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Distributed machine learning has been widely studied in the literature to scale up machine learning model training in the presence of an ever-increasing amount of data. We study distributed machine learning from another perspective, where…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-16 Yaochen Hu , Di Niu , Jianming Yang , Shengping Zhou

This work introduces ParAMS -- a versatile Python package that aims to make parameterization workflows in computational chemistry and physics more accessible, transparent and reproducible. We demonstrate how ParAMS facilitates the parameter…

Chemical Physics · Physics 2021-05-18 Leonid Komissarov , Robert Rüger , Matti Hellström , Toon Verstraelen

Meshfree particle methods, such as Smoothed Particle Hydrodynamics (SPH) and the Moving Particle Semi-Implicit (MPS) method, are widely used to simulate complex free-surface and multiphase flows. A key challenge in these methods is the…

Computational Physics · Physics 2025-10-22 Nariman Mehranfar , Ahmad Shakibaeinia

Foundation models (FMs) have transformed computational pathology by providing powerful, general-purpose feature extractors. However, adapting and benchmarking individual FMs for specific diagnostic tasks is often time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Peiran Quan , Zifan Gu , Zhuo Zhao , Qin Zhou , Donghan M. Yang , Ruichen Rong , Yang Xie , Guanghua Xiao

Force fields for molecular dynamics are usually developed manually, limiting their transferability and making systematic exploration of functional forms challenging. We developed a graph neural network that assigns all force field…

Biomolecules · Quantitative Biology 2026-03-18 Alexandre Blanco-González , Thea K Schulze , Evianne Rovers , Joe G Greener

The accuracy and efficiency of a coarse-grained (CG) force field are pivotal for high-precision molecular simulations of large systems with complex molecules. We present an automated mapping and optimization framework for molecular…

Computational Physics · Physics 2024-08-14 Zhixuan Zhong , Lifeng Xu , Jian Jiang

Machine learning has emerged as a powerful tool in various fields, including computer vision, natural language processing, and speech recognition. It can unravel hidden patterns within large data sets and reveal unparalleled insights,…

Machine Learning · Computer Science 2024-05-24 Abdeldjalil Latrach , Mohamed Lamine Malki , Misael Morales , Mohamed Mehana , Minou Rabiei

String kernels are attractive data analysis tools for analyzing string data. Among them, alignment kernels are known for their high prediction accuracies in string classifications when tested in combination with SVM in various applications.…

Machine Learning · Computer Science 2019-11-15 Yasuo Tabei , Yoshihiro Yamanishi , Rasmus Pagh

Polymer simulation with both accuracy and efficiency is a challenging task. Machine learning (ML) forcefields have been developed to achieve both the accuracy of ab initio methods and the efficiency of empirical force fields. However,…

Machine Learning · Computer Science 2023-09-04 Rui Feng , Huan Tran , Aubrey Toland , Binghong Chen , Qi Zhu , Rampi Ramprasad , Chao Zhang

Molecular dynamics (MD) simulation techniques are widely used for various natural science applications. Increasingly, machine learning (ML) force field (FF) models begin to replace ab-initio simulations by predicting forces directly from…

Computational Physics · Physics 2023-08-29 Xiang Fu , Zhenghao Wu , Wujie Wang , Tian Xie , Sinan Keten , Rafael Gomez-Bombarelli , Tommi Jaakkola

Constructing a classical potential suited to simulate a given atomic system is a remarkably difficult task. This chapter presents a framework under which this problem can be tackled, based on the Bayesian construction of nonparametric force…

Computational Physics · Physics 2020-07-01 Aldo Glielmo , Claudio Zeni , Ádám Fekete , Alessandro De Vita

Distance metric learning (DML) is an important task that has found applications in many domains. The high computational cost of DML arises from the large number of variables to be determined and the constraint that a distance metric has to…

Machine Learning · Computer Science 2013-04-05 Qi Qian , Rong Jin , Jinfeng Yi , Lijun Zhang , Shenghuo Zhu

Generating stable molecular conformations typically forces a tradeoff between the physical realism of energy-based relaxation and the sampling efficiency of data-driven generative models. While machine learning force fields (MLFFs) can…

Molecular dynamics (MD) simulations play a crucial role in resolving the underlying conformational dynamics of molecular systems. However, their capability to correctly reproduce and predict dynamics in agreement with experiments is limited…

Chemical Physics · Physics 2025-05-19 Ivan Gilardoni , Valerio Piomponi , Thorben Fröhlking , Giovanni Bussi

There is growing interest in using machine learning (ML) methods for structural metamodeling due to the substantial computational cost of traditional simulations. Purely data-driven strategies often face limitations in model robustness,…

Applied Physics · Physics 2024-04-30 R. Bailey Bond , Pu Ren , Jerome F. Hajjar , Hao Sun

Modeling stiff partial differential equations (PDEs) with sharp gradients remains a significant challenge for scientific machine learning. While Physics-Informed Neural Networks (PINNs) struggle with spectral bias and slow training times,…

Computational Engineering, Finance, and Science · Computer Science 2026-03-09 Akshay Govind Srinivasan , Balaji Srinivasan

``$\Delta$-machine learning" refers to a machine learning approach to bring a property such as a potential energy surface (PES) based on low-level (LL) density functional theory (DFT) energies and gradients to close to a coupled cluster…

Chemical Physics · Physics 2021-05-21 Apurba Nandi , Chen Qu , Paul Houston , Riccardo Conte , Joel M. Bowman

Potential Energy Surfaces (PESs) are an indispensable tool to investigate, characterise and understand chemical and biological systems in the gas and condensed phases. Advances in Machine Learning (ML) methodologies have led to the…

Chemical Physics · Physics 2025-11-04 Valerii Andreichev , Sena Aydin , Kai Töpfer , Markus Meuwly , Luis Itza Vazquez-Salazar

We provide a definition and explicit expressions for $n$-body Gaussian Process (GP) kernels which can learn any interatomic interaction occurring in a physical system, up to $n$-body contributions, for any value of $n$. The series is…

Computational Physics · Physics 2018-05-30 Aldo Glielmo , Claudio Zeni , Alessandro De Vita

Recent developments in many-body potential energy representation via deep learning have brought new hopes to addressing the accuracy-versus-efficiency dilemma in molecular simulations. Here we describe DeePMD-kit, a package written in…

Computational Physics · Physics 2018-05-23 Han Wang , Linfeng Zhang , Jiequn Han , Weinan E