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Memory latency, bandwidth, capacity, and energy increasingly limit performance. In this paper, we reconsider proposed system architectures that consist of huge (many-terabyte to petabyte scale) memories shared among large numbers of CPUs.…

Hardware Architecture · Computer Science 2025-09-24 Samuel Dayo , Shuhan Liu , Peijing Li , Philip Levis , Subhasish Mitra , Thierry Tambe , David Tennenhouse , H. -S. Philip Wong

Large-language models (LLMs) are rapidly being applied to radiology, enabling automated image interpretation and report generation tasks. Their deployment in clinical practice requires both high diagnostic accuracy and low inference…

Tissues and Organs · Quantitative Biology 2025-11-11 Jyun-Ping Kao

Processing-in-memory (PIM) is a promising computing paradigm to tackle the "memory wall" challenge. However, PIM system-level benefits over traditional von Neumann architecture can be reduced when the memory array cannot fully store all the…

Hardware Architecture · Computer Science 2025-03-03 Peilin Chen , Xiaoxuan Yang

Data-intensive workloads and applications, such as machine learning (ML), are fundamentally limited by traditional computing systems based on the von-Neumann architecture. As data movement operations and energy consumption become key…

Hardware Architecture · Computer Science 2021-12-24 Mehdi Hassanpour , Marc Riera , Antonio González

The aim of this paper is to provide a comprehensive review of statistical challenges in neuroimaging data analysis from neuroimaging techniques to large-scale neuroimaging studies to statistical learning methods. We briefly review eight…

Applications · Statistics 2022-10-18 Hongtu Zhu , Tengfei Li , Bingxin Zhao

Generative AI has recently propelled the decoding of images from brain activity. How do these approaches scale with the amount and type of neural recordings? Here, we systematically compare image decoding from four types of non-invasive…

Image and Video Processing · Electrical Eng. & Systems 2025-01-29 Hubert Banville , Yohann Benchetrit , Stéphane d'Ascoli , Jérémy Rapin , Jean-Rémi King

Processing large numbers of key/value lookups is an integral part of modern server databases and other "Big Data" applications. Prior work has shown that hash table based key/value lookups can benefit significantly from using a dedicated…

Hardware Architecture · Computer Science 2021-05-17 Joshua Landgraf , Scott Lloyd , Maya Gokhale

Performance optimization is the art of continuous seeking a harmonious mapping between the application domain and hardware. Recent years have witnessed a surge of deep learning (DL) applications in industry. Conventional wisdom for…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-11-27 Guoping Long , Jun Yang , Wei Lin

Bioinformatics research is characterized by voluminous and incremental datasets and complex data analytics methods. The machine learning methods used in bioinformatics are iterative and parallel. These methods can be scaled to handle big…

Computational Engineering, Finance, and Science · Computer Science 2015-06-17 Hirak Kashyap , Hasin Afzal Ahmed , Nazrul Hoque , Swarup Roy , Dhruba Kumar Bhattacharyya

Large language models (LLMs) are central to modern natural language processing, delivering exceptional performance in various tasks. However, their substantial computational and memory requirements present challenges, especially for devices…

This volume is a collection of contributions from the 5th Workshop on Machine Learning and Interpretation in Neuroimaging (MLINI) at the Neural Information Processing Systems (NIPS 2015) conference. Modern multivariate statistical methods…

Machine Learning · Statistics 2016-05-17 I. Rish , L. Wehbe , G. Langs , M. Grosse-Wentrup , B. Murphy , G. Cecchi

High-performance computing systems are moving towards 2.5D and 3D memory hierarchies, based on High Bandwidth Memory (HBM) and Hybrid Memory Cube (HMC) to mitigate the main memory bottlenecks. This trend is also creating new opportunities…

Hardware Architecture · Computer Science 2017-09-26 Erfan Azarkhish , Davide Rossi , Igor Loi , Luca Benini

This paper presents a programmable in-memory-computing processor, demonstrated in a 65nm CMOS technology. For data-centric workloads, such as deep neural networks, data movement often dominates when implemented with today's computing…

Hardware Architecture · Computer Science 2020-09-17 Hongyang Jia , Yinqi Tang , Hossein Valavi , Jintao Zhang , Naveen Verma

Computing has a huge memory problem. The memory system, consisting of multiple technologies at different levels, is responsible for most of the energy consumption, performance bottlenecks, robustness problems, monetary cost, and hardware…

Hardware Architecture · Computer Science 2025-09-05 Onur Mutlu , Ataberk Olgun , Ismail Emir Yuksel

The conventional von Neumann architecture has been revealed as a major performance and energy bottleneck for rising data-intensive applications. %, due to the intensive data movements. The decade-old idea of leveraging in-memory processing…

Hardware Architecture · Computer Science 2019-06-18 Bing Li , Bonan Yan , Hai , Li

Most experimental sciences now rely on computing, and biological sciences are no exception. As datasets get bigger, so do the computing costs, making proper optimization of the codes used by scientists increasingly important. Many of the…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-07-21 Igor Sfiligoi , Daniel McDonald , Rob Knight

The widespread integration of embedded systems across various industries has facilitated seamless connectivity among devices and bolstered computational capabilities. Despite their extensive applications, embedded systems encounter…

Cryptography and Security · Computer Science 2024-04-16 Sreenitha Kasarapu , Sathwika Bavikadi , Sai Manoj Pudukotai Dinakarrao

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Background: We describe an informatics framework for researchers and clinical investigators to efficiently perform parameter sensitivity analysis and auto-tuning for algorithms that segment and classify image features in a large dataset of…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-12-13 George Teodoro , Tahsin Kurc , Luis F. R. Taveira , Alba C. M. A. Melo , Jun Kong , Joel Saltz

Bulk-bitwise processing-in-memory (PIM), an emerging computational paradigm utilizing memory arrays as computational units, has been shown to benefit database applications. This paper demonstrates how GROUP-BY and JOIN, database operations…

Hardware Architecture · Computer Science 2023-11-03 Ben Perach , Ronny Ronen , Shahar Kvatinsky