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The first experimental data from single-particle scattering experiments from free electron lasers (FELs) are now becoming available. The first such experiments are being performed on relatively large objects such as viruses, which produce…

Biomolecules · Quantitative Biology 2015-05-28 Dilano Saldin , Hin-Cheuck Poon , Peter Schwander , Miraj Uddin , Marius Schmidt

Revealing the structure of complex biological macromolecules, such as proteins, is an essential step for understanding the chemical mechanisms that determine the diversity of their functions. Synchrotron based x-ray crystallography and…

We proposed a novel approach to coherent imaging of dynamic samples. The inter-frame similarity of the sample's local structures is found to be a powerful constraint in phasing a sequence of diffraction patterns. We devised a new image…

Optics · Physics 2024-07-11 Pengju Sheng , Fucai Zhang

Accelerator-based X-ray free-electron lasers (XFELs) are the latest addition to the revolutionary tools of discovery for the 21st century. The two major components of an XFEL are an accelerator-produced electron beam and a magnetic…

The Single Particles, Clusters and Biomolecules (SPB) instrument at the European XFEL is located behind the SASE1 undulator, and aims to support imaging and structure determination of biological specimen between about 0.1 micrometer and 1…

Spontaneous parametric down-conversion is a vital method for generating correlated photon pairs in the visible and near-infrared spectral regions; however, its extension to X-ray frequencies has faced substantial barriers. Here, we present…

We present results of a coherent x-ray diffractive imaging experiment performed on a single colloidal crystal grain. The full three-dimensional (3D) reciprocal space map measured by an azimuthal rotational scan contained several orders of…

To obtain spatial information about an arbitrary object in x-ray structure analysis, the standard method is to measure the intensity in the far field, i.e., the first-order photon correlation function of the coherently scattered x-ray…

Quantum Physics · Physics 2023-12-20 M. Bojer , J. Eckert , S. Karl , S. Richter , J. von Zanthier

X-ray free-electron lasers (FEL) deliver ultrabright X-ray pulses, but not the sequences of phase-coherent pulses required for time-domain interferometry and control of quantum states. For conventional split-and-delay schemes to produce…

Accelerator Physics · Physics 2022-02-11 S. Reiche , G. Knopp , B. Pedrini , E. Prat , G. Aeppli , S. Gerber

To take advantage of high-resolution optics sensitive to a broad energy range, future X-ray imaging instruments will require thick detectors with small pixels. This pixel aspect ratio affects spectral response in the soft X-ray band, vital…

We present calculations of the time lags and the coherence function of X-ray photons for a novel model of radiation emission from accretion powered, high-energy sources. Our model involves only Comptonization of soft photons injected near…

Astrophysics · Physics 2009-10-30 Xin-Min Hua , Demosthenes Kazanas , Lev Titarchuk

Sub-angstrom spatial resolution of electron density coupled with sub-femtosecond temporal resolution is required to directly observe the dynamics of the electronic structure of a molecule after photoinitiation or some other ultrafast…

The core theme of X-ray crystallography is reconstructing the electron density distribution of crystals under the constraints of observed diffraction data. Nevertheless, the reconstruction of electron density distribution by straightforward…

Materials Science · Physics 2015-07-14 Hui Li , Meng He , Ze Zhang

We present a novel diffractive imaging method that harnesses a low-resolution real-space image to guide the phase retrieval. A computational algorithm is developed to utilize such prior knowledge as a real-space constraint in the iterative…

Optics · Physics 2020-10-27 Po-Nan Li , Soichi Wakatsuki , Piero A. Pianetta , Yijin Liu

Atomic-resolution imaging with scanning transmission electron microscopy is a powerful tool for characterizing the nanoscale structure of materials, in particular features such as defects, local strains, and symmetry-breaking distortions.…

Condensed phase systems often exhibit a mixture of deterministic and stochastic dynamics at the nanoscale which are essential to understanding their function, but can be challenging to study directly using conventional imaging methods.…

Optics · Physics 2025-01-17 Arnab Sarkar , Allan S. Johnson

Ptychographic imaging at synchrotron and XFEL sources requires dense overlapping scans, limiting throughput and increasing dose. Extending coherent diffractive imaging to overlap-free operation on extended samples remains an open problem.…

Optics · Physics 2026-05-01 Oliver Hoidn , Albert Vong , Aashwin Mishra , Steven Henke , Matthew Seaberg