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Via a concomitant communication (the first part of my work), I have conclusively debunked the prevailing explanations for mitochondrial oxidative phosphorylation and established the need for a novel rationale to account for the reaction…

Subcellular Processes · Quantitative Biology 2018-12-21 Kelath Murali Manoj

BACKGROUND: The uncoupling protein (UCP) genes belong to the superfamily of electron transport carriers of the mitochondrial inner membrane. Members of the uncoupling protein family are involved in thermogenesis and determining the…

Populations and Evolution · Quantitative Biology 2008-12-16 Joseph Hughes , Francois Criscuolo

Several mechanisms by which an external electromagnetic field influences the temperature of a plasma are studied analytically and specialized to the system of an ultracold plasma (UCP) driven by a uniform radio frequency (RF) field. Heating…

Plasma Physics · Physics 2015-06-04 P. W. Smorenburg , L. P. J. Kamp , O. J. Luiten

The realization of microscopic heat engines has gained a surge of research interest in statistical physics, soft matter, and biological physics. A typical microscopic heat engine employs a colloidal particle trapped in a confining…

Mitochondria of brown adipocyte (BA) are the main intracellular sites for thermogenesis, which have been targeted for therapy to reduce obesity. However, there are long-standing critique and debates about the ability of raising cellular…

Subcellular Processes · Quantitative Biology 2018-04-16 Jian-Sheng Kang

We explain the physical basis of a model for small globular proteins with water interactions. The water is supposed to access the protein interior in an "all-or-none" manner during the unfolding of the protein chain. As a consequence of…

Condensed Matter · Physics 2009-10-31 Audun Bakk , Alex Hansen , Kim Sneppen

Thermogenesis is a physiological activity of releasing heat that originates from intracellular biochemical reactions. Recent experimental studies discovered that externally applied heat changes intracellular signaling locally, resulting in…

Biological Physics · Physics 2023-02-28 Ikuo Kurisaki , Madoka Suzuki

Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature,…

Biomolecules · Quantitative Biology 2009-11-13 Marek Cieplak , Joanna I. Sulkowska

The electron component of an ultracold neutral plasma (UCP) is modeled based on a scalable method using a self-consistently determined mean-field approximation. Representative sampling of discrete electrons within the UCP are used to…

Plasma Physics · Physics 2016-02-17 John Guthrie , Jacob Roberts

Using a structure-based coarse-grained model of proteins, we study the mechanism of unfolding of knotted proteins through heating. We find that the dominant mechanisms of unfolding depend on the temperature applied and are generally…

Biomolecules · Quantitative Biology 2017-01-23 Yani Zhao , Mateusz Chwastyk , Marek Cieplak

Mitochondrial oxidative phosphorylation (mOxPhos) makes ATP, the energy currency of life. Chemiosmosis, a proton centric mechanism, advocates that Complex V harnesses a transmembrane potential (TMP) for ATP synthesis. This perception of…

Subcellular Processes · Quantitative Biology 2018-12-21 Kelath Murali Manoj , Abhinav Parashar

One of the many ways cells transmit information within their volume is through steady spatial gradients of different proteins. However, the mechanism through which proteins without any sources or sinks form such single-cell gradients is not…

Biological Physics · Physics 2018-06-08 Saroj Kumar Nandi , Sam A. Safran

In this paper, we extend the unified kinetic particle (UGKP) method to the frequency-dependent radiative transfer equation with both absorption-emission and scattering processes. The extended UGKP method could not only capture the diffusion…

Computational Physics · Physics 2023-02-17 Yuan Hu , Chang Liu

Proteinoids -- thermal proteins -- are produced by heating amino acids to their melting point and initiation of polymerisation to produce polymeric chains. Proteinoids swell in aqueous solution into hollow microspheres. The proteinoid…

Emerging Technologies · Computer Science 2021-06-03 Andrew Adamatzky

We study theoretically the thermodynamics, over a broad temperature range (5 C to 125 C), related to hydrated water upon protein unfolding. The hydration effect is modeled as interacting dipoles in an external field, mimicking the influence…

Condensed Matter · Physics 2009-11-07 Audun Bakk , Johan S. Hoye , Alex Hansen

The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters e.g the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon…

Soft Condensed Matter · Physics 2010-10-19 Pragya Shukla

A production of heat by mitochondria is critical for maintaining body temperature, regulating metabolic rate and preventing oxidative damage to mitochondria and cells. Up to now mitochondrion heat production was characterized only by…

Biological Physics · Physics 2022-11-11 A. M. Romshin , A. A. Osypov , I. Yu. Popova , V. E. Zeeb , A. G. Sinogeykin , I. I. Vlasov

Thermophoresis is the migration of a particle due to a thermal gradient. Here, we theoretically uncover the quantum version of thermophoresis. As a proof of principle, we analytically find a thermophoretic force on a trapped quantum…

Quantum Physics · Physics 2026-02-20 Maurício Matos , Thiago Werlang , Daniel Valente

Membrane ultrafiltration (UF) is a pressure driven process allowing for the separation and enrichment of protein solutions and dispersions of nanosized microgel particles. The permeate flux and the near-membrane concentration-polarization…

Soft Condensed Matter · Physics 2015-05-19 Rafael Roa , Emiliy K. Zholkovskiy , Gerhard Nägele

This paper aims at the simulation of multiple scale physics in the system of radiation hydrodynamics. The system couples the fluid dynamic evolution equations with the radiative heat transfer. The coupled system is solved by the gas-kinetic…

Computational Physics · Physics 2019-09-12 Wenjun Sun , Song Jiang , Kun Xu , Guiyu Cao
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