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Strategies based on the active targeting of tumor cells are emerging as smart and efficient nanomedical procedures. Folic acid (FA) is a vitamin and a well-established tumor targeting agent because of its strong affinity for the folate…

Materials Science · Physics 2022-08-22 Edoardo Donadoni , Paulo Siani , Giulia Frigerio , Cristiana Di Valentin

Metastatic cancer cells detect the direction of lymphatic flow by self-communication: they secrete and detect a chemical which, due to the flow, returns to the cell surface anisotropically. The secretion rate is low, meaning detection noise…

Biological Physics · Physics 2020-07-14 Sean Fancher , Michael Vennettilli , Nicholas Hilgert , Andrew Mugler

Breast cancer is the most common cancer among women worldwide. The human epidermal growth factor receptor 2 (HER2) with immunohistochemical (IHC) is widely used for pathological evaluation to provide the appropriate therapy for patients…

Quantitative Methods · Quantitative Biology 2022-03-08 Zichen Zhang , Lang Wang , Shuhao Wang

A Bayesian feature allocation model (FAM) is presented for identifying cell subpopulations based on multiple samples of cell surface or intracellular marker expression level data obtained by cytometry by time of flight (CyTOF). Cell…

Applications · Statistics 2020-02-21 Arthur Lui , Juhee Lee , Peter F. Thall , May Daher , Katy Rezvani , Rafet Barar

The achievement of all-fibre functional nano-modules for subcellular label-free measurement has long been pursued due to the limitations of manufacturing techniques. In this paper, a compact all-fibre label-free nano-sensor composed of a…

Auto-regressive neural sequence models have been shown to be effective across text generation tasks. However, their left-to-right decoding order prevents generation from being parallelized. Insertion Transformer (Stern et al., 2019) is an…

Computation and Language · Computer Science 2023-02-01 Zhisong Zhang , Yizhe Zhang , Bill Dolan

Excitation with entangled photon pairs may lead to an increase in the efficiency of two-photon absorption at low photon flux. The corresponding process, entangled two-photon absorption (E2PA), has been investigated in numerous theoretical…

We derive a factor graph EM (FGEM) algorithm, a technique that permits combined parameter estimation and statistical inference, to determine hidden kinetic microstates from patch clamp measurements. Using the cystic fibrosis transmembrane…

Quantitative Methods · Quantitative Biology 2021-06-18 Alexander S. Moffett , Guiying Cui , Peter J. Thomas , William D. Hunt , Nael A. McCarty , Ryan S. Westafer , Andrew W. Eckford

We report the radiation trapping effect inside a hollow-core photonic crystal fiber (PCF). An optical dipole trap was used to load and confine the atoms in the PCF without contacting the wall of the fiber. The transmission of a probe light…

Quantum Physics · Physics 2014-06-12 H. H. Jen , Chang-Yi Wang , Kevin C. J. Lee , Yi-Hsin Chen , Ite A. Yu

Action-detected two-dimensional electronic spectroscopy (A-2DES) could potentially be a versatile chemical tool with applicability across a range of photophysical observables such as photocurrent, photoionization, or fluorescence. However,…

Chemical Physics · Physics 2026-04-29 Sayan Ghosh , Amitav Sahu , Stephanie Gonzalez-Migoni , Thomas L. C. Jansen , Vivek Tiwari

A brief review of optical and Raman studies on the Fe-based superconductors is given, with special emphasis on the competing phenomenon in this system. Optical investigations on ReFeAsO (Re=rare-earth element) and AFe$_2$As$_2$…

Superconductivity · Physics 2015-05-13 W. Z. Hu , Q. M. Zhang , N. L. Wang

We monitored isotropic spreading of mouse embryonic fibroblasts on fibronectin-coated substrates. Cell adhesion area versus time was measured via total internal reflection fluorescence microscopy. Spreading proceeds in well-defined phases.…

Cell Behavior · Quantitative Biology 2009-11-10 H. -G. Doebereiner , B. J. Dubin-Thaler , G. Giannone , H. S. Xenias , M. P. Sheetz

Two-photon absorption (TPA) fluorescence of biomarkers has been decisive in advancing the fields of biosensing and deep-tissue in vivo imaging of live specimens. However, due to the extremely small TPA cross section and the quadratic…

Optics · Physics 2020-06-25 Tian Li , Fu Li , Charles Altuzarra , Anton Classen , Girish S. Agarwal

The notion of lasing with biologics has recently been realized and has since rapidly developed with the collective objective of creating lasers $\textit{in vivo}$. One limitation of achieving this goal is the requirement of exogenous laser…

Biological Physics · Physics 2017-07-03 Derrick Yong , Ding Ding

The electronic properties of graphene are unique and are attracting increased attention to this novel 2-dimensional system. Its photonic properties are not less impressive. For example, this single atomic layer absorbs through direct…

Materials Science · Physics 2009-12-25 Fengnian Xia , Thomas Mueller , Yu-ming Lin , Alberto Valdes-Garcia , Phaedon Avouris

We present a fiber-diffraction interferometer using a coherent fiber optic taper for optical testing in an uncontrolled environment. We use a coherent fiber optic taper and a single-mode fiber having thermally-expanded core. Part of the…

Optics · Physics 2015-05-19 Hagyong Kihm , Yun-Woo Lee

Surface lattice resonance supported on nanoparticle arrays is a promising candidate in enhancing fluorescent effects in both absorption and emission. The optical enhancement provided by surface lattice resonance is primarily through the…

Optics · Physics 2024-01-19 Joshua T. Y. Tse , Shunsuke Murai , Katsuhisa Tanaka

Transferable excited-state dynamics offer a route to efficient screening of photophysical behavior across molecular systems, but conventional nonadiabatic simulations remain prohibitively expensive. Here we introduce X-MACE, a transferable…

Chemical Physics · Physics 2026-04-15 Rhyan Barrett , Sophia Wesely , Julia Westermayr

The coupling between molecular exciton and gap plasmons plays a key role in single molecular electroluminescence induced by a scanning tunneling microscope (STM). But it has been difficult to clarify the complex experimental phenomena. By…

Mesoscale and Nanoscale Physics · Physics 2018-11-21 Lei-Lei Nian , Jing-Tao Lü

This paper reports on the excitation of surface plasmons on gold-coated nanofibre tips by side-illumination with a laser beam and the coupling of the surface plasmons to the optical fiber. The measurements show a strong dependence of the…

Optics · Physics 2015-06-16 D. Auwärter , C. Zimmermann , S. Slama