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Whole slide image (WSI) classification often relies on deep weakly supervised multiple instance learning (MIL) methods to handle gigapixel resolution images and slide-level labels. Yet the decent performance of deep learning comes from…

Computer Vision and Pattern Recognition · Computer Science 2022-07-06 Jiawei Yang , Hanbo Chen , Yu Zhao , Fan Yang , Yao Zhang , Lei He , Jianhua Yao

Multiple Instance Learning (MIL) represents the predominant framework in Whole Slide Image (WSI) classification, covering aspects such as sub-typing, diagnosis, and beyond. Current MIL models predominantly rely on instance-level features…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Heng Fang , Sheng Huang , Wenhao Tang , Luwen Huangfu , Bo Liu

Various multi-instance learning (MIL) based approaches have been developed and successfully applied to whole-slide pathological images (WSI). Existing MIL methods emphasize the importance of feature aggregators, but largely neglect the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Yicheng Song , Tiancheng Lin , Die Peng , Su Yang , Yi Xu

As a widely used weakly supervised learning scheme, modern multiple instance learning (MIL) models achieve competitive performance at the bag level. However, instance-level prediction, which is essential for many important applications,…

Machine Learning · Computer Science 2022-06-14 Hitesh Sapkota , Qi Yu

Class-incremental learning (CIL) has been widely studied under the setting of starting from a small number of classes (base classes). Instead, we explore an understudied real-world setting of CIL that starts with a strong model pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2022-09-13 Tz-Ying Wu , Gurumurthy Swaminathan , Zhizhong Li , Avinash Ravichandran , Nuno Vasconcelos , Rahul Bhotika , Stefano Soatto

Mixed-integer linear programming (MILP) is a powerful tool for addressing a wide range of real-world problems, but it lacks a clear structure for comparing instances. A reliable similarity metric could establish meaningful relationships…

Machine Learning · Computer Science 2025-07-16 Gwen Maudet , Grégoire Danoy

Multiple Instance Learning (MIL) for whole slide image (WSI) analysis in computational pathology often neglects instance-level learning as supervision is typically provided only at the bag level, hindering the integrated consideration of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shuyang Wu , Yifu Qiu , Ines P. Nearchou , Sandrine Prost , Jonathan A. Fallowfield , Hideki Ueno , Hitoshi Tsuda , David J. Harrison , Hakan Bilen , Timothy J. Kendall

Multi-Instance Learning (MIL) is pivotal for analyzing complex, weakly labeled datasets, such as whole-slide images (WSIs) in computational pathology, where bags comprise unordered collections of instances with sparse diagnostic relevance.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-16 Yuedi Zhang , Zhixiang Xia , Guosheng Yin , Bin Liu

Transfer learning from large-scale pre-trained models has become essential for many computer vision tasks. Recent studies have shown that datasets like ImageNet are weakly labeled since images with multiple object classes present are…

Computer Vision and Pattern Recognition · Computer Science 2021-11-25 Sai Rajeswar , Pau Rodriguez , Soumye Singhal , David Vazquez , Aaron Courville

Multi-instance learning is a type of weakly supervised learning. It deals with tasks where the data is a set of bags and each bag is a set of instances. Only the bag labels are observed whereas the labels for the instances are unknown. An…

Machine Learning · Computer Science 2021-05-05 Weijia Zhang

Weakly-supervised action localization requires training a model to localize the action segments in the video given only video level action label. It can be solved under the Multiple Instance Learning (MIL) framework, where a bag (video)…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Zhekun Luo , Devin Guillory , Baifeng Shi , Wei Ke , Fang Wan , Trevor Darrell , Huijuan Xu

Given the special situation of modeling gigapixel images, multiple instance learning (MIL) has become one of the most important frameworks for Whole Slide Image (WSI) classification. In current practice, most MIL networks often face two…

Computer Vision and Pattern Recognition · Computer Science 2024-01-11 Pei Liu , Luping Ji , Xinyu Zhang , Feng Ye

Multi-instance learning (MIL) is a widely-applied technique in practical applications that involve complex data structures. MIL can be broadly categorized into two types: traditional methods and those based on deep learning. These…

Artificial Intelligence · Computer Science 2023-04-25 Yu-Xuan Zhang , Zhengchun Zhou , Xingxing He , Avik Ranjan Adhikary , Bapi Dutta

In this paper, we propose the MIML (Multi-Instance Multi-Label learning) framework where an example is described by multiple instances and associated with multiple class labels. Compared to traditional learning frameworks, the MIML…

Machine Learning · Computer Science 2011-10-28 Zhi-Hua Zhou , Min-Ling Zhang , Sheng-Jun Huang , Yu-Feng Li

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

The detection of induced pluripotent stem cell (iPSC) colonies often needs the precise extraction of the colony features. However, existing computerized systems relied on segmentation of contours by preprocessing for classifying the colony…

Image and Video Processing · Electrical Eng. & Systems 2022-03-10 Novanto Yudistira , Muthu Subash Kavitha , Jeny Rajan , Takio Kurita

In this paper, we propose an extension to an existing algorithm (instance-MIR) which tackles the multiple instance regression (MIR) problem, also known as distribution regression. The MIR setting arises when the data is a collection of…

Machine Learning · Statistics 2019-08-20 Thomas Uriot

We propose a Multi-Instance-Learning (MIL) approach for weakly-supervised learning problems, where a training set is formed by bags (sets of feature vectors or instances) and only labels at bag-level are provided. Specifically, we consider…

Computer Vision and Pattern Recognition · Computer Science 2018-07-04 Adria Ruiz , Ognjen Rudovic , Xavier Binefa , Maja Pantic

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

Classification and localization are two pillars of visual object detectors. However, in CNN-based detectors, these two modules are usually optimized under a fixed set of candidate (or anchor) bounding boxes. This configuration significantly…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Wei Ke , Tianliang Zhang , Zeyi Huang , Qixiang Ye , Jianzhuang Liu , Dong Huang
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