dimensional structure. For example, when optimizing via gradient descent, the gradients often lie in or near a low-dimensional…

Cryptography and Security · Computer Science 2021-08-12 Vikrant Singhal , Thomas Steinke

In machine learning, classification models need to be trained in order to predict class labels. When the training data contains personal information about individuals, collecting training data becomes difficult due to privacy concerns.…

Machine Learning · Computer Science 2019-05-06 Emre Yilmaz , Mohammad Al-Rubaie , J. Morris Chang

Diferentially private (DP) synthetic datasets are a powerful approach for training machine learning models while respecting the privacy of individual data providers. The effect of DP on the fairness of the resulting trained models is not…

Machine Learning · Statistics 2021-06-21 Mayana Pereira , Meghana Kshirsagar , Sumit Mukherjee , Rahul Dodhia , Juan Lavista Ferres

This study investigates the risks of exposing confidential chemical structures when machine learning models trained on these structures are made publicly available. We use membership inference attacks, a common method to assess privacy that…

Cryptography and Security · Computer Science 2025-04-18 Fabian P. Krüger , Johan Östman , Lewis Mervin , Igor V. Tetko , Ola Engkvist

A recent study by De et al. (2022) has reported that large-scale representation learning through pre-training on a public dataset significantly enhances differentially private (DP) learning in downstream tasks, despite the high…

Machine Learning · Computer Science 2024-10-15 Chendi Wang , Yuqing Zhu , Weijie J. Su , Yu-Xiang Wang

Differential privacy (DP) is a prominent method for protecting information about individuals during data analysis. Training neural networks with differentially private stochastic gradient descent (DPSGD) influences the model's learning…

Machine Learning · Computer Science 2025-10-10 Lea Demelius , Dominik Kowald , Simone Kopeinik , Roman Kern , Andreas Trügler

Privacy preserving in machine learning is a crucial issue in industry informatics since data used for training in industries usually contain sensitive information. Existing differentially private machine learning algorithms have not…

Machine Learning · Computer Science 2020-10-08 Tao Zhang , Tianqing Zhu , Ping Xiong , Huan Huo , Zahir Tari , Wanlei Zhou

Generative models trained with Differential Privacy (DP) are becoming increasingly prominent in the creation of synthetic data for downstream applications. Existing literature, however, primarily focuses on basic benchmarking datasets and…

Cryptography and Security · Computer Science 2024-02-08 Dingfan Chen , Marie Oestreich , Tejumade Afonja , Raouf Kerkouche , Matthias Becker , Mario Fritz

In large-scale statistical learning, data collection and model fitting are moving increasingly toward peripheral devices---phones, watches, fitness trackers---away from centralized data collection. Concomitant with this rise in…

Machine Learning · Statistics 2019-06-04 Abhishek Bhowmick , John Duchi , Julien Freudiger , Gaurav Kapoor , Ryan Rogers

Differential privacy (DP) allows the quantification of privacy loss when the data of individuals is subjected to algorithmic processing such as machine learning, as well as the provision of objective privacy guarantees. However, while…

Cryptography and Security · Computer Science 2021-11-30 Tamara T. Mueller , Alexander Ziller , Dmitrii Usynin , Moritz Knolle , Friederike Jungmann , Daniel Rueckert , Georgios Kaissis

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Machine Learning · Computer Science 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

The characterization of drug-protein interactions is crucial in the high-throughput screening for drug discovery. The deep learning-based approaches have attracted attention because they can predict drug-protein interactions without…

Machine Learning · Computer Science 2020-12-22 QHwan Kim , Joon-Hyuk Ko , Sunghoon Kim , Nojun Park , Wonho Jhe

Label differential privacy (DP) is a framework that protects the privacy of labels in training datasets, while the feature vectors are public. Existing approaches protect the privacy of labels by flipping them randomly, and then train a…

Machine Learning · Computer Science 2024-05-27 Puning Zhao , Rongfei Fan , Huiwen Wu , Qingming Li , Jiafei Wu , Zhe Liu

One of the big challenges in machine learning applications is that training data can be different from the real-world data faced by the algorithm. In language modeling, users' language (e.g. in private messaging) could change in a year and…

Computation and Language · Computer Science 2018-03-07 Vadim Popov , Mikhail Kudinov , Irina Piontkovskaya , Petr Vytovtov , Alex Nevidomsky

An important problem in deep learning is the privacy and security of neural networks (NNs). Both aspects have long been considered separately. To date, it is still poorly understood how privacy enhancing training affects the robustness of…

Cryptography and Security · Computer Science 2021-05-18 Franziska Boenisch , Philip Sperl , Konstantin Böttinger

Gene expression profiles have been widely used to characterize patterns of cellular responses to diseases. As data becomes available, scalable learning toolkits become essential to processing large datasets using deep learning models to…

Machine Learning · Computer Science 2019-02-01 Ya Ju Fan , Jonathan E. Allen , Sam Ade Jacobs , Brian C. Van Essen