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Smoking is one of the main risk factors that has affected human mortality and life expectancy over the past century. Smoking accounts for a large part of the nonlinearities in the growth of life expectancy and of the geographic and sex…

Applications · Statistics 2019-10-29 Yicheng Li , Adrian E. Raftery

Will the United Kingdom's ageing population be fit and independent, or suffer from greater chronic ill health? Healthy life expectancy is commonly used to assess this: it is an estimate of how many years are lived in good health over the…

Statistics Theory · Mathematics 2007-06-13 Ehsan Khoman , Martin Weale

A new stochastic method for describing mortality is proposed and explored. It is based on differences of observed times series of the transform $\log(-\log x)$ of survival probabilities which seem to follow simple patterns over the years.…

Applications · Statistics 2015-02-26 Meitner Cadena

Background: Frailty, a state of increased vulnerability to adverse health outcomes, has garnered significant attention in research and clinical practice. Existing constructs aggregate clinical features or health deficits into a single…

Applications · Statistics 2024-03-04 Lara Johnson , Bruce Guthrie , Paul A T Kelly , Atul Anand , Alan Marshall , Sohan Seth

Entropic aging consists in a progressive slowing down of the low-temperature dynamics of a glassy system due to the rarefaction of downwards directions on the energy landscape, as lower and lower energy levels are reached. A prototypical…

Statistical Mechanics · Physics 2010-07-23 Eric Bertin

The thresholding of time series of activity or intensity is frequently used to define and differentiate events. This is either implicit, for example due to resolution limits, or explicit, in order to filter certain small scale physics from…

Data Analysis, Statistics and Probability · Physics 2015-05-20 Francesc Font-Clos , Gunnar Pruessner , Anna Deluca , Nicholas R. Moloney

Author's early work on aging is developed to yield a relationship between life spans and the velocity of aging. The mathematical analysis shows that the mean extent of the advancement of aging throughout one's life is conserved, or…

Populations and Evolution · Quantitative Biology 2007-05-23 Kazumi Suematsu

Motivated by improving mortality tables from human demography databases, we investigate statistical inference of a stochastic age-evolving density of a population alimented by time inhomogeneous mortality and fertility. Asymptotics are…

Statistics Theory · Mathematics 2019-03-05 Alexandre Boumezoued , Marc Hoffmann , Paulien Jeunesse

The issue of longevity has been long time recognized as one of key concepts in demography. A particular aspect of longevity addressed in this paper is the difference in average observed duration of life for female and male population,…

Physics and Society · Physics 2019-05-09 Toni Cosic , Roko Misetic , Hrvoje Stefancic

The unprecedented extension of the human lifespan necessitates a parallel evolution in how we quantify the quality of aging and its socioeconomic impact. Traditional metrics focusing on Healthspan (years free of disease) overlook the…

Quantitative Methods · Quantitative Biology 2026-03-19 Alex Zhavoronkov , Dominika Wilczok

Human aging is a process controlled by both genetics and environment. Many studies have been conducted to identify a subset of genes related to aging from the human genome. Biologists implicitly categorize age-related genes into genes that…

Genomics · Quantitative Biology 2023-11-17 Salman Mohamadi , Donald A. Adjeroh

Most studies on inequality in infant and child mortality compare average mortality rates between large groups of births, for example, comparing births from different countries, income groups, ethnicities, or different times. These studies…

Applications · Statistics 2019-12-23 Antonio P. Ramos , Robert E. Weiss

Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity…

Populations and Evolution · Quantitative Biology 2010-11-15 Byung Mook Weon , Jung Ho Je

We propose utilizing entropy as a diagnostic tool to distinguish between constant and dynamical dark energy models. Entropy, a measure of the system's disorder or information content, captures the complexity and evolution of the universe.…

General Relativity and Quantum Cosmology · Physics 2025-07-16 Tanisha Joshi

Improving health worldwide will require rigorous quantification of population-level trends in health status. However, global-level surveys are not available, forcing researchers to rely on fragmentary country-specific data of varying…

Methodology · Statistics 2014-05-20 Mariel M. Finucane , Christopher J. Paciorek , Goodarz Danaei , Majid Ezzati

Following our previous works on the health state of a population and the related health state function we proceed in developing a method to estimate the Healthy Life Expectancy in connection to the relative impact of the Mortality Area in…

Populations and Evolution · Quantitative Biology 2012-05-15 Christos H. Skiadas , Charilaos Skiadas

Suppose, contrary to fact, in 1950, we had put the cohort of 18 year old non-smoking American men on a stringent mandatory diet that guaranteed that no one would ever weigh more than their baseline weight established at age 18. How would…

Applications · Statistics 2008-02-06 James Robins

Accelerated brain aging has been consistently reported in patients with schizophrenia. Over the past decade, these findings have been replicated using the Brain Age paradigm, which applies machine learning techniques to estimate brain age…

Entropy has emerged as a dynamic, interdisciplinary, and widely accepted quantitative measure of uncertainty across different disciplines. A unified understanding of entropy measures, supported by a detailed review of their theoretical…

Probability · Mathematics 2025-03-21 Naveen Kumar , Ambesh Dixit , Vivek Vijay

Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clinical trials to track the therapeutic efficacy of…