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Structural MRI and PET imaging play an important role in the diagnosis of Alzheimer's disease (AD), showing the morphological changes and glucose metabolism changes in the brain respectively. The manifestations in the brain image of some…

Image and Video Processing · Electrical Eng. & Systems 2023-08-11 Yanteng Zhang , Qizhi Teng , Xiaohai He , Tong Niu , Lipei Zhang , Yan Liu , Chao Ren

Attribution methods are an easy to use tool for investigating and validating machine learning models. Multiple methods have been suggested in the literature and it is not yet clear which method is most suitable for a given task. In this…

Image and Video Processing · Electrical Eng. & Systems 2019-09-20 Fabian Eitel , Kerstin Ritter

Alzheimer's disease (AD) is a degenerative brain disease impairing a person's ability to perform day to day activities. The clinical manifestations of Alzheimer's disease are characterized by heterogeneity in age, disease span, progression…

Machine Learning · Computer Science 2018-12-07 Vipul Satone , Rachneet Kaur , Faraz Faghri , Mike A Nalls , Andrew B Singleton , Roy H Campbell

We propose to apply a 2D CNN architecture to 3D MRI image Alzheimer's disease classification. Training a 3D convolutional neural network (CNN) is time-consuming and computationally expensive. We make use of approximate rank pooling to…

Computer Vision and Pattern Recognition · Computer Science 2021-01-14 Xin Xing , Gongbo Liang , Hunter Blanton , Muhammad Usman Rafique , Chris Wang , Ai-Ling Lin , Nathan Jacobs

It is of great significance to apply deep learning for the early diagnosis of Alzheimer's Disease (AD). In this work, a novel tensorizing GAN with high-order pooling is proposed to assess Mild Cognitive Impairment (MCI) and AD. By…

Machine Learning · Computer Science 2020-08-04 Wen Yu , Baiying Lei , Michael K. Ng , Albert C. Cheung , Yanyan Shen , Shuqiang Wang

Early detection is crucial to prevent the progression of Alzheimer's disease (AD). Thus, specialists can begin preventive treatment as soon as possible. They demand fast and precise assessment in the diagnosis of AD in the earliest and…

Machine Learning · Computer Science 2021-05-19 Alejandro Puente-Castro , Enrique Fernandez-Blanco , Alejandro Pazos , Cristian R. Munteanu

Cross-modal fusion of different types of neuroimaging data has shown great promise for predicting the progression of Alzheimer's Disease(AD). However, most existing methods applied in neuroimaging can not efficiently fuse the functional and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-15 Junren Pan , Shuqiang Wang

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive…

Nowadays, a lot of scientific efforts are concentrated on the diagnosis of Alzheimer's Disease (AD) applying deep learning methods to neuroimaging data. Even for 2017, there were published more than a hundred papers dedicated to AD…

Machine Learning · Computer Science 2018-07-31 Yaroslav Shmulev , Mikhail Belyaev

Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical…

Sound · Computer Science 2021-03-04 Junghyun Koo , Jie Hwan Lee , Jaewoo Pyo , Yujin Jo , Kyogu Lee

For effective treatment of Alzheimer disease (AD), it is important to identify subjects who are most likely to exhibit rapid cognitive decline. Herein, we developed a novel framework based on a deep convolutional neural network which can…

Computer Vision and Pattern Recognition · Computer Science 2017-04-21 Hongyoon Choi , Kyong Hwan Jin

Alzheimer's disease is an untreatable, progressive brain disorder that slowly robs people of their memory, thinking abilities, and ultimately their capacity to complete even the most basic tasks. Among older adults, it is the most frequent…

Image and Video Processing · Electrical Eng. & Systems 2025-02-11 Nasser A Alsadhan

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Visualizing and interpreting convolutional neural networks (CNNs) is an important task to increase trust in automatic medical decision making systems. In this study, we train a 3D CNN to detect Alzheimer's disease based on structural MRI…

Computer Vision and Pattern Recognition · Computer Science 2018-12-07 Johannes Rieke , Fabian Eitel , Martin Weygandt , John-Dylan Haynes , Kerstin Ritter

Nowadays, due to tremendous improvements in high performance computing, it has become easier to train Neural Networks. We intend to take advantage of this situation and apply this technology in solving real world problems. There was a need…

Computer Vision and Pattern Recognition · Computer Science 2019-10-15 Gururaj Awate , Sunil Bangare , G Pradeepini , S Patil

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

Artificial Intelligence · Computer Science 2021-08-11 Changhyun Park , Heung-Il Suk

Alzheimer's disease (AD) is associated with local (e.g. brain tissue atrophy) and global brain changes (loss of cerebral connectivity), which can be detected by high-resolution structural magnetic resonance imaging. Conventionally, these…

Machine Learning · Computer Science 2021-05-11 Sarah C. Brüningk , Felix Hensel , Catherine R. Jutzeler , Bastian Rieck

Accurate and efficient classification of Alzheimer's disease (AD) severity from brain magnetic resonance imaging (MRI) remains a critical challenge, particularly when limited data and model interpretability are of concern. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Faisal Ahmed

Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the…

Machine Learning · Computer Science 2022-04-29 Houliang Zhou , Lifang He , Yu Zhang , Li Shen , Brian Chen

Using multimodal neuroimaging data to characterize brain network is currently an advanced technique for Alzheimer's disease(AD) Analysis. Over recent years the neuroimaging community has made tremendous progress in the study of…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Junren Pan , Baiying Lei , Yanyan Shen , Yong Liu , Zhiguang Feng , Shuqiang Wang