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Clinical prediction models are estimated using a sample of limited size from the target population, leading to uncertainty in predictions, even when the model is correctly specified. Generally, not all patient profiles are observed…

Methodology · Statistics 2024-02-09 Doranne Thomassen , Saskia le Cessie , Hans van Houwelingen , Ewout Steyerberg

In the random-effects model of meta-analysis a canonical representation of the restricted likelihood function is obtained. This representation relates the mean effect and the heterogeneity variance estimation problems. An explicit form of…

Statistics Theory · Mathematics 2014-10-28 Andrew L. Rukhin

Background: Pairwise and network meta-analyses using fixed effect and random effects models are commonly applied to synthesise evidence from randomised controlled trials. The models differ in their assumptions and the interpretation of the…

Methodology · Statistics 2017-08-04 Shijie Ren , Jeremy E. Oakley , John W. Stevens

To analyze the uncertain data frequently encountered in practice, this paper proposes novel fixed-effects models that incorporate an uncertain measure to investigate variables of interest and nuisance variables in factor designs. First, an…

Methodology · Statistics 2026-03-18 Fan Zhang , Zhiming Li

Cochran's $Q$ statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value is also used for estimation of between-study variance $\tau^2$. Cochran's $Q$, or $Q_{IV}$, uses estimated inverse-variance weights…

Methodology · Statistics 2021-03-08 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

Meta-analysis can be formulated as combining $p$-values across studies into a joint $p$-value function, from which point estimates and confidence intervals can be derived. We extend the meta-analytic estimation framework based on combined…

Methodology · Statistics 2025-10-21 David Kronthaler , Leonhard Held

It has been a long history in testing whether a mean vector with a fixed dimension has a specified value. Some well-known tests include the Hotelling $T^2$-test and the empirical likelihood ratio test proposed by Owen [Biometrika 75 (1988)…

Methodology · Statistics 2014-05-21 Liang Peng , Yongcheng Qi , Fang Wang

We consider large-scale studies in which it is of interest to test a very large number of hypotheses, and then to estimate the effect sizes corresponding to the rejected hypotheses. For instance, this setting arises in the analysis of gene…

Methodology · Statistics 2015-03-31 Kean Ming Tan , Noah Simon , Daniela Witten

Research often necessitates of samples, yet obtaining large enough samples is not always possible. When it is, the researcher may use one of two methods for deciding upon the required sample size: rules-of-thumb, quick yet uncertain, and…

Methodology · Statistics 2016-04-08 Jose D. Perezgonzalez

After rejecting the null hypothesis in the analysis of variance, the next step is to make the pairwise comparisons to find out differences in means. The purpose of this paper is threefold. The foremost aim is to suggest expression for…

Methodology · Statistics 2023-06-22 Elsayed A. H. Elamir

Science students must deal with the errors inherent to all physical measurements and be conscious of the necessity to express their as a best estimate and a range of uncertainty. Errors are routinely classified as statistical or systematic.…

Physics Education · Physics 2020-06-03 Martin Monteiro , Cecilia Stari , Cecilia Cabeza , Arturo C. Marti

New Berry--Esseen-type bounds, with explicit constant factors, for the distribution of the Student statistic and, equivalently, for that of the self-normalized sum of independent zero-mean random variables are obtained. These bounds are…

Statistics Theory · Mathematics 2015-03-17 Iosif Pinelis

Traditional meta-analysis assumes that the effect sizes estimated in individual studies follow a Gaussian distribution. However, this distributional assumption is not always satisfied in practice, leading to potentially biased results. In…

Methodology · Statistics 2024-04-23 Wei Liang , Haicheng Huang , Hongsheng Dai , Yinghui Wei

Effect size estimates are thought to capture the collective, two-way response to an intervention or exposure in a three-way problem among the intervention/exposure, various confounders and the outcome. For meaningful causal inference from…

Methodology · Statistics 2024-02-08 Orestis Loukas , Ho Ryun Chung

Measuring dependence between two events, or equivalently between two binary random variables, amounts to expressing the dependence structure inherent in a $2\times 2$ contingency table in a real number between $-1$ and $1$. Countless such…

Methodology · Statistics 2025-11-13 Marc-Oliver Pohle , Timo Dimitriadis , Jan-Lukas Wermuth

We consider a Bayesian framework for estimating the sample size of a clinical trial. The new approach, called BESS, is built upon three pillars: Sample size of the trial, Evidence from the observed data, and Confidence of the final decision…

Methodology · Statistics 2026-01-21 Dehua Bi , Yuan Ji

In this paper we shall consider some famous means such as arithmetic, harmonic, geometric, root square mean, etc. Considering the difference of these means, we can establish. some inequalities among them. Interestingly, the difference of…

Information Theory · Computer Science 2011-03-29 Inder Jeet Taneja

Effect size indices are useful parameters that quantify the strength of association and are unaffected by sample size. There are many available effect size parameters and estimators, but it is difficult to compare effect sizes across…

Computation · Statistics 2023-02-27 Megan Jones , Kaidi Kang , Simon Vandekar

Researchers increasingly use meta-analysis to synthesize the results of several studies in order to estimate a common effect. When the outcome variable is continuous, standard meta-analytic approaches assume that the primary studies report…

Robustness of any statistics depends upon the number of assumptions it makes about the measured data. We point out the advantages of median statistics using toy numerical experiments and demonstrate its robustness, when the number of…

Cosmology and Nongalactic Astrophysics · Physics 2017-02-14 Suryarao Bethapudi , Shantanu Desai