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We develop a multiphysics-based model to predict the response of localized tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure combines hyperthermia (tumor heating) with standard radiotherapy to improve efficacy of…

Tissues and Organs · Quantitative Biology 2019-07-05 Japan K. Patel , Richard Vasques , Barry D. Ganapol

Computational pathology is part of precision oncology medicine. The integration of high-throughput data including genomics, transcriptomics, proteomics, metabolomics, pathomics, and radiomics into clinical practice improves cancer treatment…

Image and Video Processing · Electrical Eng. & Systems 2022-06-07 Liangrui Pan , Zhichao Feng , Shaoliang Peng

Stereotactic body radiation therapy (SBRT) refers to focusing high-energy rays in three-dimensional space on the tumor lesion area, reducing the dose received by surrounding normal tissues, which can effectively improve the local control…

Medical Physics · Physics 2024-02-27 Yanqi Zong , Zhengrong Cui , Luqi Lin , Sihao Wang , Yizhi Chen

Radiation therapy is an important tool in the treatment of breast cancer and can play a crucial role in improving patient outcomes. For breast cancer, if the technique has been for a long time the use of 3DCRT, clinicians have seen the…

This paper presents a new technique for the virtual reality (VR) visu-alization of complex volume images obtained from computer tomography (CT) and Magnetic Resonance Imaging (MRI) by combining three-dimensional (3D) mesh processing and…

Multimedia · Computer Science 2023-05-02 Iva Vasic , Roberto Pierdicca , Emanuele Frontoni , Bata Vasic

A dynamical system model for tumor -- immune system interaction together with a method to mimic radiation therapy are proposed. A large population of virtual patients is simulated following an ideal radiation treatment. A characteristic…

Populations and Evolution · Quantitative Biology 2007-06-28 O. Sotolongo-Grau , D. Rodriguez-Perez , J. A. Santos-Miranda , O. Sotolongo-Costa , J. C. Antoranz

Purpose. Radiation therapy is a local treatment aimed at cells in and around a tumor. The goal of this study is to develop an algorithmic solution for predicting the position of a target in 3D in real time, aiming for the short fixed…

Artificial Intelligence · Computer Science 2015-08-05 Tomas Krilavicius , Indre Zliobaite , Henrikas Simonavicius , Laimonas Jarusevicius

It has long been known that radiation biology plays an important role and it is necessary for radiotherapy treatments. The radiation effects on normal and malignant tissues after exposure range from a femtosecond to months and years…

Medical Physics · Physics 2017-04-24 Cyril Voyant , Daniel Julian

In this work, we focus on the analytical and numerical study of a mathematical model for brain tumors with radiotherapy influence. Under certain assumptions on the given data in the model, we prove existence and uniqueness of a weak…

Analysis of PDEs · Mathematics 2024-09-27 Marina Chugunova , Hangjie Ji , Roman Taranets , Nataliya Vasylyeva

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

Medical Physics · Physics 2015-05-14 Saverio Braccini

We present for the first time a general 6DoF trajectory planning method that can be used in real-time image guided radiation therapy procedures for robotic stabilization of dynamically moving tumor targets. As the radiation beam is always…

Medical Physics · Physics 2018-08-14 Rodney D. Wiersma , Xinmin Liu

Augmented Reality (AR) systems add visual information to the world by using advanced display techniques. The advances in miniaturization and reduced costs make some of these systems feasible for applications in a wide set of fields. We…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-11-30 Felix G. Hamza-Lup , Anand P. Santhanam , Celina Imielinska , Sanford Meeks , Jannick P. Rolland

Many important chemical and biochemical processes in the condensed phase are notoriously difficult to simulate numerically. Often this difficulty arises from the complexity of simulating dynamics resulting from coupling to structured,…

Augmented Reality (AR) systems describe the class of systems that use computers to overlay virtual information on the real world. AR environments allow the development of promising tools in several application domains. In medical training…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-12-03 Felix G. Hamza-Lup , Jannick P. Rolland , Charles Hughes

Intraoperative observation of tissue internal structure is often difficult. Hence, real-time soft tissue deformation is essential for the localization of tumor and other internal structures. We propose a method to simulate the internal…

Computational Geometry · Computer Science 2019-07-26 Haoyin Zhou , Eva Gombos , Mehra Golshan , Jayender Jagadeesan

Laser acceleration promises innovation in particle beam therapy of cancer where an ultra-compact accelerator system for cancer beam therapy can become affordable to a broad range of patients. This is not feasible without the introduction of…

Radiation therapy (RT) is a medical treatment to kill cancer cells or shrink tumors. To manually schedule patients for RT is a time-consuming and challenging task. By the use of optimization, patient schedules for RT can be created…

Optimization and Control · Mathematics 2023-05-04 Sara Frimodig , Per Enqvist , Mats Carlsson , Carole Mercier

A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid…

Tissues and Organs · Quantitative Biology 2020-07-01 Hang Xie , Yang Jiao , Qihui Fan , Miaomiao Hai , Jiaen Yang , Zhijian Hu , Yue Yang , Jianwei Shuai , Guo Chen , Ruchuan Liu , Liyu Liu

Simulation especially real-time simulation have been widely used for the design and testing of real-time systems. The advancement of simulation tools has largely attributed to the evolution of computing technologies. With the reduced cost…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-07 Xi Zheng

The aim of this chapter is to provide a brief introduction into the basics of a top-down multilevel tumor dynamics modeling method primarily based on discrete entity consideration and manipulation. The method is clinically oriented, one of…

Medical Physics · Physics 2010-09-14 Georgios Stamatakos