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In life insurance, life tables are used to estimate the survival distribution of individuals from a given population. However, these tables only provide survival probabilities at integer ages but no information about the distribution of…

Risk Management · Quantitative Finance 2026-03-19 Jean-Loup Dupret , Edouard Motte

This research explores how total mortality figures relate to age-standardized death rates within the United States, using the complete historical record of national mortality statistics. Through a detailed investigation of both all-cause…

Other Quantitative Biology · Quantitative Biology 2026-01-21 Brandon Dunbar , Paramahansa Pramanik , Haley Kate Robinson

Entropy plays a key role in statistical physics of complex systems, which in general exhibit diverse aspects of emergence on different scales. However, it still remains not fully resolved how entropy varies with the coarse-graining level…

Statistical Mechanics · Physics 2017-08-07 Segun Goh , Jungzae Choi , MooYoung Choi , Byung-Gook Yoon

Infant deaths and old age deaths are very different. The former are mostly due to severe congenital malformations of one or a small number of specific organs. On the contrary, old age deaths are largely the outcome of a long process of…

Biological Physics · Physics 2021-06-17 Peter Richmond , Bertrand M. Roehner

In this paper, we affirm our earlier findings of evidence for a limit to human lifespan. In particular, we assess the analyses in extreme value theory (EVT) performed by Rootz\'en and Zholud. We find that their criticisms of our work are…

Applications · Statistics 2018-06-18 Brandon Milholland , Xiao Dong , Jan Vijg

The Gompertz law of mortality quantitatively describes the mortality rate of humans and almost all multicellular animals. However, its underlying kinetic mechanism is unclear. The Gompertz law cannot explain the effect of temperature on…

Populations and Evolution · Quantitative Biology 2015-02-04 Xiaoping Liu

Aging is a multidimensional process where phenotypes change at varying rates. Longitudinal studies of aging typically involve following a cohort of individuals over the course of several years. This design is hindered by cost, attrition,…

The association of equal heartbeat intervals with cardiac conditions and the effect of the equality on permutation-based time irreversibility are investigated in this paper. We measure the distributions of equal heartbeat intervals under…

Medical Physics · Physics 2020-08-20 Yao Wen-po , Yao Wen-li , Wang Jun

Complex fluids exhibit time-dependent changes in viscosity that have been ascribed to both thixotropy and aging. However, there is no consensus for which phenomenon is the origin of which changes. A novel thixotropic model is defined that…

Soft Condensed Matter · Physics 2008-08-26 Daniel Quemada

In reliability theory and survival analysis, the residual entropy is known as a measure suitable to describe the dynamic information content in stochastic systems conditional on survival. Aiming to analyze the variability of such…

Statistics Theory · Mathematics 2020-03-25 Antonio Di Crescenzo , Luca Paolillo

Identifying frail older adults in an ageing population is essential for improving healthcare services. This study proposes a composite indicator to assess individual frailty levels using administrative healthcare data. Given the complex and…

Methodology · Statistics 2025-10-07 Sara Rebottini , Pietro Belloni

Threshold and infrared divergences are studied as possible mechanisms of particle production and compared to the usual decay process in a model quantum field theory from which generalizations are obtained. A spectral representation of the…

High Energy Physics - Phenomenology · Physics 2022-03-16 Daniel Boyanovsky

Machine learning is a rapidly evolving field with a wide range of applications, including biological signal analysis, where novel algorithms often improve the state-of-the-art. However, robustness to algorithmic variability - measured by…

Signal Processing · Electrical Eng. & Systems 2024-02-16 Tobias Ettling , Sari Saba-Sadiya , Gemma Roig

The human electroencephalogram (EEG) of sleep undergoes profound changes with age. These changes can be conceptualized as "brain age", which can be compared to an age norm to reflect the deviation from normal aging process. Here, we develop…

We propose a method of estimating the Total Loss of Healthy Life Years based on the first exit time theory for a stochastic process, the resulting Health State Function and the Deterioration Function estimated as the curvature of the health…

Populations and Evolution · Quantitative Biology 2012-12-20 Christos H. Skiadas , Charilaos Skiadas

Complexity measures are introduced, that quantify the change of the natural entropy fluctuations at different length scales in time-series emitted from systems operating far from equilibrium. They identify impending sudden cardiac death…

Data Analysis, Statistics and Probability · Physics 2007-05-23 P. A. Varotsos , N. V. Sarlis , E. S. Skordas , M. S. Lazaridou

We consider a "length-biased" shift-dependent information measure, related to the differential entropy in which higher weight is assigned to large values of observed random variables. This allows us to introduce the notions of "weighted…

Statistics Theory · Mathematics 2011-06-27 Antonio Di Crescenzo , Maria Longobardi

At the physiological level, aging is neither rigid nor unchangeable. Instead, the molecular and mechanisms driving aging are sufficiently plastic that a variety of diverse interventions--dietary, pharmaceutical, and genetic--have been…

Quantitative Methods · Quantitative Biology 2018-08-28 Nicholas Stroustrup

Time perception is crucial for a coherent human experience. As life progresses, our perception of the passage of time becomes increasingly non-uniform, often feeling as though it accelerates with age. While various causes for this…

Neurons and Cognition · Quantitative Biology 2024-11-11 Enric Espel Sanchez