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There are several numerical models that describe real phenomena being used to solve complex problems. For example, an accurate numerical breast model can provide assistance to surgeons with visual information of the breast as a result of a…

Medical Physics · Physics 2020-03-17 Diogo Lopes , António Ramires Fernandes , Stéphane Clain

Parametric prediction error methods constitute a classical approach to the identification of linear dynamic systems with excellent large-sample properties. A more recent regularized approach, inspired by machine learning and Bayesian…

Systems and Control · Computer Science 2017-10-12 Johan Wågberg , Dave Zachariah , Thomas B. Schön

This work is concerned with the identifiability of metabolic parameters from multi-region measurement data in quantitative PET imaging. It shows that, for the frequently used two-tissue compartment model and under reasonable assumptions, it…

Optimization and Control · Mathematics 2023-05-29 Martin Holler , Erion Morina , Georg Schramm

A biopsy is the only diagnostic procedure for accurate histological confirmation of breast cancer. When sonographic placement is not feasible, a Magnetic Resonance Imaging(MRI)-guided biopsy is often preferred. The lack of real-time imaging…

Zero-dimensional cardiovascular models provide a computationally efficient framework for studying global hemodynamic behavior, yet the influence of model complexity on parameter sensitivity remains insufficiently understood. This work…

Medical Physics · Physics 2026-01-05 Pranav Kumar Sasikumar

We propose a geometric framework to assess sensitivity of Bayesian procedures to modeling assumptions based on the nonparametric Fisher-Rao metric. While the framework is general in spirit, the focus of this article is restricted to…

Methodology · Statistics 2014-04-28 Sebastian Kurtek , Karthik Bharath

Physics-inspired regularization is desired for intra-patient image registration since it can effectively capture the biomechanical characteristics of anatomical structures. However, a major challenge lies in the reliance on physical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Anna Reithmeir , Lina Felsner , Rickmer Braren , Julia A. Schnabel , Veronika A. Zimmer

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the…

Quantitative Methods · Quantitative Biology 2013-10-07 Marisa C. Eisenberg , Michael A. L. Hayashi

Mathematical modelling has become an established tool for studying the dynamics of biological systems. Current applications range from building models that reproduce quantitative data to identifying systems with predefined qualitative…

Molecular Networks · Quantitative Biology 2018-02-07 Carsten Conradi , Elisenda Feliu , Maya Mincheva , Carsten Wiuf

The identification of dynamic parameters in mechanical systems is important for improving model-based control as well as for performing realistic dynamic simulations. Generally, when identification techniques are applied only a subset of…

Robotics · Computer Science 2026-03-17 Miguel Díaz-Rodríguez , Vicente Mata , Angel Valera , Alvaro Page

We consider the reduction of parametric families of linear dynamical systems having an affine parameter dependence that differ from one another by a low-rank variation in the state matrix. Usual approaches for parametric model reduction…

Numerical Analysis · Mathematics 2019-12-25 Christopher Beattie , Serkan Gugercin , Zoran Tomljanovic

The explorations of models beyond the Standard Model (BSM) naturally involve scans over the unknown BSM parameters. On the other hand, high precision predictions require calculations at the loop-level and thus a renormalization of (some of)…

High Energy Physics - Phenomenology · Physics 2024-07-01 S. Heinemeyer , F. von der Pahlen

Our paper deals with inferring simulator-based statistical models given some observed data. A simulator-based model is a parametrized mechanism which specifies how data are generated. It is thus also referred to as generative model. We…

Machine Learning · Statistics 2016-01-01 Michael U. Gutmann , Jukka Corander

Physical models of biological systems can become difficult to interpret when they have a large number of parameters. But the models themselves actually depend on (i.e. are sensitive to) only a subset of those parameters. Rigorously…

Biological Physics · Physics 2018-11-27 Chieh-Ting Hsu , Gary J. Brouhard , Paul François

Conventional breast cancer imaging techniques are nowadays based on the use of ionising radiations or ultrasound waves for the inspection of breast areas. Nevertheless, these conventional techniques present some drawbacks related to patient…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Michele Ambrosanio , Stefano Franceschini , Vito Pascazio , Fabio Baselice

The paper focuses on the stiffness modeling of heavy industrial robots with gravity compensators. The main attention is paid to the identification of geometrical and elastostatic parameters and calibration accuracy. To reduce impact of the…

Robotics · Computer Science 2013-11-28 Alexandr Klimchik , Yier Wu , Claire Dumas , Stéphane Caro , Benoît Furet , Anatol Pashkevich

Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning. However, in…

Tissues and Organs · Quantitative Biology 2021-01-15 Laura Marx , Justyna A. Niestrawska , Matthias A. F. Gsell , Federica Caforio , Gernot Plank , Christoph M. Augustin

The creation of unique control methods for a hand prosthesis is still a problem that has to be addressed. The best choice of a human-machine interface (HMI) that should be used to enable natural control is still a challenge. Surface…

This monograph presents a geometric modeling method nonlinear dynamical systems from experimental data . basis method is a qualitative approach to the analysis of linear models and construction of the symmetry groups of attractors of…

Computational Engineering, Finance, and Science · Computer Science 2014-03-03 Evgeny Nikulchev

The efforts associated with parametrization of continuum-based models for crystal plasticity are a significant obstacle for the routine use of these models in materials science and engineering. While phenomenological constitutive…

Materials Science · Physics 2025-02-18 Nikhil Prabhu , Martin Diehl