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Alzheimer's disease (AD) diagnosis requires integrating neuroimaging with heterogeneous clinical evidence and reasoning under established criteria, yet most multimodal models remain opaque and weakly guideline-aligned. We present…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Qiuhui Chen , Yushan Deng , Xuancheng Yao , Yi Hong

To achieve effective and efficient detection of Alzheimer's disease (AD), many machine learning methods have been introduced into this realm. However, the general case of limited training samples, as well as different feature…

Machine Learning · Computer Science 2013-10-04 Fayao Liu , Luping Zhou , Chunhua Shen , Jianping Yin

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders worldwide. As it progresses, it leads to the deterioration of cognitive functions. Since AD is irreversible, early diagnosis is crucial for managing its…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mahdieh Behjat Khatooni , Mohsen Soryani

Deep Convolutional Neural Networks (CNNs) are becoming prominent models for semi-automated diagnosis of Alzheimer's Disease (AD) using brain Magnetic Resonance Imaging (MRI). Although being highly accurate, deep CNN models lack transparency…

Machine Learning · Computer Science 2020-04-28 Eduardo Nigri , Nivio Ziviani , Fabio Cappabianco , Augusto Antunes , Adriano Veloso

In recent days, Convolutional Neural Networks (CNN) have demonstrated impressive performance in medical image analysis. However, there is a lack of clear understanding of why and how the Convolutional Neural Network performs so well for…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Jyoti Islam , Yanqing Zhang

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit…

Machine Learning · Computer Science 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

Alzheimer's disease (AD) is the most common form of dementia, which causes problems with memory, thinking and behavior. Growing evidence has shown that the brain connectivity network experiences alterations for such a complex disease.…

Methodology · Statistics 2020-05-29 Chen Hao , Guo Ying , He Yong , Ji Jiadong , Liu Lei , Shi Yufeng , Wang Yikai , Yu Long , Zhang Xinsheng

In the recent years there have been a number of studies that applied deep learning algorithms to neuroimaging data. Pipelines used in those studies mostly require multiple processing steps for feature extraction, although modern…

Computer Vision and Pattern Recognition · Computer Science 2017-01-25 Sergey Korolev , Amir Safiullin , Mikhail Belyaev , Yulia Dodonova

Discriminative analysis in neuroimaging by means of deep/machine learning techniques is usually tested with validation techniques, whereas the associated statistical significance remains largely under-developed due to their computational…

Recent evidence has shown that structural magnetic resonance imaging (MRI) is an effective tool for Alzheimer's disease (AD) prediction and diagnosis. While traditional MRI-based diagnosis uses images acquired at a single time point, a…

Applications · Statistics 2021-11-02 Xiaowu Dai

Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-16 Xin Zhang , Liangxiu Han , Wenyong Zhu , Liang Sun , Daoqiang Zhang

Multimodal data analysis can lead to more accurate diagnoses of brain disorders due to the complementary information that each modality adds. However, a major challenge of using multimodal datasets in the neuroimaging field is incomplete…

Image and Video Processing · Electrical Eng. & Systems 2025-08-14 Reihaneh Hassanzadeh , Anees Abrol , Hamid Reza Hassanzadeh , Vince D. Calhoun

In the complex realm of cognitive disorders, Alzheimer's disease (AD) and vascular dementia (VaD) are the two most prevalent dementia types, presenting entangled symptoms yet requiring distinct treatment approaches. The crux of effective…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Salma Hassan , Dawlat Akaila , Maryam Arjemandi , Vijay Papineni , Mohammad Yaqub

Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…

Machine Learning · Computer Science 2026-03-23 Alireza Moayedikia , Sara Fin

Recent studies suggest that combined analysis of Magnetic resonance imaging~(MRI) that measures brain atrophy and positron emission tomography~(PET) that quantifies hypo-metabolism provides improved accuracy in diagnosing Alzheimer's…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Apoorva Sikka , Skand Vishwanath Peri , Deepti. R. Bathula

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with increasing prevalence among the aging population, necessitating early and accurate diagnosis for effective disease management. In this study, we present a novel…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Romoke Grace Akindele , Samuel Adebayo , Paul Shekonya Kanda , Ming Yu

In recent years, the number of papers on Alzheimer's disease classification has increased dramatically, generating interesting methodological ideas on the use machine learning and feature extraction methods. However, practical impact is…

Being the most commonly known neurodegeneration, Alzheimer's Disease (AD) is annually diagnosed in millions of patients. The present medical scenario still finds the exact diagnosis and classification of AD through neuroimaging data as a…

Image and Video Processing · Electrical Eng. & Systems 2025-03-19 Shravan Venkatraman , Pandiyaraju V , Abeshek A , Pavan Kumar S , Aravintakshan S A

Alzheimer's Disease (AD) detection employs machine learning classification models to distinguish between individuals with AD and those without. Different from conventional classification tasks, we identify within-class variation as a…

Audio and Speech Processing · Electrical Eng. & Systems 2025-09-29 Jiawen Kang , Dongrui Han , Lingwei Meng , Jingyan Zhou , Jinchao Li , Xixin Wu , Helen Meng

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that predominantly affects the elderly population and currently has no cure. Magnetic Resonance Imaging (MRI), as a non-invasive imaging technique, is essential for the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-24 Xinyue Yang , Meiliang Liu , Yunfang Xu , Xiaoxiao Yang , Zhengye Si , Zijin Li , Zhiwen Zhao