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Two full rotating gantry with different nozzles (Multipurpose nozzle with MLC, Scanning Dedicated nozzle) with conventional cyclotron system is installed and under commissioning for various proton treatment options at Samsung Medical Center…

The purpose of this study was to investigate the feasibility of extracting proton beams with two distinct energies within a single synchrotron cycle. The energy difference between the beams should be sufficient to use one beam as a range…

Accelerator Physics · Physics 2025-06-25 Alexander A. Pryanichnikov , Dmitry Shwartz , Jon Feldmand , Joao Seco , Maria Francesca Spadea

Proton therapy's full potential is limited by uncertainties that prevent optimal dose distribution. Monitoring techniques can reduce these uncertainties and enable adaptive treatment planning. Spatiotemporal Emission Reconstruction from…

Purpose: To demonstrate a proton imaging system based on well-established fast scintillator technology to achieve high performance with low cost and complexity, with the potential of a straightforward translation into clinical use. Methods:…

Particle therapy is an established method to treat deep-seated tumours using accelerator-produced ion beams. For treatment planning, the precise knowledge of the relative stopping power (RSP) within the patient is vital. Conversion errors…

We describe here a compact gantry system, when the lying patient is slowly moved in horizontal and vertical directions in accordance with rotation of transport channel around its axis so that the region, irradiated from different…

Accelerator Physics · Physics 2016-12-13 Alexander Mikhailichenko

The design, construction, and preliminary testing of a second generation proton CT scanner is presented. All current treatment planning systems at proton therapy centers use X-ray CT as the primary imaging modality for treatment planning to…

Treatment delivery is largely determined by capabilities of the beam delivery system (BDS), where faster delivery can have many potential benefits including improved dosimetric quality, utility, cost effectiveness, patient throughput and…

Medical Physics · Physics 2026-01-21 Jacinta Yap , Adam Steinberg , Hannah Norman , Konrad Nesteruk , Suzie Sheehy

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

Medical Physics · Physics 2015-05-14 Saverio Braccini

The recent demonstration that nanoparticles associated with various biological molecules and pharmacological agents can be administered systemically to humans, without toxicity from the particles, has opened a new era in the targeting of…

Medical Physics · Physics 2007-05-23 G. G. Kenning , R. Rodriguez , V. S. Zotev , A. Moslemi , S. Wilson , L. Hawel , C. Byus , J. S. Kovach

Proton radiography is used for advanced hydrotesting as a new type radiography technology due to its powerful penetration capability and high detection efficiency. A new proton radiography terminal will be developed to radiograph static…

Accelerator Physics · Physics 2015-01-28 Yan Yan , Li-Na Sheng , Zhi-Wu Huang , Jie Wang , Ze-En Yao , Jun-Run Wang , Zheng Wei , Jian-Cheng Yang , You-Jin Yuan

The major advantage of proton therapy over conventional radiotherapy is the dose deposition pattern, enabling precise coverage of the tumour volume while sparing nearby healthy tissues. However, accurate control of the proton beam range…

Medical Physics · Physics 2025-04-01 Magdalena Kołodziej

Using the China Spallation Neutron Source (CSNS) linac as the injector, a 500 MeV proton synchrotron is proposed for multidisciplinary application, such as biology, material and proton therapy. The synchrotron will deliver proton beam with…

Accelerator Physics · Physics 2016-09-21 Liang-Sheng Huang , Sheng Wang , Hong-Fei Ji

We discuss the principle possibility of stripping extraction in combination with reverse bends in isochronous separate sector cyclotrons (and/or FFAGs). If one uses reverse bends between the sectors (instead of drifts) and places stripper…

Accelerator Physics · Physics 2013-10-28 C. Baumgarten

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…

Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical…

We have demonstrated that GaN Schottky diodes can be used for high energy (64.8 MeV) proton detection. Such proton beams are used for tumor treatment, for which accurate and radiation resistant detectors are needed. Schottky diodes have…

Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

The purpose of this study is to determine whether organ sparing and target coverage can be simultaneously maintained for pencil beam scanning (PBS) proton therapy treatment of thoracic tumors in the presence of motion, stopping power…

We summarize recent results and ongoing activities in mathematical algorithms and computer science methods related to proton computed tomography (pCT) and intensity-modulated particle therapy (IMPT) treatment planning. Proton therapy…

Medical Physics · Physics 2021-08-24 Yair Censor , Keith E. Schubert , Reinhard W. Schulte