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Single-cell sequencing is revolutionizing biology by enabling detailed investigations of cell-state transitions. Many biological processes unfold along continuous trajectories, yet it remains challenging to extract smooth, low-dimensional…

Machine Learning · Statistics 2025-06-30 Rong Ma , Xi Li , Jingyuan Hu , Bin Yu

The study of complex systems has attracted widespread attention from researchers in the fields of natural sciences, social sciences, and engineering. Prediction is one of the central issues in this field. Although most related studies have…

Physics and Society · Physics 2025-10-21 En Xu , Yilin Bi , Hongwei Hu , Xin Chen , Zhiwen Yu , Yong Li , Yanqing Hu , Tao Zhou

Conformal Prediction (CP) is a popular method for uncertainty quantification with machine learning models. While conformal prediction provides probabilistic guarantees regarding the coverage of the true label, these guarantees are agnostic…

Machine Learning · Computer Science 2025-10-21 Aditya T. Vadlamani , Anutam Srinivasan , Pranav Maneriker , Ali Payani , Srinivasan Parthasarathy

Scientific workflows are becoming increasingly popular for compute-intensive and data-intensive scientific applications. The vision and promise of scientific workflows includes rapid, easy workflow design, reuse, scalable execution, and…

Databases · Computer Science 2013-11-26 Víctor Cuevas-Vicenttín , Saumen Dey , Sven Köhler , Sean Riddle , Bertram Ludäscher

In this thesis a comprehensive verification framework is proposed to contend with some important issues in composability verification and a verification process is suggested to verify composability of different kinds of systems models, such…

Software Engineering · Computer Science 2023-01-10 Imran Mahmood

Privacy-preserving computation (PPC) methods, such as secure multiparty computation (MPC) and homomorphic encryption (HE), are deployed increasingly often to guarantee data confidentiality in computations over private, distributed data.…

Cryptography and Security · Computer Science 2024-04-17 Tariq Bontekoe , Dimka Karastoyanova , Fatih Turkmen

Estimating the reliability of individual predictions is key to increase the adoption of computational models and artificial intelligence in preclinical drug discovery, as well as to foster its application to guide decision making in…

Quantitative Methods · Quantitative Biology 2019-08-13 Isidro Cortés-Ciriano , Andreas Bender

In this paper, we provide a theoretical analysis of closed-loop properties of a simple data-driven model predictive control (MPC) scheme. The formulation does not involve any terminal ingredients, thus allowing for a simple implementation…

Optimization and Control · Mathematics 2024-12-04 Joscha Bongard , Julian Berberich , Johannes Köhler , Frank Allgöwer

The fundamental challenge of drawing causal inference is that counterfactual outcomes are not fully observed for any unit. Furthermore, in observational studies, treatment assignment is likely to be confounded. Many statistical methods have…

Methodology · Statistics 2022-08-01 Harsh Parikh , Carlos Varjao , Louise Xu , Eric Tchetgen Tchetgen

We propose a purely data-driven model predictive control (MPC) scheme to control unknown linear time-invariant systems with guarantees on stability and constraint satisfaction in the presence of noisy data. The scheme predicts future…

Systems and Control · Electrical Eng. & Systems 2021-03-25 Julian Berberich , Johannes Köhler , Matthias A. Müller , Frank Allgöwer

Reproducibility is widely acknowledged as a fundamental principle in scientific research. Currently, the scientific community grapples with numerous challenges associated with reproducibility, often referred to as the ''reproducibility…

Software Engineering · Computer Science 2024-09-16 Benjamin A. Antunes , David R. C. Hill

In scientific inference problems, the underlying statistical modeling assumptions have a crucial impact on the end results. There exist, however, only a few automatic means for validating these fundamental modelling assumptions. The…

Methodology · Statistics 2019-05-21 Andreas Svensson , Dave Zachariah , Petre Stoica , Thomas B. Schön

Accountability is widely understood as a goal for well governed computer systems, and is a sought-after value in many governance contexts. But how can it be achieved? Recent work on standards for governable artificial intelligence systems…

Computers and Society · Computer Science 2021-08-23 Joshua A. Kroll

Studying the reliability of complex systems using machine learning techniques involves facing a series of technical and practical challenges, ranging from the intrinsic nature of the system and data to the difficulties in modeling and…

Machine Learning · Computer Science 2024-10-08 Maria Luz Gamiz , Fernando Navas-Gomez , Rafael Nozal-Cañadas , Rocio Raya-Miranda

Cyber Physical Systems solve complex problems through their tight integration between the physical and computational components. Therefore, the reliability of a complex system is the most critical requirement for the cyber physical system…

Software Engineering · Computer Science 2020-10-13 Nazakat Ali , Manzoor Hussain , Youngjae Kim , Jang-Eui Hong

Cloud native systems are processing large amounts of personal data through numerous and possibly multi-paradigmatic data stores (e.g., relational and non-relational databases). From a privacy engineering perspective, a core challenge is to…

Cryptography and Security · Computer Science 2023-09-06 Elias Grünewald , Leonard Schurbert

Computational methods have reshaped the landscape of modern biology. While the biomedical community is increasingly dependent on computational tools, the mechanisms ensuring open data, open software, and reproducibility are variably…

Other Quantitative Biology · Quantitative Biology 2020-07-28 Jaqueline J. Brito , Jun Li , Jason H. Moore , Casey S. Greene , Nicole A. Nogoy , Lana X. Garmire , Serghei Mangul

Inferences about hypotheses are ubiquitous in the cognitive sciences. Bayes factors provide one general way to compare different hypotheses by their compatibility with the observed data. Those quantifications can then also be used to choose…

We present recent advances in formal verification and control for autonomous systems with practical safety guarantees enabled by conformal prediction (CP), a statistical tool for uncertainty quantification. This survey is particularly…

Systems and Control · Electrical Eng. & Systems 2025-08-19 Lars Lindemann , Yiqi Zhao , Xinyi Yu , George J. Pappas , Jyotirmoy V. Deshmukh

Validation of prediction uncertainty (PU) is becoming an essential task for modern computational chemistry. Designed to quantify the reliability of predictions in meteorology, the calibration-sharpness (CS) framework is now widely used to…

Chemical Physics · Physics 2022-10-03 Pascal Pernot
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