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Liver allograft failure occurs in approximately 20% of liver transplant recipients within five years post-transplant, leading to mortality or the need for retransplantation. Providing an accurate and interpretable model for individualized…

Machine Learning · Computer Science 2024-08-13 Xiang Gao , Michael Cooper , Maryam Naghibzadeh , Amirhossein Azhie , Mamatha Bhat , Rahul G. Krishnan

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a rapid motor decline, leading to respiratory failure and subsequently to death. In this context, researchers have sought for models to automatically…

Machine Learning · Computer Science 2019-07-31 Telma Pereira , Sofia Pires , Marta Gromicho , Susana Pinto , Mamede de Carvalho , Sara C. Madeira

Random allocation models used in clinical trials aid researchers in determining which of a particular treatment provides the best results by reducing bias between groups. Often however, this determination leaves researchers battling ethical…

Applications · Statistics 2020-08-04 Albert. H. Lee , Edward L Boone , Roy T. Sabo , Erin Donahue

As pressure on the healthcare system increases, patients that require elective surgery experience longer access times to pre- and post-operative appointments and surgery. Hospitals can control their waiting lists by allocating timeslots to…

Optimization and Control · Mathematics 2024-10-15 Y. M. van der Vlugt , J. T. van Essen , R. F. M. Vromans , M. Carlier

The treatment allocation mechanism in a randomized clinical trial can be optimized by maximizing the nonparametric efficiency bound for a specific measure of treatment effect. Optimal treatment allocations which may or may not depend on…

Methodology · Statistics 2025-05-23 Wei Zhang , Zhiwei Zhang , Aiyi Liu

AI algorithms increasingly make decisions that impact entire groups of humans. Since humans tend to hold varying and even conflicting preferences, AI algorithms responsible for making decisions on behalf of such groups encounter the problem…

Artificial Intelligence · Computer Science 2020-06-18 Rachel Freedman

Reducing the shortage of organ donations to meet the demands of patients on the waiting list has being a major challenge in organ transplantation. Because of the shortage, organ matching decision is the most critical decision to assign the…

Machine Learning · Computer Science 2023-02-01 Parshin Shojaee , Xiaoyu Chen , Ran Jin

Oversubscribed treatments are often allocated using randomized waiting lists. Applicants are ranked randomly, and treatment offers are made following that ranking until all seats are filled. To estimate causal effects, researchers often…

Methodology · Statistics 2018-10-24 Clement de Chaisemartin , Luc Behaghel

Organ transplants can improve the life expectancy and quality of life for the recipient but carries the risk of serious post-operative complications, such as septic shock and organ rejection. The probability of a successful transplant…

Machine Learning · Computer Science 2016-11-15 Jinsung Yoon , Ahmed M. Alaa , Martin Cadeiras , Mihaela van der Schaar

We study the problem of allocating scarce societal resources of different types (e.g., permanent housing, deceased donor kidneys for transplantation, ventilators) to heterogeneous allocatees on a waitlist (e.g., people experiencing…

Optimization and Control · Mathematics 2025-08-13 Bill Tang , Çağıl Koçyiğit , Eric Rice , Phebe Vayanos

We consider the problem of individual-specific medication level recommendation (initiation, removal, increase, or decrease) for asthma sufferers. Asthma is one of the most common chronic diseases in both adults and children, affecting 8% of…

Applications · Statistics 2017-05-22 Curtis B Storlie , Megan E Branda , Michael R Gionfriddo , Nilay D Shah , Matthew A Rank

Using data from cardiovascular surgery patients with long and highly variable post-surgical lengths of stay (LOS), we develop a modeling framework to reduce recovery unit congestion. We estimate the LOS and its probability distribution…

Machine Learning · Computer Science 2022-11-30 Yuan Shi , Saied Mahdian , Jose Blanchet , Peter Glynn , Andrew Y. Shin , David Scheinker

Survival prediction with small sets of features is a highly relevant topic for decision-making in clinical practice. I describe a method for predicting survival of amyotrophic lateral sclerosis (ALS) patients that was developed as a…

Applications · Statistics 2016-12-05 Christoph Kurz

Liver transplantation continues to be the gold standard for treating patients with end-stage liver diseases. However, despite the huge success of liver transplantation in improving patient outcomes, long term graft survival continues to be…

Other Quantitative Biology · Quantitative Biology 2023-06-02 Raja Al-Bahou , Julia Bruner , Helen Moore , Ali Zarrinpar

In this paper, we conduct a study to optimize resource allocation for adaptive real-time and delay-tolerant applications in cellular systems. To represent the user applications via several devices and equipment, sigmoidal-like and logarithm…

Networking and Internet Architecture · Computer Science 2015-07-29 Zaid Kbah , Ahmed Abdelhadi

Oxygen is an essential life-saving medicine used in several indications at all levels of healthcare. During the COVID-19 pandemic, the demand for liquid medical oxygen (LMO) has increased significantly due to the occurrence of lung…

Systems and Control · Electrical Eng. & Systems 2023-05-10 Lejun Zhou , Lavanya Marla , Varun Gupta , Ankur Mani

Identifying optimal medical treatments to improve survival has long been a critical goal of pharmacoepidemiology. Traditionally, we use an average treatment effect measure to compare outcomes between treatment plans. However, new methods…

Platform trials are randomized clinical trials that allow simultaneous comparison of multiple interventions, usually against a common control. Arms to test experimental interventions may enter and leave the platform over time. This implies…

Methodology · Statistics 2024-04-12 Marta Bofill Roig , Ekkehard Glimm , Tobias Mielke , Martin Posch

In balanced allocations, the goal is to place $m$ balls into $n$ bins, so as to minimize the gap (difference of max to average load). The One-Choice process places each ball to a bin sampled independently and uniformly at random. The…

Discrete Mathematics · Computer Science 2023-04-24 Dimitrios Los , Thomas Sauerwald

Recent years have seen increasing efforts to forecast infectious disease burdens, with a primary goal being to help public health workers make informed policy decisions. However, there has only been limited discussion of how predominant…

Applications · Statistics 2024-03-06 Aaron Gerding , Nicholas G. Reich , Benjamin Rogers , Evan L. Ray